Protective Role of Mangiferin against Benzo(a)pyrene Induced Lung Carcinogenesis in Experimental Animals

Abstract

In recent years, considerable emphasis has been focused on identifying new chemopreventive agents which could be useful for the human population. In the present study, we examined the protective role of mangiferin during experimental lung carcinogenesis with reference to its effect on DNA-damage and the detoxification enzyme system. The activities of detoxifying enzymes such as glutathione transferase (GST), quinone reductase (QR) and uridin 5-diphosphate-glucuronosyl transferase (UDP-GT) were found to be decreased while the lipid peroxidation level was increased in the lung cancer bearing animals. Supplementation of mangiferin (100 mg/kg b.wt) enhanced the detoxification enzymes and reduced DNA damage as determined by single cell electrophoresis. Furthermore, the DNA-protein cross links which was found to be high in lung cancer bearing animals was also modulated upon supplementation with mangiferin. Our present results explain the unique association between the anti-oxidant effect of mangiferin and ultimately the capability of mangiferin to prevent cancer.

Chemopreventive effects of caraway powder and oils to suppress 1, 2- dimethylhydrazine-induced colon carcinogenesis

“…Sonuç: Bu çalışmanın sonucunda, kimyon tozu ve yağı ile elde edilen kolona ait kemopreventif etkilerden birinin DMH metabolizmasında ki düzenleyici etki veya etkilerinin kolon β-katenin protein ve mRNA düzeyinde azalmaya neden olarak oluştuğu görülmüştür. natural compounds such as mangiferin, furan-2-yl-3-pyridin-2-yl-propenone (FPP-3), curcumin should also be useful [25][26][27][28].…”

“…Sonuç: Bu çalışmanın sonucunda, kimyon tozu ve yağı ile elde edilen kolona ait kemopreventif etkilerden birinin DMH metabolizmasında ki düzenleyici etki veya etkilerinin kolon β-katenin protein ve mRNA düzeyinde azalmaya neden olarak oluştuğu görülmüştür. natural compounds such as mangiferin, furan-2-yl-3-pyridin-2-yl-propenone (FPP-3), curcumin should also be useful [25][26][27][28].Caraway [Carum carvi L., (Umbelliferae)] known as "meridian fennel" or "Persian cumin" has been commonly used like a whole seed in phytomedicine as antibacterial, antiproliferative and laxative agent [29][30][31]. The caraway seeds contain many ingredients such as essential oils and aqueous extract that likely work together to produce the desired medicinal effect.…”

“…natural compounds such as mangiferin, furan-2-yl-3-pyridin-2-yl-propenone (FPP-3), curcumin should also be useful [25][26][27][28].…”

Mangiferin activates the Nrf2-ARE pathway and reduces etoposide-induced DNA damage in human umbilical cord mononuclear blood cells

“…Mango juice and juice extracts can inhibit chemical-induced neoplastic transformation of mammalian cell lines, suggesting their chemopreventive activities (Percival et al, 2006). Moreover, mangiferin inhibited chemical carcinogen-induced lung or colon cancer in experimental animals, indicating that it is a naturally occurring chemopreventive agent (Rajendran et al, 2008;Yoshimi et al, 2001). However, it is unclear whether mangiferin has an inhibitory effect on leukemia and its related molecular mechanisms.…”

“…However, it is unclear whether mangiferin has an inhibitory effect on leukemia and its related molecular mechanisms. Although it has been demonstrated that mangiferin treatment can upregulate the expression of detoxification enzymes and reduce DNA damage in a benzo(a)pyrene-induced lung carcinogenesis animal model (Rajendran et al, 2008), it is still unclear whether the inhibitory effect of mangiferin treatment on carcinogenesis is achieved by Nrf-ARE signaling and detoxification enzymes.…”