Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

Abstract

The present study was conducted to investigate the protective role of Omega-3 polyunsaturated fatty acids against lead acetate-induced toxicity in liver and kidney of female rats. Animals were divided into four equal groups; group 1 served as control while groups 2 and 3 were treated orally with Omega-3 fatty acids at doses of 125 and 260 mg/kg body weight, respectively, for 10 days. These groups were also injected with lead acetate (25 mg/kg body weight) during the last 5 days. Group 4 was treated only with lead acetate for 5 days and served as positive control group. Lead acetate increased oxidative stress through an elevation in MDA associated with depletion in antioxidant enzymes activities in the tissues. Moreover, the elevation of serum enzymes activities (ALT, AST, ALP, and LDH) and the levels of urea and creatinine were estimated but total proteins were decreased. Also, lead acetate-treatment induced hyperlipidemia via increasing of lipid profiles associated with decline in HDL-c level. Significant changes of Hb, PCV, RBCs, PLT, and WBCs in group 4 were recorded. The biochemical alterations of lead acetate were confirmed by histopathological changes and DNA damage. The administration of Omega-3 provided significant protection against lead acetate toxicity.

The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

“…In the study done by Takase et al in 2011 it was indicated that EPA blocked the development of tubulointersititial damage in models with Thy-1 nephritis and had inhibitory effects on inflammatory molecules by regulating IKBa in cultured renal cells [24]. The study that Abdou et al conductd in 2014 declared that omega-3 fatty acids prevented renal toxicity induced by lead in rats [25]. Peake et al in 2011 concluded that consuming fish oils prevented the oxidative stress, fibrosis and inflammation related to kidney damage in rats [26].…”

Comparative Effect of Silymarin and D-Penicillamine on Lead Induced Hemotoxicity and Oxidative Stress in Rat

“…All groups were subjected to a 10-day experiment as follows: Group 1 (negative control): 0.5ml saline (0.9%NaCl), intraperitoneally (IP) for 10 days. Group 2: 25 mg/kg lead acetate (Merck, Germany), IP for the last 5 days [14]. …”

Concentration of Heavy Metals and Health Risk Assessment of Consumption of Fish (Sarotherodon melanotheron) from an Estuarine Creek in the Niger Delta, Nigeria

“…The Target hazard quotient (THQ) for the metals in the current study showed that Cr > Pb > Cd > Cu > Ni with all the values < 1 suggesting minimal risk of non carcinogenic consequence but Cr showed higher potential health risk than other metals. THQ > 1 has been said to indicate potentials of non carcinogenic risk to human exposures [42,43,44] particularly with increase in metal exposure. The THQ of metals in this study (<1) agrees with the findings of [45] and [46] but disagreed with the findings of [47] who reported >1 THQ for Pb, Cr, and Hg in fish from the coast of India.…”