Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose

Mao, Genxiang; Deng, Hongkui; Yuan, Long-Guo; Li, Dian-Dong; Li, Yi-Yang Yvonne; Wang, Zhen

doi:10.1016/s0895-3988(10)60047-5

Cited by 94 publications

(49 citation statements)

References 21 publications

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“…[17][18][19][20] The present study clearly demonstrated that administration of D-gal caused a severe agingrelated appearance changes, including significant decrease in body weights and organ indexes. However, supplementation of Colla corii asini was able to partially reverse these adverse effects.…”

Section: ) D-galsupporting

confidence: 64%

Effect of Colla corii asini (E’jiao) on D-Galactose Induced Aging Mice

Wang

Liu

Cao

et al. 2012

Biological & Pharmaceutical Bulletin

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Colla corii asini (E'jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks. Colla corii asini was simultaneously treated to them once daily by intragastric gavage. Appetite, mental condition, body weight, and organ index were observed. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as levels of malondialdehyde (MDA) in serum, brain, and liver were determined by according assay kits. Western blotting analysis was used to detect p16 and p21 expression. Results indicated that Colla corii asini could improve appetite, mental condition, body weight, and organ condition of model mice, improve SOD, CAT, and GSH-Px activities, reduce MDA levels, and modulate agerelated genes expression in D-gal induced mice. Therefore, Colla corii asini may have effect to suppress the aging process through enhancing antioxidant activity, scavenging free radicals, and modulating aging-related gene expression.Key words Colla corii asini (E' jiao); anti-aging; D-galactose; antioxidant; aging-related gene Aging is a natural phenomenon, and it is always associated with diverse chronic diseases, including cancer, Parkinson's and cardiovascular diseases, etc.1,2) Anti-aging has already become a major public issue with the increasing elderly population in the world. The free radical theory of aging was conceived by Harman in 1956. 3) Abundant evidences suggest that oxidative stress plays a central role in the process of biological aging.4) Oxygen-derived free radicals exert detrimental effects on human, including peroxidation of membrane lipids, enzyme inactivation, DNA fragmentation, and activation of apoptosis.5) In addition, supplementation with antioxidants has been reported to be beneficial with respect to slowing this aging process.D-Galactose (D-gal) has been used to induce oxidative stress in vivo to mimic the natural aging in mice. D-Gal can be metabolized at normal concentration, but when at high levels, it can be converted into galactitol under the catalysis of gal oxidase, resulting in the generation of superoxide anions and oxygen-derived free radicals.6) As one of the antioxidant defense systems, a group of enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), act as superoxide anion and H 2 O 2 scavengers to prevent reactive oxygen species (ROS)-induced damage, which may cause the changes of some biomarkers.7) Malondialdehyde (MDA) is a major biomarker that appears during the final stages of lipid peroxidation initiated by excessive ROS. An increase in the hepatic MDA concentration suggests th...

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Section: ) D-galsupporting

confidence: 64%

Effect of Colla corii asini (E’jiao) on D-Galactose Induced Aging Mice

Wang

Liu

Cao

et al. 2012

Biological & Pharmaceutical Bulletin

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“…Therefore, the increased GFAP expression in the cerebral cortex and the level of cortical NT-3 are both often indicators of brain aging. 43,44 In the current study (Fig. 6), d-galactose induced a 20.0% increase in GFAP in the brain, compared with the sham control group; the OFE showed an effective inhibition of the increase in GFAP, but not acteoside.…”

Section: Effects Of Ofe and Acteoside On Aging-related Factorssupporting

confidence: 49%

Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model

Xiong

Mao

et al. 2016

Journal of Medicinal Food

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Osmanthus fragrans flower extract (OFE) is an organic extract from O. fragrans flower, which exhibits neuroprotective, free radical scavenging, and antioxidant effects. Therefore, the protective effect of OFE and acteoside against aging was studied. An aging ICR mouse model was established by chronically administering d-galactose (250 mg/kg) for 8 weeks. d-galactose induced spatial learning and memory impairments that were successfully inhibited by OFE and acteoside, which could shorten escape latency, improve platform crossing times, and increase zone time. The antioxidant potential of OFE and acteoside in vivo was evaluated by estimating the following: activities of antioxidant enzymes, such as glutathione peroxidase and aging-related enzyme, particularly monoamine oxidase; contents of lipid peroxidation methane dicarboxylic aldehyde, advanced glycation end products, and 8-hydroxy-2'-deoxyguanosine (a DNA damage product); and levels of nuclear factor-erythroid 2-related factor 2. OFE and acteoside also inhibited d-galactose-induced neurological aging by suppressing the increase in glial fibrillary acidic protein and neurotrophin-3. Considering the dose-dependent protective effects of OFE and acteoside, we concluded that OFE, rich in acteoside, was a good source of natural antiaging compounds.

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“…Salidroside (Sal, p-hydroxyphenethyl-β-D-glucoside, Figure 1(A)), which is extracted from Rhodiola rosea L., is a bioactive component possessing various functional properties, such as anti-aging [1], antifatigue [2], antiviral [3], antihypoxia [4], anticancer [5], cardioprotection [6], and strong antioxidative activities [7]. Sal has been widely applied in the food and medical industries in the form of oral solution, capsule, and powder.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside

Luo¹,

Peng²,

Deng

et al. 2015

International Journal of Food Engineering

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Chitosan microspheres (CsMs) that encapsulate salidroside (Sal) were prepared by the emulsion crosslinking method with naturally occurring genipin (Gp) and then examined for their in vitro release. Sal-loaded CsMs (Sal-CsMs) showed nearly spherical and smooth surfaces with internal voids. The particle size of Sal-CsMs ranged within 0.56-5.01 μm, and their encapsulation efficiency and loading capacity were beyond 77.58% and 23.29%, respectively. The stability of Sal improved after entrapment into the CsMs. The release rate of Sal from CsMs was initially rapid, followed by sustained release. The release behavior depended on the pH of the release medium. The main release mechanisms underlying the release procedure were anomalous behavior and Fickian diffusion. These results indicated that CsMs with a novel crosslinker of Gp was a potential carrier system for producing functional foods containing Sal.

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Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose

Cited by 94 publications

References 21 publications

Effect of <i>Colla corii asini</i> (<i>E’jiao</i>) on <small>D</small>-Galactose Induced Aging Mice

Effect of <i>Colla corii asini</i> (<i>E’jiao</i>) on <small>D</small>-Galactose Induced Aging Mice

Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model

Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside

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