Protein Binding Nanoparticles as an Integrated Platform for Cancer Diagnosis and Treatment

Abstract

Smart nanomaterials constitute a new approach toward safer and more effective combined anti‐cancer immunotherapy. In this study, polydopamine‐multiprotein conjugates (DmPCs) that can be used for targeted delivery of multiple proteins to cells, realize imaging and combine the advantages of multiple treatment methods (photothermal therapy, chemodynamic therapy, and immunotherapy) can be synthesized and characterized. Proteins, as biological agents, are frequently used in this context, given their low toxicity in vivo. To overcome protein instability and short half‐life in vivo, the use of several proteins in combination with selected nanomaterials to treat patients with melanoma is proposed. In addition to the synthesis and characterization of protein‐bound nanoparticles, it is further demonstrated that several proteins can be efficiently delivered to tumor sites. DmPCs have a wide range of potential adaptability, which provides new opportunities for proteins in the field of treatment and imaging.

Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing

“…Polydopamine-loaded iron (Fe/PDA) was obtained as described previously. [12] As shown in Figure 1a,d, Fe/PDA had an average diameter of 110 nm and a high degree of uniformity. GOx was then transplanted onto the surface of Fe/PDA via acylation.…”

“…GOx was then transplanted onto the surface of Fe/PDA via acylation. [12] To optimize the water stability and dispersibility of Fe/PDA@GOx, HA was coated on the surface by electrostatic adsorption. The resulting Fe/PDA@GOx and Fe/PDA@GOx@HA had average diameters of 150 nm (Figure 1b,e) and 170 nm (Figure 1c,f), respectively.…”

“…GOx converts glucose to gluconic acid and produces hydrogen peroxide, which acts as a substrate for Fe-catalyzed CDT. [12] In addition, the released and c) Fe/PDA@GOx@HA. TEM images of d) Fe/PDA, e) Fe/PDA@GOx, and f) Fe/PDA@GOx@HA.…”

pH/thermal dual-responsive multifunctional drug delivery system for effective photoacoustic imaging-guided tumor chemo/photothermal therapy

“…Polydopamine (PDA) is a kind of biomimetic material of mussel, which can be obtained by self-polymerization of dopamine in weak alkaline environment. 31 PDA has many excellent properties, such as simple preparation, good biocompatibility, and excellent photothermal properties. 32 The structure of PDA contains a large amount of catechol and primary and secondary amines, so that PDA can be adsorbed on the surface of most substances to form a layer of polyamine film.…”

A study on optical properties of various hot drug molecules by 2020

“…10 Although some studies combining imaging and multiple treatment methods have been reported, there are still problems, such as complicated syntheses, low bioavailability or poor permeability, and none is in the clinical application stage. [11][12][13][14] Thus, a small organic drug molecule with near-infrared (NIR) fluorescence imaging ability has significance for promoting the clinical applications of integrated diagnosis and treatment.…”