Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study

Lee, Young In; Kim, Tae Hyun; Kim, Jemin; Choi, Se‐Young; Jung, Il‐Won

doi:10.3390/ijms221910189

Cited by 14 publications

(5 citation statements)

References 28 publications

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“…This crosslinking is completed by varying enzymes including transglutaminases and lysyl oxidases [ 140 ]. Wound resolution begins as the amount of extracellular collagen increases and fibroblasts decrease their collagen production [ 43 , 141 ]. During the course of a year, type III collagen is replaced by type I collagen through regulation by matrix metalloproteinases (MMPs) [ 142 , 143 ].…”

Section: Remodelingmentioning

confidence: 99%

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

2022

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The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins. Studies have demonstrated the ECM aids in cellular adherence, tissue anchoring, cellular signaling, and recruitment of cells. During times of integumentary injury or damage, either acute or chronic, the ECM is damaged. Through a series of overlapping events called the wound healing phases—hemostasis, inflammation, proliferation, and remodeling—the ECM is synthesized and ideally returned to its native state. This article synthesizes current and historical literature to demonstrate the involvement of the ECM in the varying phases of the wound healing cascade.

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Section: Remodelingmentioning

confidence: 99%

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

2022

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“…The remodeling phase continues for one to several years (36,37). In the remodeling phase, turnover of collagen decreases (38)(39)(40), and the generation and degradation of collagen decline (38).…”

Section: Discussionmentioning

confidence: 99%

The EGF Motif With CXDXXXXYXCXC Sequence Suppresses Fibrosis in a Mouse Skin Wound Model

Kitano

Ishikawa

Masaoka

et al. 2023

In Vivo

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Background/Aim: Fibrosis is an essential process for wound healing, but excessive fibrosis, such as keloids and hypertrophic scars, can cause cosmetic and functional problems. These lesions are caused by abnormal deposition and shrinkage of collagen fibers. The light chain of FIX, a plasma protein essential for hemostasis, has the amino acid sequence CXDXXXXYXCXC in the EGF domain. Peptides containing this sequence inhibited stromal growth in a mouse transplant tumor model. In this study, the effect of the FIX light chain on wound healing was studied. Materials and Methods: A full-layer wound was made on the back of each mouse, and cDNA encoding the light chain of mouse FIX (F9-LC) in an expression vector was injected locally once each week using a non-viral vector. Histochemical analysis of the wound was then performed to assess the effects on wound healing. Moreover, the effect of F9-LC on fibroblasts was studied in vitro. Results: Macroscopic observation showed that wounds with forced expression of F9-LC appeared flatter and had fewer wrinkles than control wounds. Tissue collagen staining and immunostaining revealed that administration of F9-LC suppressed collagen 1 and 3 deposition and decreased α-smooth muscle actin expression. Electron microscopy revealed sparse and disorganized collagen fibers in the F9-LC-treated mice. In experiments using fibroblasts, addition of a recombinant protein of the FIX light chain disrupted the typical spindle shape and alignment of fibroblasts. Conclusion: F9-LC is a new candidate for use in treatments to regulate excessive fibrosis and contraction in wound healing.

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“…Collagen peptides also attenuated inflammatory ailment by modulating Th2 cell activation via STAT1 pathway 10 , 11 . Further, oral intake of collagen peptide enhanced skin hydration and collagen density in UVB irradiation-induced skin model, clinical winkles patients, ex vivo, and hairless mice models 12 , 13 . Likewise, with previous studies indicating that fish collagen (FC) has anti-inflammatory, antioxidant, and anti-bacterial efficacy, FC exerts photoaging effects in melanocytes, skin fibroblasts, and hairless mice models 14 .…”

Section: Introductionmentioning

confidence: 90%

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

Kim,

Jin,

Lee

et al. 2023

Sci Rep

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Collagen, a major structural protein in mammalian tissues, is effective against skin wounds and osteoarthritis. Although bovine and porcine collagens have mainly been used, several potential risks of mammalian collagen have led to the use of fish collagen (FC) as an alternative. FC and its peptides are used as common cosmeceutical products because of their antihypertensive, anti-bacterial, and antioxidant activities. Despite the effects of FC on wrinkle reduction, UV-protection, and wound healing, the relationship between FC and atopic dermatitis (AD) has not yet been reported. Therefore, we investigated the anti-AD effects of FC against house dust mite (Dermatophagoides farinae, HDM)-induced AD in NC/Nga mice and TNF-α/IFN-γ-stimulated HaCaT keratinocytes. FC alleviated AD apparent symptoms, such as dermatitis score, transepidermal water loss, epidermal thickness, and mast cell infiltration upon declining pro-inflammatory cytokines and mediators, IL-6, IL-5, IL-13, TSLP, and TNF-α. The skin barrier protein, filaggrin, was also recovered by FC administration in vivo and in vitro. Immune response and skin barrier dysfunction are both mitigated by three routes of FC administration: oral, topical, and both routes via the regulation of IκB, MAPKs, and STATs pathways. In summary, FC could be a potential therapeutic agent for AD by regulating immune balance and skin barrier function.

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Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study

Cited by 14 publications

References 28 publications

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

The EGF Motif With CXDXXXXYXCXC Sequence Suppresses Fibrosis in a Mouse Skin Wound Model

Anti-atopic dermatitis effect of fish collagen on house dust mite-induced mice and HaCaT keratinocytes

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