Proteolytic activity of neutrophilic elastase as a prognostic factor of cardiovascular diseases development

Щупакова, А. Н.; Окулич, В. К.; Belyaeva, L.E.; Прудников, А. Р.

doi:10.22263/2312-4156.2016.2.17

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…33,43 The imbalance between NE activity and its inhibitors may be due to altered production of neutrophil elastase, changes in the level or activity of the circulating inhibitors, or both concurrently. 44 NE levels are raised in bronchoalveolar lavage fluid in patients with asthma. 45 Neutrophils in asthma patients secrete NE and MMP in response to viral and bacterial activity.…”

Section: Introductionmentioning

confidence: 95%

The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

Gb¹

2018

JLPRR

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Section: Introductionmentioning

confidence: 95%

The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

Gb¹

2018

JLPRR

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“…В дестабилизации АСБ также принимает участие НЭ, которая концентрируется в азурофильных цитоплазматических гранулах НФ [45]. Синтез НЭ происходит на стадии роста гранулоцитов, а в кровоток поступают клетки с уже готовыми ферментами.…”

Section: участие нф в атерогенезеunclassified

The role of neutrophils in the pathogenesis of atherosclerosis

Саранчина

Дутова

Килина

et al. 2018

Cardiovasc Ther Prev

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Atherosclerosis (AS) is one of the causes of cardiovascular disease. The formation of atherosclerotic lesions of the arteries is a long process, and clinical symptoms appear already at the stage of atherosclerotic plaque (ASB), which prevents blood flow and can cause coronary heart disease, as well as acute coronary syndrome. The study of atherosclerosis mechanisms at the subclinical level is relevant. This article provides a summary of current data on the structure and functions of neutrophils (NF) in physiological processes. Particular attention is paid to the participation of neutrophils in the damage and formation of vascular endothelial dysfunction. Discusses several mechanisms of involvement of neutrophils in atherogenesis: the production of reactive oxygen species, which cause direct endothelial damage; the synthesis of cytokines that trigger the migration of leukocytes in inflammation; the formation of protein complexes with cholesterol, contributing to their deposition in the vessels, and neutrophil traps, triggering destructivealterative reactions. Conflicts of interest: nothing to declare.Funding. The results were obtained in the framework of the state task № 17.9545.2017/BCh of the Ministry of education and science of Russia. Роль нейтрофилов в патогенезе атеросклерозаСаранчина Ю. В., Дутова С. В., Килина О. Ю., Ханарин Н. В., Кулакова Т. С. ФГБОУ ВО "Хакасский государственный университет им. Н. Ф. Катанова". Абакан, Россия Атеросклероз (АС) является одной из причин сердечно-сосудистых заболеваний. Формирование атеросклеротического поражения артерий -длительный процесс, а клинические симптомы проявляются уже на стадии атеросклеротической бляшки, которая стенозируя сосуд, препятствует кровотоку, и может вызвать ишемическую болезнь сердца, а также острый коронарный синдром. В связи с чем, изучение механизмов АС на субклиническом уровне является актуальным. В представленной статье приводятся обобщенные современные данные о строении и функциях нейтрофилов (НФ) в физиологических процессах. Особое внимание в обзоре уделено участию НФ в повреждении и формировании дисфункции эндотелия сосудов как одного из основных звеньев патогенеза АС. Обсуждается несколько возможных механизмов участия НФ в атерогенезе: продукция активных форм кислорода, вызывающих непосредственное повреждение эндотелия; синтез цитокинов, активирующих миграцию лейкоцитов в очаг воспаления; образование белковых комплексов с холестерином, способствующих их отложе-нию в сосудах, и формирование нейтрофильных ловушек, запускающих деструктивно-альтеративные реакции. Ключевые слова: нейтрофилы, атеросклероз, атеросклеротическая бляшка, нейтрофильные ловушки, нейтрофильная эластаза, нейтрофильный желатиназо-ассоциированный липокалин.Конфликт интересов: не заявлен.Финансирование. Результаты получены в рамках выполнения государственного задания № 17.9545.2017/БЧ Минобрнауки России.Кардиоваскулярная терапия и профилактика. 2018;17(6):110-116 http://dx.

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“…It is known that in various reactions of inflammation and tissue destruction, the leading place is occupied by proteolysis processes [5]. As one of the main proteolytic enzymes, we studied neutrophil elastase (NE).…”

Section: Introduction / вступmentioning

confidence: 99%

Effectiveness of Lymphotropic Therapy in the Patients With Acute Appendicitis and Its Complicated Forms

Duzhyi

Shimko²,

Pyatikop

et al. 2023

EUMJ

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Introduction. Despite using the latest generations of antibiotics and modern methods of their introduction in the surgical treatment of acute appendicitis, purulent-septic complications keep occurring, accounting for 45% of fatal outcomes in the patients operated on for this disease. Materials and methods. Patients were divided into two groups. The main group included patients who were administered antibiotics and pathogenetic drugs locally to the ileocecal zone by means of lymphotropic administration. The comparison group included patients who received standard antibiotic therapy. Results. On the 5th day of the postoperative period, the level of IgA in the main group was 1.16 ± 0.7 mg/ml, and in the comparison group – 1.54 ± 0.8 mg/ml. The level of elastase in the operated patients of the main group decreased to 111.797 ± 21.39 nmol/min × ml, i.e., by 2.4 times (p <0.001), and in patients of the comparison group – to 179.605 ± 26.79 nmol/min × ml, i.e., by 1.5 times (p <0.05). Under the influence of lymphotropic administration of the antibiotic, the volume of the spleen decreased by the 5-th day to 281.22 ± 18.8 cm³, i.e., 145.44 cm³, and with standard administration of antibiotics, the spleen decreased within the period to 344.71 ± 21.13 cm³, i.e., by 79.54 cm³, which is less by 66 cm³, or 1.8 times (p <0.05) vs. main group. Conclusions. The proposed method of antibiotic therapy is a preventive measure against purulent-septic complications, especially in its destructive forms, improves the results of treatment of patients with acute appendicitis, and shortens their term of staying in the hospital, which has a positive impact on financial status.

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Proteolytic activity of neutrophilic elastase as a prognostic factor of cardiovascular diseases development

Cited by 6 publications

References 4 publications

The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

The role of neutrophils in the pathogenesis of atherosclerosis

Effectiveness of Lymphotropic Therapy in the Patients With Acute Appendicitis and Its Complicated Forms

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