Proteome analysis of gelatin-bound salivary proteins in patients with primary Sjögren's Syndrome

Ito, Kayoko; Funayama, Saori; Hitomi, Yasumasa; Nomura, Sadahiro; Katsura, Kouji; Saito, Maki; T, Hayashi; Kaneko, Noboru; Nohno, Kaname; Igarashi, Atsuko

doi:10.1016/j.cca.2009.03.018

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…MMP-9 involvement is further described for cardiovascular, respiratory and auto-immune diseases (e.g., Systemic Lupus Erythematosus, Sjögren's syndrome, Multiple Sclerosis, Rheumatoid Arthritis, polymyositis, asthma, chronic obstructive pulmonary disease, C protein-induced myocarditis, lupus nephritis, auto-immune inner ear disease and bullosus pemphigoid) Fenton et al, 2009;Hulkkonen et al, 2004;Ito et al, 2009;Ma et al, 2010;Matsumoto et al, 2009;Noseworthy et al, 2000;Pathak et al, 2011). In some cases, the molecular mechanisms underlying its pathogenic activity have been described in detail: therefore, the discussion of MMP-9 role in human pathologies will be limited to those more represented in literature (see Table 4).…”

Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

View full text Add to dashboard Cite

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“…Elevated FSTL1 levels occur in individuals with RA, ulcerative colitis, SLE, SS, SSc, and PM/ DM [ 34 ]. Elevated MMP9 levels occur in individuals with multiple sclerosis [ 35 ] and in individuals with SS [ 36 , 37 ]. IFNA1 is involved in the pathogenesis of SLE [ 38 ] and SS [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

A distinguishing profile of chemokines, cytokines and biomarkers in the saliva of children with Sjögren’s syndrome

Hernandez¹,

Starman

Davis³

et al. 2021

Rheumatology

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Objectives Sjögren’s syndrome is an autoimmune disease most commonly diagnosed in adults but can occur in children. Our objective was to assess the presence of chemokines, cytokines, and biomarkers (CCBMs) in saliva from these children that were associated with lymphocyte and mononuclear cell functions. Methods Saliva was collected from 11 children diagnosed with Sjögren’s syndrome prior to age 18 years and 16 normal healthy children. 105 CCBMs were detected in multiplex microparticle-based immunoassays. ANOVA and t test (0.05 level) were used to detect differences. Ingenuity Pathway Analysis (IPA) was used to assess whether elevated CCBMs were in annotations associated with immune system diseases and select leukocyte activities and functions. Machine learning methods were used to evaluate the predictive power of these CCBMs for Sjögren’s syndrome and were measured by receiver operating characteristic (ROC) curve and area under curve (AUC). Results 40.9% (43/105) CCBMs were different (p < 0.05) in children with Sjögren’s syndrome compared to the healthy study controls and could differentiate the two groups (p < 0.05). Elevated CCBMs in IPA annotations were associated with autoimmune diseases and with leukocyte chemotaxis, migration, proliferation, and regulation of T-cell activation. The best AUC value in ROC analysis was 0.93, indicating that there are small numbers of CCBMs that may be useful for diagnosis of Sjögren’s syndrome. Conclusion While 35/43 CCBMs have been previously reported in Sjögren’s syndrome, 8 CCBMs had not. Additional studies focusing on these CCBMs may provide further insight into disease pathogenesis and may contribute to diagnosis of Sjögren’s syndrome in children.

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“…In support of this result, the Gene Ontology analysis of the array data identified immune response and cellular defence response among highly ranked functions affected. Furthermore, given the role of MMP-9 in pSS pathogenesis [85][86][87] and the ability of GBPs to inhibit it as discussed in the earlier RA section, additional studies are needed that focus on differences in the expression profile of GBPs and whether experimental manipulation of their expression alters the central pathogenic mechanisms governing epithelial functions in pSS.…”

Section: Ramentioning

confidence: 99%

Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family

et al. 2020

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Human IFNs are secreted cytokines shown to stimulate the expression of over one thousand genes. These IFN-inducible genes primarily encode four major protein families, known as IFN-stimulated GTPases (ISGs), namely myxovirus-resistance proteins, guanylate-binding proteins (GBPs), p47 immunity-related GTPases and very large inducible guanosine triphosphate hydrolases (GTPases). These families respond specifically to type I or II IFNs and are well reported in coordinating immunity against some well known as well as newly discovered viral, bacterial and parasitic infections. A growing body of evidence highlights the potential contributory and regulatory roles of ISGs in dysregulated inflammation and autoimmune diseases. Our focus was to draw attention to studies that demonstrate increased expression of ISGs in the serum and affected tissues of patients with RA, SS, lupus, IBD and psoriasis. In this review, we analysed emerging literature describing the potential roles of ISGs, particularly the GBP family, in the context of autoimmunity. We also highlighted the promise and implications for therapeutically targeting IFNs and GBPs in the treatment of rheumatic diseases.

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Proteome analysis of gelatin-bound salivary proteins in patients with primary Sjögren's Syndrome

Cited by 10 publications

References 14 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

A distinguishing profile of chemokines, cytokines and biomarkers in the saliva of children with Sjögren’s syndrome

Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family

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