2006
DOI: 10.1186/1477-5956-4-9
|View full text |Cite
|
Sign up to set email alerts
|

Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble γ-glutamyl transpeptidase

Abstract: Background:In Drosophila melanogaster, the male seminal fluid contains proteins that are important for reproductive success. Many of these proteins are synthesised by the male accessory glands and are secreted into the accessory gland lumen, where they are stored until required. Previous studies on the identification of Drosophila accessory gland products have largely focused on characterisation of male-specific accessory gland cDNAs from D. melanogaster and, more recently, Drosophila simulans. In the present … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

3
39
1

Year Published

2006
2006
2020
2020

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 76 publications
(43 citation statements)
references
References 49 publications
3
39
1
Order By: Relevance
“…Not surprisingly the protein was identified only in male SGEs by MS. It is possible that this serpin plays a role in tick reproduction as does serpins in the seminal fluid of Drosophila [71, 72] and prostatic secretions of humans [73]. …”
Section: Resultsmentioning
confidence: 99%
“…Not surprisingly the protein was identified only in male SGEs by MS. It is possible that this serpin plays a role in tick reproduction as does serpins in the seminal fluid of Drosophila [71, 72] and prostatic secretions of humans [73]. …”
Section: Resultsmentioning
confidence: 99%
“…gambiae: one lipase and two carboxylesterases. Lipases are postulated to provide energy to sperm by hydrolysis of triglycerides (8). Like most lipases expressed in the MAGs of D. melanogaster, the Anopheles 03083 threads onto an acid lipase (SI Table 3), and it contains the active site (consisting of a catalytic triad and an oxyanion hole) characteristic of lipases (SI Fig.…”
Section: Lipid Transport Proteins (Cral-trio Domain Proteins)mentioning
confidence: 99%
“…Thus far 59 of the 112 Acps postulated to be present in the D. melanogaster genome have been identified, and a small number has been shown to play a role in reproduction (5)(6)(7)(8)(9)(10)(11). The majority of these genes encode proteins with secretory signal peptides and exhibit male-specific expression that is highly enriched in MAGs, two criteria used to define bona fide Acps (6,11).…”
mentioning
confidence: 99%
“…For these reasons, experimental identification of Sfps has been important. Previous studies predicted Sfps by sequencing expressed sequence tags (ESTs) from male accessory glands, which are the main secretory organs of the male reproductive tract (Wolfner et al 1997;Swanson et al 2001;Begun et al 2006), or by performing MS on proteins isolated from male reproductive tracts (Walker et al 2006). However, neither approach was able to determine with certainty which proteins are transferred by the male to the female.…”
mentioning
confidence: 99%