Proton-Beam Irradiated Epithelioid Cell Melanoma of the Ciliary Body

DNA Cell Cycle Studies In Uveal Melanoma

“…Nonetheless, they often contain viable-appearing tumor cells. [25][26][27][28][29][30][31][32] In studies ofseveral human malignancies, histologically monitored mitotic activity did not correlate with tumor growth.33 '34 In tumors such as uveal melanoma that have relatively slow doubling times, histologic studies of mitotic activity are insensitive measures of cell cycling. [35][36][37][38][39] A number of constraints have restricted the usefulness of tissue culture techniques to study the effectiveness of radiation therapy in uveal melanoma.…”

Ciliary Body and Choroidal Melanomas Treated by Proton Beam Irradiation

“…To our knowledge, there have been no histo¬ logie reports of eyes showing tumor regression after proton irradiation, and only one histologie and ultrastructural study of an eye that was enucleated after unsuccessful proton beam irradiation has been reported. 4 Recently we had the opportunity to perform histologie and ultrastructural studies on three eyes with uveal melanoma that showed clinical and/ or histopathological reduction in tumor size and were enucleated at varying intervals after proton beam irradiation.…”

Proton therapy for uveal melanomas and other eye lesions

“…Even those patients in the highest risk group had a 76 _+ 7% probability of retaining the irradiated eye five years after treatment [35]. Pathological changes in eyes enucleated after proton beam treatment have been described [36][37][38][39].…”