Protozoynye invasion of urogenital system in combine with bacterial vaginosis agents by women of fertil age and their sexual partners

Abstract

Study of protozoyny invazions of the uroganital system with combination of microorganisms which are associated with bacterial vaginosis by women of fertil age and their sexual partners men is perspective direction of modern medicine. The development of this direction can increase the level of diagnostic inspection of patients by transmissible mainly sexual way infections and improve of efficiency of their treatment. The objective: exposure of combine defeats of uroganital system with different kinds of trichomonas or lamblias and microorganisms which are associated with bacterial vaginosis, for the women of fertil age and their sexual partners – men. All patients have infections, transmissible mainly sexual way with a chronic process and their treatment. Materials and methods. The special research of biomaterial, taken from the urogenital system of women of fertil age and their sexual partners-men, patients infections, transmissible mainly sexual way with a chronic process is conducted. 198 patients were inspected in clinic. Used the method of PCR, amplifier of DT-96, reagents of «Femoflor-16», praymeris for the indication of Trichomonas vaginalis, Trichomonas tenax, Pentatrichomonas hominis and Giardia lamblia. Results. Protozoyny invasions of the urogenital system determined at 88 (44.4%) of patients. At 77 (38.8%) from them determined the differet kinds of trichomonadies: Trichomonas tenax – at 41 (20.7%), Pentatrichomonas hominis – at 28 (14.1%), Trichomonas vaginalis – at 8 (4%). Giardia lamblia determined from 11 patients (5.6%). For 92% inspected patients with a protozoal invasions were determined the increassng of indexes of microflora, associated with bacterial vaginosis. The treatment of combine pathology of urogenital system which are caused different kinds trichomonades and microorganisms, which associated with BV, were conducted with etiotropic therapy. Seknidox used 2 tablets one time per day during 5 days. Orcipol used 1 tablets 3 or 2 times per a day (depending on weight) during 10 days. In research took part 56 patients with chronic ITSW. By 54 patients (96.4%) were eliminated of trichomonas. The normalization microflora’s level is attained for a 31 (57.4%) patient. Decrease of mocroflora’s, which associated with BV is marked by 24 patients (42.6%). Conclusions. This original method of treatment, is effective, has satisfactory bearableness and can be recommended for empiric therapy of combined pathology of urogenital system, caused of protozoyny invasions (different kinds of trichomonas) and microorganisms, associated with bacterial vaginosis, for the women of fertil age and their sexual partners with chronic infections, transmissible mainly sexual a way. This agents have a certain role in development of diseases of the urogenital system. Key words: Trichomonas vaginalis, Trichomonas tenax, Pentatrichomonas hominis, Giardia lamblia, invasion, fertil age.

Clinical and epidemiological characteristics and morphological peculiarities of urogenital trichomoniasis nowadays

“…The practical relevance of the data presented is that determining the type of protozoa, as well as their morphological forms, plays a crucial role in preventing STI complications, recurrences and re-infections through the selection of adequate treatment and diagnostic and preventive measures [1,5,14,18].…”

“…This stipulates the possibility of prolonged persistence of bacteria, fungi and viruses, in particular the HIV agent within the tricho-monas, and explains the unsuccessful attempts to diagnose and eliminate the relevant microorganisms. In addition, it was reported that pathogenic microflora could block nitro groups in imidazole compounds, thus impeding the treatment of urogenital trichomoniasis [1,6,[12][13][14].…”

“…For a long time, only Trichomonas vaginalis was considered to be capable of living in the human urogenital tract. Today, the possibility of prolonged colonization and pathology of the human genitourinary system caused by both Trichomonas vaginalis and Trichomonas non vaginalis (Pentatrichomonas hominis and Trichomonas tenax) is proved [14,15].…”