Prunetin Protects Against Dexamethasone-Induced Pancreatic Β-Cell Apoptosis via Modulation of p53 Signaling Pathway

Kooptiwut, Suwattanee; Samon, Kanokwan; Semprasert, Namoiy; Suksri, Kanchana; Yenchitsomanus, Pa‐thai

doi:10.1177/1934578x20916328

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…A recent study of prunetionoside identified the essential targets on gastric cancer cells to be HSP90, CDK2, and MMP1 with their binding potential confirmed through molecular docking analysis (Vetrivel et al 2021). Kooptiwut et al (2020) reported that prunetin (aglycan form) protected dexamethasone-induced apoptosis of pancreatic cells in rat insulinoma (INS-1) cells through the p53 signaling pathway. Treatment with dexamethasone combined with prunetin considerably reduced Bax and Rb protein expressions while it increased the Bcl 2 protein expression (Kooptiwut et al 2020).…”

Section: Prunetionosidementioning

confidence: 99%

“…Kooptiwut et al (2020) reported that prunetin (aglycan form) protected dexamethasone-induced apoptosis of pancreatic cells in rat insulinoma (INS-1) cells through the p53 signaling pathway. Treatment with dexamethasone combined with prunetin considerably reduced Bax and Rb protein expressions while it increased the Bcl 2 protein expression (Kooptiwut et al 2020). Prunetin induced necroptotic cell death in AGS cells via RIPK3 provocation which leads to MLKL-phosphorylation and ROS generation (Vetrivel et al 2020).…”

Section: Prunetionosidementioning

confidence: 99%

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Glycosidic flavonoids and their potential applications in cancer research: a review

Abusaliya

Bhosale

et al. 2021

Mol. Cell. Toxicol.

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Purpose of review Every year, the cancer patient registry increases, and the leading cause of death in a global context. Plant-based molecules are gaining attention in cancer research due to the side effects of chemotherapy. A glycosidic derivative of flavonoid (GDF) plays a significant role in cancer proliferation mechanisms. GDF inhibits cell proliferation by elevating the expression of apoptotic proteins, altering the expression of nuclear factor-kappa B (NF- κB), and decreasing mitochondrial membrane potential (Δψm) in cancer cells. Recent findings Reported studies on the flavonoids orientin, vitexin, prunetionoside, chrysin, and scutellarein increased attention and are being widely investigated for their potential role in different parts of cancer research. Prunetionoside is a flavonoid with high cytotoxic potential and capable of inducing necroptosis in AGS gastric cancer cells. Similarly, scutellarein is a flavonol, induces an extrinsic apoptotic pathway and downregulates the expression level of cyclin proteins in HepG2 liver cancer cells. Vitexin is reported to be capable of deregulating the expression levels of p-Akt, p-mTOR, and p-PI3K in A549 lung cancer cells. Orientin inhibits IL-8 expression and invasion in MCF-7 breast cancer cells by suppressing MMP-9 in the presence of TPA via STAT3/AP-1/ERK/PKCα-mediated signaling pathways. It also induces mitochondria-mediated intrinsic apoptosis and G0/G1 cell cycle arrest in HT29 colon cancer cells. Chrysin is a flavonoid present in honey that has been shown to play an important role in cervical and colon cancer by suppressing the AKT/mTOR/PI3K pathway and increasing ROS accumulation, LDH leakage, respectively.

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Section: Prunetionosidementioning

confidence: 99%

Section: Prunetionosidementioning

confidence: 99%

Glycosidic flavonoids and their potential applications in cancer research: a review

Abusaliya

Bhosale

et al. 2021

Mol. Cell. Toxicol.

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“…PRU is widely known for its ability to inhibit the action of growth factors in vitro , as a strong tyrosine kinase inhibitor. Although PRU was reported to have a protective effect against dexamethasone-induced pancreatic beta cell apoptosis ( Kooptiwut et al ., 2020 ), effects of PRU on STZ-induced DN still remain uncertain. Insulin therapy is one of the therapeutic modalities used to treat diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Prunetin on Streptozotocin-Induced Diabetic Nephropathy in Rats - a Biochemical and Molecular Approach

Samy,

Kumar,

Singaravel

et al. 2023

Biomol Ther (Seoul)

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In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these may help to slow the onset of diabetic kidney disease. The anti-nephropathic effects of PRU have not yet been reported. The present study explored the potential nephroprotective actions of PRU in diabetic rats. For 28 days, nephropathic rats were given oral doses of PRU (20, 40, and 80 mg/kg). Body weight, blood urea, creatinine, total protein, lipid profile, liver marker enzymes, carbohydrate metabolic enzymes, C-reactive protein, antioxidants, lipid peroxidative indicators, and the expression of insulin receptor substrate 1 (IRS-1) and glucose transporter 2 (GLUT-2) mRNA genes were all examined. Histological examinations of the kidneys, liver, and pancreas were also performed. The oral treatment of PRU drastically lowered the blood glucose, HbA1c, blood urea, creatinine, serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, lipid profile, and hexokinase. Meanwhile, the levels of fructose 1,6-bisphosphatase, glucose-6-phosphatase, and phosphoenol pyruvate carboxykinase were all elevated, but glucose-6-phosphate dehydrogenase dropped significantly. Inflammatory marker antioxidants and lipid peroxidative markers were also less persistent due to this administration. PRU upregulated the IRS-1 and GLUT-2 gene expression in the nephropathic group. The possible renoprotective properties of PRU were validated by histopathology of the liver, kidney, and pancreatic tissues. It is therefore proposed that PRU (80 mg/kg) has considerable renoprotective benefits in diabetic nephropathy in rats.

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The Potential Therapeutic Properties of Prunetin against Human Health Complications: A Review of Medicinal Importance and Pharmacological Activities

Patel

2022

DMBL

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Background: Flavonoids are polyphenolic compounds found to be present in nature and abundant in flowers and fruits. Flavonoidal class phytochemicals have gained interest in the scientific field because of their important pharmacological activities. Several scientific studies have revealed anti-bacterial, anti-oxidant, anti-fungal, analgesic, anti-viral, anti-inflammatory, anti-tumor, anti-parasitic and anti-allergic activities of flavonoidal class phytochemicals. Prunetin is an O-methylated isoflavone that belongs to the phytochemical phytoestrogen class, found to be present in the licorice, red cherry, soybean and legumes. Methods: Biological potential and pharmacological activities of prunetin have been investigated in the present work through scientific data analysis of numerous scientific research works. Numerous literature databases have been searched in order to collect the scientific information on prunetin in the present work. Pharmacological activities of prunetin have been investigated in the present work through literature data analysis of different scientific research works. Scientific data have been collected from Google Scholar, Google, PubMed, Science Direct and Scopus. Analytical data on prunetin has been collected from literature sources and analyzed in the present work. Results: Scientific data analysis revealed the biological importance of prunetin in medicine. Prunetin was found to be present in the pea, peach, Oregon cherry, skimmed cheese, cheese, cow kefir and goat kefir. Prunetin is also present in the Prunus avium, Andira surinamensis, Butea superba, Dalbergia sympathetica, Ficus nervosa, Pterospartum tridentatum and Pycnanthus angolensis. Pharmacological data analysis revealed the biological importance of prunetin on bone disorders, cancers, especially hepatocellular carcinoma, urinary bladder cancer, gastric cancer, ovarian cancer, human airway, gut health and enzymes. Scientific data analysis revealed biological effectiveness of prunetin for their angiogenic effects, anti-inflammatory, anti-oxidant, anti-microbial, estrogenic and vasorelaxant potential. Analytical data revealed the importance of modern analytical techniques for qualitative and quantitative analysis of prunetin in the scientific fields. Conclusion: Scientific data analysis in the present investigation revealed the biological importance and pharmacological activities of prunetin in medicine.

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Prunetin Protects Against Dexamethasone-Induced Pancreatic Β-Cell Apoptosis via Modulation of p53 Signaling Pathway

Cited by 3 publications

References 52 publications

Glycosidic flavonoids and their potential applications in cancer research: a review

Glycosidic flavonoids and their potential applications in cancer research: a review

Effect of Prunetin on Streptozotocin-Induced Diabetic Nephropathy in Rats - a Biochemical and Molecular Approach

The Potential Therapeutic Properties of Prunetin against Human Health Complications: A Review of Medicinal Importance and Pharmacological Activities

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