Pseudotumors of the Spleen

Inflammatory pseudotumor (IPT) of the spleen is a rare benign tumor with unknown etiology. It causes problems in the diagnosis because of mimicking some hematopoetic malignancies. Here we report the case of a 36-yr-old woman complaining of nausea and insomnia. Laboratory investigations were limited to increase of leukocyte and thrombocyte count. Ultrasonography and magnetic resonance (MR) imaging showed circumscribed solid lobulated mass, measuring about 6.5 cm in diameter, located in the dorsal region of the spleen. Splenectomy was performed with the differential diagnosis including hamartoma and lymphoma of the spleen. Histological examination of the sharply demarcated splenic mass consisted of myofibroblasts and admixture of inflammatory cells. Immunohistochemistry and in situ hybridization were performed. IPT of the spleen was diagnosed. Epstein-Barr virus (EBV) was detected in the tumor by in situ hybridization. This rare entity is presented because of its clinical, radiological and pathological difficulties in the differential diagnosis.

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“…Twenty‐nine cases were mentioned by Ozkara et al (14). According to our research results, 53 new cases have been reported worldwide (15–47).…”

Section: Discussionmentioning

confidence: 83%

Inflammatory pseudotumor of the spleen with EBV positivity: report of a case

Puyan¹,

Bilgi²,

Ünlü³

et al. 2004

European J of Haematology

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“…It can theoretically occur in an accessory spleen; however, only 1 case has been reported so far. In this case, the accessory spleen was located in the splenic hilum [3]. Here we report a case of an inflammatory pseudotumor of the ''intrapancreatic'' accessory spleen, which mimicked a fibrous pancreatic mass with hemosiderin deposition.…”

Section: Introductionmentioning

confidence: 92%

Inflammatory pseudotumor of the intrapancreatic accessory spleen: computed tomography and magnetic resonance imaging findings

et al. 2011

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Inflammatory pseudotumor of the spleen is an uncommon benign mass-like lesion. It can occur in an accessory spleen, which may be found rarely in the pancreas tail. Here, we report the case of a 51-year-old woman with an inflammatory pseudotumor of the intrapancreatic accessory spleen mimicking a fibrous pancreatic mass with hemosiderin deposition. To the best of our knowledge, this is the first case report including radiological and histopathological findings of this extremely rare condition. In conclusion, inflammatory pseudotumor of an intrapancreatic accessory spleen should be regarded as a differential diagnosis in the case of a fibrotic mass with hemosiderin deposition located in the pancreas tail.

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“…Ishigami et al ( 166) observed 8 patients with pancreatic lymphoma and 21 patients with AIP to identify the point of imaging discrimination for the two diseases. They concluded that patients with AIP present with delayed enhancement with a capsule-like rim on CT and MRI, which was absent in the PPL imaging feature (166,198). In addition, elevated serum c-globulin levels, particularly immunoglobulin G, can be observed in almost all of the patients with AIP, but not in PPL patients (199).…”

Section: Differential Diagnosismentioning

confidence: 99%

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Wang

Wu²,

Zhang³

et al. 2022

Front. Oncol.

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Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

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Pseudotumors of the Spleen

Cited by 3 publications

References 29 publications

Inflammatory pseudotumor of the spleen with EBV positivity: report of a case

Inflammatory pseudotumor of the spleen with EBV positivity: report of a case

Inflammatory pseudotumor of the intrapancreatic accessory spleen: computed tomography and magnetic resonance imaging findings

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

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