Psoriasis in patients with mycosis fungoides: a clinicopathological study of 25 patients

Abstract

Our results support the opinion that the association between psoriasis and MF does exist. It is most possibly related to the chronic lymphocyte stimulation that occurs during psoriasis that eventually leads to a dominant clone and the evolution to CTCL. Our study suggests that apart from cases of early MF, which are being indeed misdiagnosed as psoriasis, there is another group of patients, where psoriasis truly coexists with - or even progresses to - MF.

The different faces of mycosis fungoides: results of a single‐center study

“…The comorbidity of psoriasis and MF has previously been reported . We have already published our experience in this topic in a series of 25 patients, which seems to remain one of the largest cohorts to date .…”

Cutaneous lymphomas appearing during treatment with biologics: 44 cases from the French Study Group on Cutaneous Lymphomas and French Pharmacovigilance Database

“…These scenarios challenge the current state of knowledge as psoriasiform MF has been described, emphasizing the link or the coexistence of these two dermatoses. The association of MF and psoriasis recently reported in 25 patients with psoriasis among 321 patients with MF, raises the combined hypotheses of overlapping forms of MF and psoriasis, influence of immunosuppressive agents and the same pathological pathways involving T helper 17. The predominance of patients using biologics for psoriasis in two recent series (less obvious in ours) suggests the aggravating or revealing role of biologics on pre‐existing MF.…”

Mycosis fungoides after treatment with tumor necrosis factor‐alpha inhibitors for psoriasis: progression or onset?

“…The link between psoriasis, MF, and anti‐TNF‐α agents remains elusive . The pathogenesis of both psoriasis and MF is strictly related to the abnormal function of skin‐homing T‐cells, specifically Th1 and Th17 populations; and several studies have identified an increased relative risk for lymphomas, including CTCLs, in psoriatic patients .…”

“…The link between psoriasis, MF, and anti‐TNF‐α agents remains elusive . The pathogenesis of both psoriasis and MF is strictly related to the abnormal function of skin‐homing T‐cells, specifically Th1 and Th17 populations; and several studies have identified an increased relative risk for lymphomas, including CTCLs, in psoriatic patients . The explanation underlying these results may lie on the chronic lymphocyte‐driven inflammatory state of psoriasis plus the use of immunosuppressive therapies, such as anti‐TNF‐α agents, helping select a malignant T‐cell clone, provoking the development of CTCL …”

“…Given the considerable clinical and histological overlap that early‐stage MF has with other inflammatory dermatoses including psoriasis, misdiagnosis has been recognized as a factor that may account for the higher risk of CTCLs seen in psoriatic patients . However, Donigan et al .…”