Psychobiology of persistent antisocial behavior: Stress, early vulnerabilities and the attenuation hypothesis

Susman, Elizabeth J.

doi:10.1016/j.neubiorev.2005.08.002

Cited by 302 publications

(359 citation statements)

References 115 publications

(120 reference statements)

Supporting

Mentioning

323

Contrasting

Unclassified

Order By: Relevance

“…This process is called allostatic load and may result in serious pathophysiology. For example, exposure to family adversity early in life may affect the balanced functioning of the child's neurobiological system and this may result in the development of psychological problems (Cicchetti, 2002;Susman, 2006).…”

Section: The Hpa Axismentioning

confidence: 99%

Cortisol and externalizing behavior in children and adolescents: Mixed meta‐analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior

Alink

IJzendoorn

Bakermans‐Kranenburg

et al. 2008

Developmental Psychobiology

316

303

View full text Add to dashboard Cite

An inverse relation between cortisol (re)activity and externalizing behavior has been hypothesized, but research findings seem equivocal. We tested this hypo(re)activity hypothesis in two meta-analyses, one for basal cortisol (k ¼ 72 studies, N ¼ 5,480) and one for cortisol reactivity to a stressor (k ¼ 29 studies, N ¼ 2,601). No association was found between cortisol reactivity and externalizing behaviors (r ¼ À.04, 95% CI ¼ À.11, .02). However, the relation between basal cortisol and externalizing behavior was significant but small (r ¼ À.05, 95% CI ¼ À.10, À.002). The age of the children significantly moderated this relation: Externalizing behavior was associated with higher basal cortisol (hyperactivity) in preschoolers (r ¼.09, 95% CI ¼ .002, .17), and with lower basal cortisol (hypoactivity) in elementary school-aged children (r ¼ À.14, 95% CI ¼ À.19, À.08). There was no significant relation between cortisol and externalizing behavior in adolescents. ß

show abstract

Section: The Hpa Axismentioning

confidence: 99%

Cortisol and externalizing behavior in children and adolescents: Mixed meta‐analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior

Alink

IJzendoorn

Bakermans‐Kranenburg

et al. 2008

Developmental Psychobiology

316

303

View full text Add to dashboard Cite

show abstract

“…This circadian rhythm emerges as a result of several ACTH driven pulses of cortisol, which are themselves under the control of several sources of influence coordinated by the central nervous system (Vis et al, 2012). Diurnal cortisol secretion receives a great deal of attention because of its proposed impact on a wide range of physical, psychological and behavioral difficulties (Fries et al, 2005;Susman, 2006). Central to this hypothesis is the great disparity in basal secretion between individuals of all ages, including in the pattern of change of cortisol during the day (Smyth et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins

Ouellet‐Morin

Brendgen

Girard

et al. 2016

Psychoneuroendocrinology

View full text Add to dashboard Cite

Introduction: By and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion may vary according to the time of day. A direct test of this possibility has, however, not yet been performed. Objective: To describe the specific and common etiology of the CAR, awakening level and cortisol change from morning to evening in an agehomogenous sample of twin adolescents. Methods: A total of 592 participants of the Québec Newborn Twin Study, a population-based 1995-1998 cohort of families with twins in Canada, have collected saliva at awakening, 30 minutes later, at the end of afternoon and in the evening over four collection days.Results: Multivariate Cholesky model showed both specific and common sources of variance between the CAR, awakening and cortisol diurnal change. The CAR had the strongest heritability estimates, which, for the most part, did not overlap with the other indicators. Conversely, similar magnitudes of genetic and environmental contributions were detected at awakening and for diurnal change, which partially overlapped. Conclusion: Our study unraveled differences between the latent etiologies of the CAR and the rest of the diurnal cycle, which may contribute to identify regulatory genes and environments and detangle how these indicators each relate to physical and mental health.

show abstract

“…Parents with criminal records have a lower heart rate, which is also found in their offspring (40). Men have a lower heart rate than women (41), which may, at least partially, explain their higher involvement in antisocial behaviors. There are two main interpretations of reduced autonomic activation in antisocial behaviour.…”

Section: Autonomic Arousal and Violence In Children And Adolescentsmentioning

confidence: 92%

“…Serotonin is a widely distributed neurotransmitter in the brain, with a high density of receptors in the prefrontal cortex. It appeared early in evolution and is involved in many biological processes, including learning and memory, mood regulation, food intake, sleep, play, circadian rhythms and social behaviour (41). It has long been associated with aggressiveness (particularly reactive) and impulsivity.…”

Section: Neurotransmitter Systems and Violence In Children And Adolesmentioning

confidence: 99%

“…Zuckerman (15) also emphasizes that antisocial behaviour in psychotic subjects is in relation to deficits in the serotonergic and noradrenergic system, which facilitates behavioural disinhibition, impulsivity and sensation seeking behaviour. Low MAO activity is also related to aggressiveness, while the interaction of serotonin and this enzyme with experiences in early childhood increases the risk of antisocial behaviour in adulthood (15,41). There is also an interaction between serotonergic and the HPA axis (28).…”

Section: Neurotransmitter Systems and Violence In Children And Adolesmentioning

confidence: 99%

See 1 more Smart Citation

Neurobiology of violence in children and adolescents

Šimić

2013

Pediatr Today

View full text Add to dashboard Cite

This paper gives a brief insight into the basic concepts of biological theories of personality with the purpose of understanding the personality profile of risk for antisocial behaviour in children and adolescents. The interest for the biological processes underlying the different personality traits and psychopathology in children and adolescents has increased in recent years. Therefore, the aim of this review is to summarize the results of the previous studies on the role of the personality and following neurobiological systems: testosterone, hypothalamic-pituitary-adrenal gland axis, autonomic nervous system and monoamine neurotransmitters in violent behaviour in children and adolescents. The effect of interaction of different biological and psychosocial factors, possible interpretations, as well as directions for further investigations are also pointed out. Conclusion -Biological processes play a key role in the genesis of violent behaviour. However, further research should also take into consideration the complexity of their interactive relationship and the impact of various adverse environmental factors.

show abstract

Psychobiology of persistent antisocial behavior: Stress, early vulnerabilities and the attenuation hypothesis

Cited by 302 publications

References 115 publications

Cortisol and externalizing behavior in children and adolescents: Mixed meta‐analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior

Cortisol and externalizing behavior in children and adolescents: Mixed meta‐analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior

Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins

Neurobiology of violence in children and adolescents

Contact Info

Product

Resources

About