The knowledge society of today is linked to each field of human activity, hence it opens up every reference source and creates quite a number of prospects for personal and vocational advancement for any member of the educational process. Fast educational environment digitalization offers new opportunities for the employment and development of distance and blended teaching modes. In spite of the fact that today’s students are ready to employ the newest information technologies, complete transition to online teaching makes its impact on interpersonal relations. This article studies destructive attitudes and tolerance for stress in students’ interpersonal relations in the information educational environment. The work analyses available psychological investigations of destructive attitudes; it scrutinizes the basic approaches to the studies of tolerance for stress. 60 university students aged between 18 and 25 make the empirical object. The study results in an evidence of the proposed hypothesis; students’ destructive attitudes in interpersonal relations are defined; the level of tolerance for stress is revealed; personal characteristics are studied; interconnection between destructive attitudes, tolerance for stress and students’ personality characteristics is specified. The obtained results might be applied by educational psychological aid experts in their correctional activities aimed at validation of students’ tolerance for stress and interpersonal communication effectiveness.