Psychotropic effects of enalapril maleate in normal volunteers

Olajide, Dele; Lader, Malcolm

doi:10.1007/bf00432232

Cited by 35 publications

(21 citation statements)

References 3 publications

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“…Angiotensin-converting enzyme inhibitors like enalapril reduce blood pressure by a mechanism unrelated to that of 1-adrenoceptor blockers. The possible central effects of these drugs have not yet been evaluated, although in a recent study it was found that they enhanced attention and alertness (Olajide & Lader, 1985).…”

Section: Introduction Methodsmentioning

confidence: 99%

Differential effects of atenolol and enalapril on memory during treatment for essential hypertension.

Lichter¹,

Richardson²,

Wyke³

1986

Brit J Clinical Pharma

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A randomized single‐blind study was designed to compare the performance on memory tests requiring recall of information relevant to everyday life of two groups of hypertensive patients. One group of 13 patients were taking a beta‐adrenoceptor blocker (atenolol) and the other group of 12 patients received the angiotensin‐converting enzyme inhibitor (enalapril). The results suggested that when compared with placebo the group of patients treated with enalapril showed no changes in memory function, whilst there was a mild, but consistent deficit in the group taking atenolol.

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Section: Introduction Methodsmentioning

confidence: 99%

Differential effects of atenolol and enalapril on memory during treatment for essential hypertension.

Lichter¹,

Richardson²,

Wyke³

1986

Brit J Clinical Pharma

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“…In 12 normal volunteers, enalapril had no effect on mood compared with placebo [25]. However, psychomo tor ability (as measured by tapping rate), alertness, and attention were enhanced.…”

Section: Depression and Maniamentioning

confidence: 90%

The Brain Renin-Angiotensin System and Behavior

Moore

Gershon

1990

Dement Geriatr Cogn Disord

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A renin-angiotensin system, controlled by the angiotensin-converting enzyme (ACE), exists in the brain and has many effects on animal and human behavior. We have reviewed the relevant basic and clinical literature because of the apparent importance of the system in mood and memory circuitry, and because drugs which inhibit ACE are of potential benefit in the treatment of many psychiatric disorders.

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“…There have been repeated reports in the literature of impairment of central nervous function, including memory (Solomon et al, 1983) and sleep (Betts & Alford 1985), following treatment with 13-adrenoceptor blockers, but there have been few studies with ACE inhibitors to assess their CNS activity. Olajide & Lader (1985) have, however, reported increased attention and alertness with enalapril. The aim of this study was to investigate under controlled conditions, some central nervous effects of the newly developed ACE inhibitor cilazapril as compared with the P-adrenoceptor blocker metoprolol and placebo.…”

Section: Introductionmentioning

confidence: 93%

Influence of cilazapril on memory functions and sleep behaviour in comparison with metoprolol and placebo in healthy subjects.

Dietrich¹,

Herrmann²

1989

Brit J Clinical Pharma

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1 In a controlled, randomized, double-blind study the influence of cilazapril and metoprolol on learning and memory functions and on sleep behaviour was investigated in healthy young volunteers under steady-state conditions. Twenty-three subjects were given either 2.5 mg cilazapril, 200 mg metoprolol, or placebo for 14 days in a latin square design separated by washout periods of 7 days. 2 To test memory functions different modalities-verbal, visual, numerical associative and two dimensional spatial memory were tested for recent anterograde recall, both shortterm (less than 10 s) and middle-term (up to 15 min) were selected. The test had a content similar to that used in daily life situations. The sleep behaviour was tested both by objective (all night sleep EEG) and subjective measures. 3 Neither antihypertensive drug had an observable influence on memory performance at the dosages used under steady-state conditions. However, sleep was disturbed during metoprolol, while cilazapril could not be differentiated from placebo. The effects of metoprolol on sleep behaviour were observed in the objective and subjective measures. There was more frequent awakening during the night with the subjective complaint of difficulties in sleeping through. 4 From this study it is concluded that cilazapril has no major effect on memory functions and sleep behaviour. This is only true for the dosages given and under steady-state conditions.

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Psychotropic effects of enalapril maleate in normal volunteers

Cited by 35 publications

References 3 publications

Differential effects of atenolol and enalapril on memory during treatment for essential hypertension.

Differential effects of atenolol and enalapril on memory during treatment for essential hypertension.

The Brain Renin-Angiotensin System and Behavior

Influence of cilazapril on memory functions and sleep behaviour in comparison with metoprolol and placebo in healthy subjects.

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