Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from the starfishes Fromia monilis and Celerina heffernani

Palagiano, Elio; Marino, Simona De; Minale, L.; Riccio, Raffaele; Zollo, Franco; Iorizzi, Maria; Carré, Jean Baptiste; Debitus, Cécile; Lucarain, Laetitia; Provost, Jean

doi:10.1016/0040-4020(95)00082-j

Cited by 90 publications

(105 citation statements)

References 10 publications

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“…Taurine derivative 676 was isolated from the starfish Certonardoa semiregularis collected off Gomun Island, Korea [222]. The sea stars Fromia monilis and Celerina heffernani from Caledonia contained relatively small quantities of the known sponge metabolites ptilomycalin A (677) and crambescidin 800 (678), together with celeromycalin (679), fromiamycalin (680), and compound 681, although it seems reasonable to question the biosynthetic origin of these metabolites [223]. An unusual dimeric dipeptide 682 was isolated from the sea star Pentaceraster regulus from India [224].…”

Section: Miscellaneousmentioning

confidence: 99%

“…Two reinvestigations of the starfish Culcita novaeguineae led to the isolation of six closely related steroidal glycosides, culcitosides C 2 -C 6 (218 -222, resp.) and culcitoside C 8 (223), all of which were identified by chemical degradation or interpretation of spectral data [29] [31]. Gomophia watsoni contained gomophioside B (224) [25].…”

Section: Review Chemical Constituents and Bioactivities Of Starfishmentioning

confidence: 99%

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Chemical Constituents and Bioactivities of Starfish

Dong

Tian

Yang

et al. 2011

Chemistry & Biodiversity

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Starfish have been the research topic in many chemical and pharmacological laboratories due to their complex secondary metabolites and diverse bioactivities. The aim of this review is to provide an up-to-date review on the chemistry and bioactivity of compounds isolated from all kinds of starfish to illustrate the chemodiversity and biological significance of these constituents, along with their geographical distribution where it is discernible.

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Section: Miscellaneousmentioning

confidence: 99%

Section: Review Chemical Constituents and Bioactivities Of Starfishmentioning

confidence: 99%

Chemical Constituents and Bioactivities of Starfish

Dong

Tian

Yang

et al. 2011

Chemistry & Biodiversity

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“…불가 사리 생물체는 스테로이드 외에 글리코겐 화합물, 퀴논계 화 합물, 알칼로이드 화합물, 당지질성 화합물, 인지질 등의 다양 한 생체물질로 구성되어 있어 의약 및 농업소재로서 활용 가 치가 높다고 알려져 있다 (Palagiano et al, 1995;de Marino et al, 1997;Choi et al, 2010). 우리나라 근해저에 서도 수산양식장에 막대한 피해를 주고 있는 해적생물인 불 가사리가 대량 번식하고 있는 실정으로서 이에 대한 대책마 련이 시급한 실정이나 불가사리의 주요 성분인 칼슘 성분을 이용한 사료 또는 비료 첨가제로서의 활용에 그치고 있다 (Lee et al, 1989 불가사리 추출물의 진딧물 살충기작을 조사하기 위해 추 출물이 처리된 진딧물을 투과전과현미경을 이용하여 분석하 였다 (Fig.…”

Section: Open Access Research Articleunclassified

Aphicidal Activity of Starfish (Asterina pectinifera) Extracts against Green Peach Aphid (Myzus Persicae)

Jang¹,

Yi²,

Jung³

et al. 2011

Korean Journal of Environmental Agriculture

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BACKGROUND: Starfish is one of major sea invertebrates that have become a serious economic threat to aquacultural farms in Korea. Much effort has sacrificed to reduce the economic losses of the farms by predatory starfish, including developing and searching biological resources for medicinal and agricultural purposes. In the present study, we investigated aphicidal activity of the extracts from the starfish Asterina pectinifera against green peach aphid. METHODS AND RESULTS: Fresh starfishes were cut into small pieces, homogenized and soaked in methanol. The methanol extracts were centrifuged and the resulting supernatant was subjected to aphicidal activity assays and a series of silica gel column chromatography. More than 70% mortality of aphids were observed by the extracts at a concentration of 1,000 mg/L, exhibiting dose-dependent mortality. TOF-MS analyses detected polyhydroxysteroid as a main aphicidal compound from the starfish extracts.Transmission electronic microscopy could demonstrate that the extracts with polyhydroxysteroid caused aphids death by affecting their epicuticular membrane.

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“…Thus, efcient use of star sh waste as a biological resource is desired as part of an ecological recycling system. The star sh are considered an extremely rich source of biologically active compounds, for example, steroidal glycosides, steroids, anthraquinones, alkaloids, glycolipids and phospholipids [3][4][5]. Generally, marine organisms re ect, to varying degrees, exogenous sources in their fatty acid components.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variations of Lipid Content and Composition in Starfish Asterias amurensis Lütken

2012

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The total lipid content, lipid classes and fatty acid composition in the internal organs of star sh (Asterias amurensis) were analyzed to determine the effects of seasons (winter and spring). The non-polar and polar lipid fractions obtained from star sh internal organs were analyzed through two seasons using thin layer chromatography (TLC) and gas liquid chromatography. Total lipid content of internal organs was 10.18% in spring and 8.21% in winter as wet weight basis. The predominant lipid class in spring was triglyceride whereas free fatty acids were the main lipid class in winter. The most abundant fatty acid of non-polar lipid fraction was eicosamonoenoic acid (C20:1) in spring having the highest proportion (29.2% of total fatty acid) as compared to the winter. Eicosapentaenoic acid (EPA) was also found signi cantly (P < 0.05) higher in spring compared to winter in the non-polar lipid fraction. On the other hand, comparatively lower amount of EPA was observed in spring than winter in the polar lipid fraction. Proportions of other fatty acids in non-polar and polar lipid fractions were also varied seasonally. This result might be useful for commercial production of lipid from internal organ of star sh with a view to potential use in food, pharmaceutical, cosmetics and other non-food industries.

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Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from the starfishes Fromia monilis and Celerina heffernani

Cited by 90 publications

References 10 publications

Chemical Constituents and Bioactivities of Starfish

Chemical Constituents and Bioactivities of Starfish

Aphicidal Activity of Starfish (Asterina pectinifera) Extracts against Green Peach Aphid (Myzus Persicae)

Seasonal Variations of Lipid Content and Composition in Starfish Asterias amurensis Lütken

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