Pu-erh Tea Suppresses Diet-Induced Body Fat Accumulation in C57BL/6J Mice by Down-Regulating SREBP-1c and Related Molecules

Abstract

Although pu-erh tea has been shown to suppress hyperlipidemia, it is unclear how it modulates fatty acid synthase expression in mice fed on a high-fat diet. We investigated the effects of a pu-erh tea extract (PTE) on diet-induced body fat accumulation. C57BL/6J mice were fed a control diet, a high-fat diet (HFD), and HFD supplemented with 0.225% or 0.45% PTE for 70 d. Supplementation with PTE reduced the body weight gain, and the abdominal and liver fat accumulation. A significant difference in the triglyceride level were observed between the HFD control and HFD+0.45% PTE groups. A PTE intake tended to decrease sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS) mRNA expression in the liver of the mice. These findings indicate that PTE reduced lipogenesis by down-regulating SREBP-1c and related molecules, leading to the suppression of body fat accumulation.

Oxidized tea polyphenols prevent lipid accumulation in liver and visceral white adipose tissue in rats

“…Compared with the results of previous studies, the inconsistency observed here might have been caused by the lower dose of OTPs or the shorter treatment time in our study. Most of the previous associated studies treated animals with Pu-erh tea extract for 8-12 weeks [27,28,30]. However, in our study, the rats were fed a high-fat diet containing OTPs for approximately 6 weeks.…”

“…The increase in the number of small lipid droplets in the cytoplasm of hepatic cells in the OTP group indicated fatty degeneration in the liver tissues of this group. Previous studies found that both Pu-erh tea and theabrownin suppressed lipid accumulation and slowed the rate of fatty degeneration in liver tissues [18,28]. The uptake of free fatty acids from the diet has been reported as one of the primary sources of liver-derived fatty acids [32].…”

“…These results suggest reduced fatty acid synthesis and fatty acid oxidation in the liver tissues of OTP-treated rats, which were mainly dominated by the transcriptional factors pparα and pparγ. Shimamura et al [28] reported that the intake of a Pu-erh tea extract tended to decrease srebp-1c and fas mRNA expression in the liver of mice. Their findings indicate that the Pu-erh tea extract reduced lipogenesis by down-regulating SREBP-1c and related molecules, leading to the suppression of body fat accumulation.…”

Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans

“…Several recent studies found that PTE down-regulated the expression of transcription factors SREBP-1c[ 46 ] and PPARγ[ 47 ], which both regulate the expression of scd-1 . In C .…”

Serum metabolomics analysis of rat after intragastric infusion of Pu‐erh theabrownin

“…A unique feature of this tea is that its fragrance increases with increasing shelf time. Studies have found that Pu‐erh tea also has physiological functions such as lowering blood lipid levels, anti‐obesity, anti‐diabetic and suppressing tumor growth . For these reasons, Pu‐erh tea has been popular worldwide, especially in Asia.…”