Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic–pituitary–testicular axis function in the rat

Lafuente, A.; Márquez, Nuria Ponce; Pérez‐Lorenzo, María; Pazo, David; Esquifino, Ana I.

doi:10.1016/s0278-6915(00)00077-6

Cited by 82 publications

(46 citation statements)

References 33 publications

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“…Cadmium-induced peroxidation caused the release of free oxygen radicals (Llobert et al 1998). These free radicals cause the stimulation and destruction of sensitive macromolecules and indeed tissues (Lafuente 2000).…”

Section: Introductionmentioning

confidence: 99%

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Obianime

Byron²

2010

Nig. J. Phys Sci

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Summary:The effects of different doses of cadmium (CD) on some biochemical, hormonal and histopathological parameters of the liver, kidney and testes of the Wister rate were investigated. Cadmium (CD) in the dose range 0-40mg/kg while causing a time-and dose-dependent decrease of the basal serum levels of alkaline phosphatese (ALP) also caused a dose-dependent increase in the serum concentration of the acid and prostatic acid phosphatases. The value of the ALP changed from 148.7±1.0 IU/L in the control to 53.7±0.098 at 40mg/kg of cadmium. While the ACP and ACPT changed from 32.6±0.72 and 7 ±Units in the control to 54 and 17 units respectively at 40mg/kg of CD. Furthermore Cadmium also caused positively correlated dose-and time-dependent destruction of the histology of the liver, kidney and testes. These were characterized by vascular congestion, vacuolation, destruction of the seminal epithelial layers, focal necrosis of nucleus, Oedema of the seminal epithelia layers, focal necrosis of nucleus, oedema of the seminiferous tubules and reduction of spermatogenesis. CD also caused granular and eosinophilic cytoplasm, enlargement of sinusoids with kupffer cells, haemorrhage and apoptosis of cells. Finally pre-treatment with vitamin C (0.0015/kg), vitamin E (1.51/gm) and selenium (0.25mg) which on their own had little or no effects on the serum basal phosphatases, hormonal and histological stability caused a reversal of the cadmium-induced biochemical, hormonal and histological toxicities of the liver, kidney and testes. These results may be explained by the oxidational/antioxidational properties of these xeonobiotics and their mechanisms of actions.

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Section: Introductionmentioning

confidence: 99%

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Obianime

Byron²

2010

Nig. J. Phys Sci

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“…Several mechanisms of Cd-induced testicular toxicity have been proposed. Lafuente et al [5] reported increased Cd accumulation in the hypothalamus, pituitary, and testis and decreased plasma levels of follicle stimulating hormone in rats, suggesting a possible effect of Cd on the hypothalamic-pituitary-testicular axis. Previous data also, suggests that reactive oxygen species (ROS) are involved in Cd-induced testicular damage [6].…”

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confidence: 99%

Preventive Effect of Zinc Against Cadmium-induced Oxidative Stress in the Rat Testis

Abdelmelek²,

et al. 2008

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Abstract. The aim of this study was to investigate the antioxidant role of zinc (Zn) in the Cd-exposed testes of Wistar rats. Subchronic exposure to Cd (CdCl2, 40 mg/l, per os) for 30 days resulted in a significant reduction in growth rate (-11%) and relative weights of testes (-36%) and seminal vesicles (-80%). Treated rats displayed a decrease in testicular and plasma testosterone levels, respectively (-70%, P<0.05; -48%, P<0.05), epididymal sperm count (-22%, P<0.05), and spermatozoa motility (-35%, P<0.05). In contrast, Cd increased the malondialdehyde (+46%, P<0.05), metallothionein (+200%, P<0.05), and 8-oxodGuo concentrations (+71%, P<0.05) in the testis. In the gonad, Cd decreased the GPx (-30%, P<0.05), CAT (-32%, P<0.05), mitochondrial Mn-SOD (-34%, P<0.05), and cytosolic CuZn-SOD (-32%, P<0.05) activities. Zinc supplementation (ZnCl2, 40 mg/l, per os) in the Cd-exposed rats restored the activities of GPx, CuZn-SOD, and Mn-SOD in the testes to the levels of the control group. Moreover, zinc administration was capable of reducing the elevated levels of malondialdehyde in the testis. Interestingly, zinc supplementation attenuated DNA oxidation induced by Cd in the gonad and restored the testosterone level and sperm count to the levels of the control group. Zinc administration minimized oxidative damage and reversed the impairment of spermatogenesis and testosterone production induced by Cd in the rat testis.

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“…And these free radicals cause the stimulation and destruction of sensitive macromolecular and indeed tissues (26) This had been reported to cause apoptosis, necrosis and cell proliferation (27,28). Different studies have shown that cadmium affects plasma gonadotropin level (29).…”

Section: Resultsmentioning

confidence: 99%

Use of green tea polyphenols in ameliorates cadmiumsulfate toxic effectson Wisterrat' s female reproductive system

Sa¹,

Al-Lebawi²

2014

IOSRJAVS

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Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic–pituitary–testicular axis function in the rat

Cited by 82 publications

References 33 publications

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

Preventive Effect of Zinc Against Cadmium-induced Oxidative Stress in the Rat Testis

Use of green tea polyphenols in ameliorates cadmiumsulfate toxic effectson Wisterrat' s female reproductive system

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