Introduction: Epilepsy is chronic brain disorder characterized by recurrent derangement of the nervous system due to sudden excessive disorderly discharge of the cerebral neurons. People living with epilepsy continue to suffer from enacted or perceived stigma that is based on myths, misconceptions, and misunderstandings that have persisted for many years. Therefore, this study aimed to assess the community general knowledge and attitude towards epilepsy. Methods: Community based cross sectional study was conducted to assess public general knowledge and attitude towards epilepsy and its associated factors using structured pretested questionnaire. Data was entered into Epi data version 3.1 and transported to SPSS version 21 further analysis. Both Bivariable and Multivariable Logistic Regression was done to identify associated factors. Odds Ratios and their 95% Confidence interval was computed and variables with p value less than 0.05 was considered significantly associated factors. Results: 596 study participants were participated with a response rate of 98%. Among the study participants 43.6 (95% CI: 39.6, 47.5) had poor knowledge and 41.3 (95% CI: 37.4, 45.1) had unfavorable attitude. Being secondary education, marital status, witnessed seizure, and heard the term epilepsy were showed statistically significant association with poor knowledge about epilepsy. Level of education, low average monthly income, not witnessed seizure, not heard the term epilepsy and distant from health facility showed statically significant association with the unfavorable attitude. Conclusion: In this study, Debre Berhan communities were found to have deficits in terms of general knowledge and attitude about epilepsy; and it should be given due attention.