Pulmonary Hyalinizing Granuloma Presenting as Multiple Cavitary Calcified Nodules

A Case of Pulmonary Hyalinizing Granuloma Associated with Posterior Uveitis

“…The nodules are often multiple and bilateral. Occasionally calcification or cavitation is present (Patel et al 1991). The CT scan of our patient's chest documented multiple parenchymal and subpleural nodules without cavitations and calcification.…”

Granuloma hialinizante de pulmão recidivante

“…(2,8) There have been reports of extrapulmonary manifestations affecting the kidneys, larynx, and skin. (9,10) In the case reported here, the patient presented with skin involvement, characterized by a subcutaneous nodule. The nodule was investigated through biopsy and diagnosed as osteoma cutis, examination of the excised lobe revealed a welldelineated, firm, grayish-white mass, presenting calcified areas and measuring 10.0 × 4.0 × 3.5 cm (Figure 2).…”

“…(6)(7)(8) Patients with pulmonary hyalinizing granuloma can be asymptomatic, in which case suspicion of the disease is raised by radiological findings, or can present with dry cough, dyspnea, nonspecific chest pain, fatigue, and hemoptysis. (9) The diagnosis is based on anatomopathological examination, the microscopic aspects of which indicate thick deposits of collagen (keloid-like lesions) arranged concentrically or irregularly distributed, presenting central hyalinization and supplanting the lung parenchyma. At the interface between the lesion and the adjacent parenchyma, there is an increase in cellularity, together with the presence of lymphoplasmacytic inflammatory cells; in addition, there can be formation of lymphoid aggregates and foreign body granulomas.…”

Non-diagnosed pulmonary hyalinizing granuloma (PHG) as a cause of sudden unexpected death

“…Several authors proposed that the lesions represent a continuing immune response to agents as fungal organisms (e.g. histoplasmosis) or tubercle bacilli [5,6,12,13,28,29,40].…”