Pulmonary tuberculosis increases the risk of lung cancer

Wu, Chengyuan; Hu, Hsiao Yun; Pu, Cheng Yun; Huang, Nicole; Shen, Hsi Che; Li, Chung Pin; Chou, Yiing Jenq

doi:10.1002/cncr.25616

Cited by 157 publications

(155 citation statements)

References 21 publications

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“…In fact, the most common "root causes" of cancer worldwide are thought to be due to infectious agents, such as in liver (HBV), 57 cervical (HPV), 58 nasopharyngeal (EBV), 59,60 lung (TB), 61 and stomach (H. pylori) 62 cancers. Similarly, chronic inflammatory diseases, such as scleroderma, 63 ulcerative colitis, 64 and Crohn's disease, 65 all predispose to the onset of cancer.…”

Section: 35mentioning

confidence: 99%

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

et al. 2011

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Section: 35mentioning

confidence: 99%

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

et al. 2011

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“…It is well known that there is a significant relationship between the history of pulmonary TB and the risk of LC (5,16). It has also been reported that there is a synergistic interaction with the daily amount and duration of smoking and the history of pulmonary TB.…”

Section: Discussionmentioning

confidence: 99%

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Köksal¹,

Kızılgöz²,

Özcan³

et al. 2017

Eurasian J Pulmonol

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Objective: The coincidence of tuberculosis (TB) and lung cancer (LC) at the initial diagnosis or the development of TB during the course of LC is a challenge in the management of both diseases. Herein we reviewed 10 LC patients who coincidentally had TB and evaluated the challenges in the management of both diseases. Methods:The files of patients were retrieved from an archive, and available study forms were completed. Results:The study included 10 LC and TB patients during a 4 year-period. The sites of TB were the lung (seven patients), mediastinal lymph nodes (LN) (one patient), cervical LN (one patient), and subcutaneous nodules (one patient). LC and TB were simultaneously diagnosed in four patients. The diagnosis of pulmonary TB was confirmed by sputum culture two months after LC diagnosis in four patients. TB was diagnosed later in the follow-up period in two patients. Only one patient with early-stage LC who had undergone surgical resection tolerated anti-TB therapy well. In one patient, TB caused the over-staging of LC. In one patient, LC had progressed during the course of anti-TB therapy. Hepatotoxicity was the leading adverse reaction due to anti-TB therapy. Conclusion:These patients highlighted the importance of considering TB in the course of LC, especially in countries with a high TB prevalence. TB may cause the advanced staging of LC at the initial diagnosis; chemotherapy may worsen the TB course or cause reactivation TB. Reactivation TB may be considered as the progression of LC without tissue diagnosis or sputum analysis. The tolerability of anti-TB therapy is poor in these patients.

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“…4 The simultaneous or sequential occurrence of pulmonary tuberculosis and Lung carcinoma in the same patient has been reported in various case series and case-control studies. (5)(6)(7)(8)(9)(10) It has been suggested that inflammation and pulmonary fibrosis caused by tuberculosis can induce genetic damage, which can increase lung carcinoma risk. (11)(12)(13) The increased occurrence of Lung carcinoma in patients with tuberculosis can also be related to infection-induced immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Pulmonary tuberculosis and lung cancer

et al. 2017

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CASEHistory: 72 year old female presented with breathlessness and cough for 4 months .She had history of decreased appetite. She is a known case of Diabetes mellitus and hypertension and is on medication for the same. No family history of similar complaints or chronic illness.Past history of hospitalisation in our hospital 2 months back for similar complaints for two weeks.H/o of intake of Antitubercular medication for last two months4 drugs HRZE (DOTS regime).Physical examination revealed pallor.There was no icterus, cyanosis, clubbing and bony tenderness.Heart rate-90/min,Respiratory rate 32/min.Respiratory distress present.use of accessory muscles of respiration present.Chest examination:Right side of chest appeared prominent. Breath sounds were decreased on right side of chest in mammary, infraaxillary, infrascapular area Bronchial breath sounds and whispering pectoriloquy were present on right mammary area and axilllary area.Systemic examination was normal.On Investigations:Patient had anemia with leucocytosis. Erythrocyte sedimentation rate was raised (64).Liver function tests and Renal function tests were within normal limits.Chest Xray (Fig:1,2)of patient showed consolidation initially which had progressed to pleural effusion in one month. ABSTRACTPulmonary Tuberculosis can co-exist with lung malignancy masking the underlying disorder leading to delay in diagnosis and management. Here we present an interesting case of a 72 year old female who on initial presentation was diagnosed with tuberculosisbut later developed plural effusion during treatment and on investigation was found to have an underlying lung malignancy.Introduction:Pulmonary Tuberculosis and lung carcinoma are the two co morbidities that have been shown in many studies to coexist. Many of Signs and symptoms of Pulmonary Tuberculosis mimics lung carcinoma and coexistence increases mortality and morbidity.So we are presenting a case which had pulmonary Tuberculosis and later developed carcinoma lung.

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Pulmonary tuberculosis increases the risk of lung cancer

Cited by 157 publications

References 21 publications

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

Is Tuberculosis a Challenge in the Management of Lung Cancer?

Coexistence of Pulmonary tuberculosis and lung cancer

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