Pulpal, Microvascular, and Tissue Pressure

Kj, Heyeraas

doi:10.1177/002203458506400414

Cited by 45 publications

(17 citation statements)

References 20 publications

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“…The occurrence of PAS-reactive PML and macrophages has been reported in the peripheral tissue during wound healing and inflammatory processes (Montagna et al 1987). The environment of the dental pulp, rich vascular supply, and low compliance (Heyeraas 1985) may contribute to such a rapid invasion of PAS-reactive PML.…”

Section: Discussionmentioning

confidence: 99%

Responses of immunocompetent cells in the dental pulp to replantation during the regeneration process in rat molars

et al. 2000

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Responses of immunocompetent cells to tooth replantation during the regeneration process of the dental pulp in rat molars were investigated by immunocytochemistry using antibodies to class II major histocompatibility complex (MHC) molecules (OX6 antibody), monocyte/macrophage lineage cells (ED1 antibody) and protein gene product 9.5 (PGP 9.5), as well as by histochemical reaction for periodic acid-Schiff (PAS). Tooth replantation caused an increase in both the number of OX6- and ED1-positive cells and their immunointensity in the replanted pulp, but almost all PGP 9.5-immunoreactive nerves diminished in the initial stages. By postoperative day 3, many OX6- and ED -immunopositive cells had accumulated along the pulp-dentin border to extend their cytoplasmic processes into the dentinal tubules in successful cases. Once reparative dentin formation had begun after postoperative day 7, OX6- and ED1-immmunopositive cells became scattered in the odontoblast layer, while reinnervation was found in the coronal pulp. The temporal appearance of these immunocompetent cells at the pulp-dentin border suggests their participation in odontoblast differentiation as well as in initial defense reactions during the pulpal regeneration process. On postoperative day 14, the replanted pulp showed three regeneration patterns: (1) reparative dentin, (2) bone-like tissue formation, and (3) an intermediate form between these. In all cases, PAS-reactive cells such as polymorphonuclear leukocytes (PML) and mesenchymal cells occurred in the pulp space. However, the prolonged stagnation of inflammatory cells was also discernible in the latter two cases. Thus, the findings on PAS reaction suggest that the migration of the dental follicle-derived cells into the pulp space and the subsequent total death of the proper pulpal cells are decisive factors for eliciting bone-like tissue formation in the replanted pulp.

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Section: Discussionmentioning

confidence: 99%

Responses of immunocompetent cells in the dental pulp to replantation during the regeneration process in rat molars

et al. 2000

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“…The end result of neurogenic inflammation is a transient increase of interstitial tissue pressure (61) and outward flow of dentinal fluid (65), which is considered protective as discussed above. If the pulp is healthy, excess interstitial fluid resulting from transient neurogenic inflammation will be absorbed into the circulatory or lymphatic system via edema-preventing mechanisms (66,67). If pulp is not capable of resolving the increased tissue pressure, increased levels of neuropeptides and persistent edema could contribute to pain and local necrosis (68,69).…”

Section: Neuropeptides Neurogenic Inflammation and Cariesmentioning

confidence: 99%

Innate Immune Responses of the Dental Pulp to Caries

Hahn

Liewehr

2007

Journal of Endodontics

197

170

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“…It is known that extra-pulpal mechanisms might also be involved in the pulpal blood flow regulation (Heyeraas, 1985). Extra-pulpal vasoconstrictions caused by systematic administration of NOS inhibitors may modulate the blood flow in vessels proximal and parallel to the pulpal circulation.…”

Section: Discussionmentioning

confidence: 99%