Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration

Mori, Fumihiko; Konno, Suguru; Hikichi, Taiichi; Yamaguchi, Yuji; Ishiko, Satoshi; Yoshida, Akitoshi

doi:10.1136/bjo.85.5.531

Cited by 83 publications

(68 citation statements)

References 19 publications

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“…The pulsatile component of ocular blood flow is primarily choroidal. 5 It has been clinically applied to investigate in various ocular diseases including glaucoma, 6,7 age-related macular degeneration, 8,9 diabetic retinopathy, 10,11 choroidal melanoma, 12 and retinal pigmentosa. 13 Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, diffuse goitre, ophthalmopathy, and rarely, dermopathy.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Tsai

Kau

Kao

et al. 2004

Eye

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Purpose Graves' ophthalmopathy (GO) is a cosmetically disfiguring and visionthreatening complication of Graves' disease (GD). We investigated the clinical application of pulsatile ocular blood flow (POBF) measurement for detection of clinically active GO. Methods In this prospective study, the OBF tonometer (OBF Labs, Wiltshire, UK) was used to measure POBF in 83 eyes of 83 patients with GD in two groups and 42 normal control subjects. Group A comprised 35 GD patients without ophthalmopathy, and group B composed 48 GD patients with ophthalmopathy. Results were compared with controls. Results Pulse amplitude, pulse volume, and POBF were significantly lower in group B than that in group A and controls (Po0.001). After adjusting for age, sex, systolic blood pressure, diastolic blood pressure, heart rate, intraocular pressure, and axial length, multivariate linear regression analysis showed that POBF was still significantly lower in eyes with GO (772.4 (SD 279.3) ll/min) than group A (1177.3 (SD 326.3) ll/min) and controls (1255.4 (SD 295.1) ll/min) (Po0.001). Conclusions These data show that the pulsatile ocular blood flow differences between the groups are relevant to the presence of GO. POBF measurement is a clinically useful adjunct for assessing the haemodynamic change in GO patients.

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Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Tsai

Kau

Kao

et al. 2004

Eye

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“…16 A group-wise comparison between exudative AMD, nonexudative AMD and age-matched controls in a Japanese cohort showed significant decrease in POBF in exudative AMD. 17 In addition, significant difference in POBF was found between eyes in asymmetric AMD in a Taiwanese group. 18 The POBF was found to be higher in eyes with choroidal neovascularisation (CNV) than in fellow eyes with drusen, suggesting a role for haemodynamic abnormalities in the development and progression of AMD.…”

Section: Introductionmentioning

confidence: 94%

Pulsatile ocular blood flow in asymmetric age-related macular degeneration

Sandhu

Sivaprasad

Shah

et al. 2006

Eye

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Purpose Ocular perfusion abnormalities have been proposed in the pathogenesis of age-related macular degeneration (AMD) with differences in pulsatile ocular blood flow (POBF) in eyes with asymmetric AMD in Japanese and Taiwanese patients. The purpose of our study was to observe POBF difference in the fellow eyes of Caucasians with asymmetric AMD. Methods This was a cross-sectional study comparing POBF in three groups of patients with asymmetric AMD in the fellow eyes: Group 1 (n ¼ 21) with drusen and active choroidal neovascularisation (CNV); Group 2 (n ¼ 18) with drusen and disciform scar; Group 3 (n ¼ 8) with CNV and disciform scar. The POBF was adjusted for intraocular pressure (IOP), pulse rate (PR), and axial length using multiple regression analysis. Generalised estimation equation model was used to include both eyes in each group. Results The geometric mean (95% confidence interval) POBF values were as follows: Group 1 with drusen 1097.9 ll/min (957.0, 1259.7) in one eye and the fellow eye with CNV 1090.1 ll/min (932.3, 1274.7); Group 2 with drusen 946.0 ll/min (794.2, 1126.7) and disciform scar 966.2 ll/min (780.3, 1196.4); Group 3 with CNV 877.1 ll/min (628.3, 1224.6) and disciform scar 767.2 ll/min (530.5, 1109.7). Adjusting for differences in axial length, pulse rate and intraocular pressure, no statistically significant difference in POBF was found between fellow eyes in the same subject. Conclusions POBF is not different between fellow eyes of Caucasian patients with asymmetric AMD. Eye (2007) 21, 506-511.

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“…21,22 Refractive error influences POBF values, with more myopic refractive errors producing lower POBF values, confirming the reports of previous investigations. 8,22,24 It has been proposed that the influence of refractive error on POBF relates to axial length 20,23,24 as mypoes tend to have greater ocular volume, choroidal thinning, and greater scleral elasticity. The median spherical equivalent refractive error in the male and female subjects reported here was 0.00 D (range À12.75 to þ 4.50 D).…”

Section: Comparison Of Pobf Of Indians With Europeans and Indians In mentioning

confidence: 99%

“…Since the median spherical error in the three ethnogeographical groups in the present study was emmetropia, axial length, and refractive error were considered unlikely causes of the much higher mean POBF values found in the present study compared with those in previous studies. 8,10,11,[20][21][22] Because POBF is indirectly measured using IOP pulse amplitude, heart rate differences, and blood pressure could influence it. Also blood pressure lowering medications could lower POBF and substances like nicotine and caffeine could increase blood pressure and thus increase POBF.…”

Section: Comparison Of Pobf Of Indians With Europeans and Indians In mentioning

confidence: 99%

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Comparison of pulsatile ocular blood flow in Indians and Europeans

Gunvant

Baskaran

Vijaya

et al. 2004

Eye

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Purpose To compare pulsatile ocular blood flow (POBF) in Europeans and Indians and provide reference values for a group of healthy Indians.Patients and Methods Measurement with the POBF Tonograph was performed on healthy Indian subjects in India (n ¼ 252). A further 80 subjects (40 of Indian descent and 40 Europeans) underwent measurements in Cambridge, England. The instrument used for measurement was the same for both the studies.Results The mean POBF in the Indians in India was found to be 1176 ll/min. The mean POBF value in the Europeans was found to be 1033 ll/min and that for Indians in England was 1061 ll/min. The difference between the POBF within groups was significant (one-way ANOVA Po0.05) with the POBF of Indians in India being higher than Europeans and Indians in the UK. The difference between the Europeans and Indians in the UK did not reach statistical significance.Conclusions POBF values in Indians living in India were found to be considerably higher than the previously published normal value of 650 ll/min in European studies and other studies for other racial groups. The reason for this apparent difference may be instrumentrelated rather than genetic because such a large difference was not observed when a comparison was performed in the UK. In addition, the results for both groups in our comparative study were still considerably higher than reported in previous studies. The POBF of Indians in India is slightly higher than the POBF of people of Indian ethnic origin in England.

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Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration

Cited by 83 publications

References 19 publications

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Pulsatile ocular blood flow in asymmetric age-related macular degeneration

Comparison of pulsatile ocular blood flow in Indians and Europeans

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