Pulsed electromagnetic fields accelerate functional recovery of transected sciatic nerve bridged by chitosan conduit: An animal model study

Mohammadi, Rahim; Faraji, Darab; Alemi, Hanieh; Mokarizadeh, Aram

doi:10.1016/j.ijsu.2014.11.004

Cited by 28 publications

(15 citation statements)

References 37 publications

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“…PEMF can not only promote the survival and neuronal differentiation of cells (18) but also control the migration orientation of Schwann cells (SCs) as well as the growth direction of regenerating axons (19–21). The stimulation efficacy of PEMF is influenced by many known factors such as the ubieties between PEMF generator and subjects (22), PEMF parameters (23), and exposure duration (24).…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

Zhu

Liu

et al. 2017

Front. Neurol.

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Circadian rhythm (CR) plays a critical role in the treatment of several diseases. However, the role of CR in the treatment of peripheral nerve defects has not been studied. It is also known that the pulsed electromagnetic fields (PEMF) can provide a beneficial microenvironment to quicken the process of nerve regeneration and to enhance the quality of reconstruction. In this study, we evaluate the impact of CR on the promoting effect of PEMF on peripheral nerve regeneration in rats. We used the self-made “collagen-chitosan” nerve conduits to bridge the 15-mm nerve gaps in Sprague-Dawley rats. Our results show that PEMF stimulation at daytime (DPEMF) has most effective outcome on nerve regeneration and rats with DPEMF treatment achieve quickly functional recovery after 12 weeks. These findings indicate that CR is an important factor that determines the promoting effect of PEMF on peripheral nerve regeneration. PEMF exposure in the daytime enhances the functional recovery of rats. Our study provides a helpful guideline for the effective use of PEMF mediations experimentally and clinically.

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Section: Introductionmentioning

confidence: 99%

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

Zhu

Liu

et al. 2017

Front. Neurol.

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“…Currently, the most popular medical technique for nerve repair is using autologous nerve to bridge the gap [ 3 , 4 ]. While the source of autologous tissue is very limited, a second surgery was always needed and some donor site morbidities might be induced during the autologous graft [ 5 , 6 ]. As a promising alternative to provide the mechanical support, more and more natural or synthetic biodegradable artificial scaffolds were used for the recovery of severed nerve, such as collagen, chitosan, silk, polyglycolic acid and Poly ( d , l -lactic acid) (PDLLA) [ 7–9 ].…”

Section: Introductionmentioning

confidence: 99%

Degradation characteristics, cell viability and host tissue responses of PDLLA-based scaffold with PRGD and β-TCP nanoparticles incorporation

Xiong

et al. 2016

Regen Biomater

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This study is aimed to evaluate the degradation characteristics, cell viability and host tissue responses of PDLLA/PRGD/β-TCP (PRT) composite nerve scaffold, which was fabricated by poly(d, l-lactic acid) (PDLLA), RGD peptide(Gly-Arg-Gly-Asp-Tyr, GRGDY, abbreviated as RGD) modified poly-{(lactic acid)-co-[(glycolic acid)-alt-(l-lysine)]}(PRGD) and β-tricalcium phosphate (β-TCP). The scaffolds’ in vitro degradation behaviors were investigated in detail by analysing changes in weight loss, pH and morphology. Then, the 3-(4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2 -H-tetrazolium bromide (MTT) assay and cell live/dead assay were carried out to assess their cell viability. Moreover, in vivo degradation patterns and host inflammation responses were monitored by subcutaneous implantation of PRT scaffold in rats. Our data showed that, among the tested scaffolds, the PRT scaffold had the best buffering capacity (pH = 6.1–6.3) and fastest degradation rate (12.4%, 8 weeks) during in vitro study, which was contributed by the incorporation of β-TCP nanoparticles. After in vitro and in vivo degradation, the high porosity structure of PRT could be observed using scanning electron microscopy. Meanwhile, the PRT scaffold could significantly promote cell survival. In the PRT scaffold implantation region, less inflammatory cells (especially for neutrophil and lymphocyte) could be detected. These results indicated that the PRT composite scaffold had a good biodegradable property; it could improve cells survival and reduced the adverse host tissue inflammation responses.

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“…There are a lot of studies evaluating the protective or therapeutic effects of various antioxidants related to the peripheral nerve injury model such as vitamin E, ubiquinone, L-carnitine and agmatine (1,22,33,38) or other substances such as cytidinediphosphocholine, rapamycin, tetanus toxin, platelet-rich plasma, insulin-like growth factor I, dexamethasone and acetyl salicylic acid (5,8,9,12,17,23,29,39), or some energy types such as low level laser irradiation and low-frequency magnetic fields (30,44).…”

Section: █ Discussionmentioning

confidence: 99%

Effects of alpha lipoic acid on motor function and antioxidant enzyme activity of nerve tissue after sciatic nerve crush injury in rats

Kocaoğlu

Aktaş²,

Zengi³

et al. 2017

Turkish Neurosurgery

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Pulsed electromagnetic fields accelerate functional recovery of transected sciatic nerve bridged by chitosan conduit: An animal model study

Abstract: PEMF combine with chitosan grafting could be considered as an effective, safe and tolerable treatment for peripheral nerve repair in clinical practice.

Cited by 28 publications

References 37 publications

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

Circadian Rhythm Influences the Promoting Role of Pulsed Electromagnetic Fields on Sciatic Nerve Regeneration in Rats

Degradation characteristics, cell viability and host tissue responses of PDLLA-based scaffold with PRGD and β-TCP nanoparticles incorporation

Effects of alpha lipoic acid on motor function and antioxidant enzyme activity of nerve tissue after sciatic nerve crush injury in rats

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