Pulsed quantum-cascade laser-based sensor for trace-gas detection of carbonyl sulfide

Wysocki, Gerard; McCurdy, Matt; So, Stephen; Weidmann, Damien; Roller, Chad; Curl, R. F.; Tittel, Frank K.

doi:10.1364/ao.43.006040

Cited by 57 publications

(33 citation statements)

References 19 publications

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“…Laser spectrometry-based devices for the detection of particular compounds (e.g. ethane carbon monoxide, carbonyl sulfide or nitric oxide) can also be used to investigate exhaled breath on a breath-to-breath basis (von Basum et al, 2003(von Basum et al, , 2005Wysocki et al, 2004) and have the potential to become small in the future (e.g. down to the size of a cigarette box).…”

Section: Discussionmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

691

531

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Section: Discussionmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

691

531

View full text Add to dashboard Cite

show abstract

“…In this region many molecules such as CO, H 2 O, NO, and CO 2 have strong absorption bands that might overlap spectrally. Because of the wavelength tunability of the QCLs, it is possible to scan over multiple absorption lines of different species and thus detect more than one gas simultaneously [2,3]. However, in tissue the absorption of constituents strongly limits the penetration depth in the midinfrared region (1:5-4 μm).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy

et al. 2008

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Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy Persson, Linda; Andersson, Mats; Lewander, Märta; Svanberg, Katarina; Svanberg, Sune General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy We report on a dual-diode laser spectroscopic system for simultaneous detection of two gases. The technique is demonstrated by performing gas measurements on absorbing samples such as an air distance, and on absorbing and scattering porous samples such as human tissue. In the latter it is possible to derive the concentration of one gas by normalizing to a second gas of known concentration. This is possible if the scattering and absorption of the bulk material is equal or similar for the two wavelengths used, resulting in a common effective pathlength. Two pigtailed diode lasers are operated in a wavelength modulation scheme to detect molecular oxygen ∼760 nm and water vapor ∼935 nm within the tissue optical window (600 nm to 1:3 μm). Different modulation frequencies are used to distinguish between the two wavelengths. No crosstalk can be observed between the gas contents measured in the two gas channels. The system is made compact by using a computer board and performing software-based lock-in detection.The noise floor obtained corresponds to an absorption fraction of approximately 6 × 10 À5 for both oxygen and water vapor, yielding a minimum detection limit of ∼2 mm for both gases in ambient air. The power of the technique is illustrated by the preliminary results of a clinical trial, nonintrusively investigating gas in human sinuses.

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“…A spectral region where absorptions of 12 CO 2 and 13 CO 2 in the exhaled breath have the same order of magnitude is depicted in Figure 3. An optimal light source to spectrally resolve the absorption lines in this spectral range is a quantum cascade laser (QCL) [14][15][16]. Our pulsed QCL from Alpes Lasers with a driver unit from neoplas control GmbH is tunable in a spectral window of about 2 cm´1 width within 10 ms by a voltage ramp (sweep) and a laser repetition rate of 100 kHz.…”

Section: Spectral Tuningmentioning

confidence: 99%

Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes

et al. 2016

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Abstract:The actual metabolic capacity of the liver is crucial for disease identification, liver therapy, and liver tumor resection. By combining induced drug metabolism and high sensitivity IR spectroscopy of exhaled air, we provide a method for quantitative liver assessment at bedside within 20 to 60 min. Fast administration of 13 C-labelled methacetin induces a fast response of liver metabolism and is tracked in real-time by the increase of 13 CO 2 in exhaled air. The 13 CO 2 concentration increase in exhaled air allows the determination of the metabolic liver capacity (LiMAx-test). Fluctuations in CO 2 concentration, pressure and temperature are minimized by special gas handling, and tracking of several spectrally resolved CO 2 absorption bands with a quantum cascade laser. Absorption measurement of different 12 CO 2 and 13 CO 2 rotation-vibration transitions in the same time window allows for multiple referencing and reduction of systematic errors. This FLIP (Fast liver investigation package) setup is being successfully used to plan operations and determine the liver status of patients.

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Pulsed quantum-cascade laser-based sensor for trace-gas detection of carbonyl sulfide

Cited by 57 publications

References 19 publications

Human exhaled air analytics: biomarkers of diseases

Human exhaled air analytics: biomarkers of diseases

Simultaneous detection of molecular oxygen and water vapor in the tissue optical window using tunable diode laser spectroscopy

Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes

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