Pumilanol, an antiprotozoal isoflavanol from Tephrosia pumila

Ganapaty, S.; Pannakal, Steve Thomas; Srilakshmi, G.; Lakshmi, P. Vinotha Boorana; Waterman, Peter G.; Brun, Reto

doi:10.1016/j.phytol.2008.09.006

Cited by 20 publications

(27 citation statements)

References 18 publications

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“…Mixture of MeOH and CHCl 3 or CH 2 Cl 2 (1:1) was also applied for extraction [37][38][39][40][41]. Other research groups extracted the plant materials with acetone [42][43][44], CHCl 3 [45,46], CH 2 Cl 2 [47][48][49][50] or diethyl ether [51] at room temperature. Successive extraction starting with petroleum ether or hexane, CHCl 3 , EtOAc and MeOH using soxhelt apparatus [52][53][54][55][56] was also reported.…”

Section: Extraction and Purificationmentioning

confidence: 99%

“…NOESY data were also utilized to analyse the relative stereochemistry of the isoflavanol pumilanol (29) ring C protons [46].…”

Section: D-nmrmentioning

confidence: 99%

“…Abruquinone D (239) and abruquinone K (241) were the most active against T. brucei rhodesiense [38]. Pumilanol (29), an isoflavan from Tephrosia pumila, exhibited significant antiprotozoal activities against T. brucei rhodesiense, T. cruzi and L. donovani [46]. Sophoronol C (164) and Sophoronol E (166) exhibited moderate anitplasmodial activity against the CQS D10 strain of P. falciparum [91].…”

Section: Flavonoids -From Biosynthesis To Human Healthmentioning

confidence: 99%

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Isoflavonoids

Foudah¹,

Abdel-Kader²

2017

Flavonoids - From Biosynthesis to Human Health

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Isoflavonoids are interesting class of natural products due to their positive effects on human health. Isoflavonoids include isoflavones, isoflavanones, isoflavans, rotenoids and pterocarpans. Although they are reported from many plant families, most isoflavonoids are produced by the subfamily Papilionaceae of the Fabaceae. Various chromatographic methods have been applied for the purification of isoflavonoids. Simple Ultra Violet (UV) absorption spectra as well as both One and two dimensional NMR (1D-and 2D-NMR) are critical for the identification of isoflavonoids. Each class of isoflavonoids has its unique feature in both 1 H-and 13 C-NMR that enable their proper characterization. High Resolution Mass Spectrometry (HRMS) is a substantial tool in such challenge. In vitro experiments indicated that isoflavonoids possess antioxidant, antimutagenic, antiproliferative as well as cancer preventive effects. Epidemiological studies provide support for some of these effects on human. Members of this class also are reported to have antimicrobial activity. In this chapter, isoflavones, isoflavanones, isoflavans, homoisoflavonoids and isoflavenes will be discussed in relation to their occurrence, methods of purification, spectral characters helpful in structure elucidation as well as their biological importance.

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Section: Extraction and Purificationmentioning

confidence: 99%

“…NOESY data were also utilized to analyse the relative stereochemistry of the isoflavanol pumilanol (29) ring C protons [46].…”

Section: D-nmrmentioning

confidence: 99%

Section: Flavonoids -From Biosynthesis To Human Healthmentioning

confidence: 99%

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Isoflavonoids

Foudah¹,

Abdel-Kader²

2017

Flavonoids - From Biosynthesis to Human Health

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“…Ambrozin et al isolated and evaluated the activity of two flavonoids from the leaf extract belonging to the Rutaceae (Conchocarpus heterophyllus) family against the trypomastigote form of T. cruzi Ganapaty et al isolated from the roots of Tephrosia pumila (Fabaceae) Pumilanol, which displayed promising anti T. cruzi activity and low cytotoxicity when compared to the reference compound [8]. Grecco et al isolated four flavonoids (4 -O-Methylscutellarein, Sakuranetin, Hispidulin, and Pectolinaringenin) from the Baccharis retusa (Asteraceae) plant and found two of these flavonoid compounds to be more potent than the reference drug [9][10][11][12]. Marin et al isolated quercetin glycosides from Delphinium gracile (Ranunculaceae), which were also evaluated against the amastigote form of Trypanosoma cruzi.…”

Section: Introductionmentioning

confidence: 99%

Trypanocidal Activity of Flavanone Derivatives

et al. 2020

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Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step synthetic procedure. According to recommended guidelines, the whole cell-based screening methodology was utilized that allowed for the simultaneous use of both parasite forms responsible for human infection. The majority of the tested compounds displayed promising anti-Trypanosoma cruzi activity and the most potent flavanone bearing a nitrofuran moiety was more potent than the reference drug, Benznidazole.

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“…[7] The plants of Tephrosia pumila (L.) Pers (TPP) was chosen for evaluating its anxiolytic and antidepressant activity due to its traditional use in the management of anxiety, stress, insomnia, hysteria, skin inflammation, cough and fever. The literature reports that antimicrobial activities, [8] antiprotozoal activity, [9] anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

Murthy¹

2017

WJPR

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Tephrosia pumila (L.) Pers (Leguminosae (Fabaceae)), is an herbaceous climber that has been generally utilized in Indian traditional medicine for the treatment of different central nervous system (CNS) disorders. Nevertheless, the available scientific information about this species is rare and there are no reports identified with its conceivable impact on the CNS. In this work, the effects of ethanolic extract of Tephrosia pumila (L.) Pers (TPP) were assessed in rats utilizing behavioral tests sensitive to clinically effective antidepressant and anxiolytic effects compounds. The extract (200 and 400mg/kg), administered intraperitoneally, was able to decrease the immobility time of rats dose-dependently when subjected to both tail suspension and forced swim tests for antidepressant activity and elevated Pluse maze test, actophotometer test for anxiolytic effect and the effects are comparable to that of standard drugs i.e., Diazepam (20mg/kg). Neither the extracts of TPP and Diazepam, at the doses tested, produced significant effects on locomotor activity when subjected to open field behavioral test. These results demonstrated that TPP had specifically antidepressant effects in vivo. In conclusion, the present study recommended that TPP extracts possessed potential antidepressant and anxiolytic effects which could be of therapeutic interest for using in the treatment of patients with depressive disorders.

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Pumilanol, an antiprotozoal isoflavanol from Tephrosia pumila

Cited by 20 publications

References 18 publications

Isoflavonoids

Isoflavonoids

Trypanocidal Activity of Flavanone Derivatives

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

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