Pure primary squamous cell carcinoma of the breast: A rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast

Gupta, Chakshu; Malani, Ashok K.; Weigand, Robert T.; Rangineni, Guatam

doi:10.1016/j.prp.2006.01.006

Cited by 67 publications

(88 citation statements)

References 14 publications

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“…Histologically, more than 90% of the tumor consists of squamous cells. 12 Other pathologists consider squamous cell carcinoma as an adenocarcinoma with a particularly high grade of squamous metaplasia. 13,18 Even if classified differently, these tumors share a particularly high degree of squamous metaplasia (.90%) and are defined as squamous cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

et al. 2008

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Abstract. Squamous cell carcinoma of the mammary gland is rare in both veterinary and human medicine. Whereas human metaplastic and squamous variants are known, the objectives of the current study were to ascertain the presence of such entities in canine mammary tumors and to distinguish them from other (epidermal, sweat gland) squamous tumors that may develop in the same area. A panel of antibodies (anticytokeratin [CK] 19, CK 14, CK 5/6, pancytokeratin, and vimentin) was used on 18 mammary gland malignancies with squamous features and 16 malignant skin tumors (11 squamous cell carcinomas of the skin and 5 sweat glands). Fifteen of the 18 mammary carcinomas were classified as metaplastic carcinomas, and the remaining 3 were classified as squamous cell carcinomas. The 2 most useful markers to establish the histogenesis of mammary tumors were pancytokeratin and CK 19. All other antibodies were equally expressed (CK 14 and 5/6) in all histotypes. The antibody panel discriminated primary epidermal squamous tumors (pancytokeratin positive and CK 19 negative) from gland-derived squamous neoplasms (pancytokeratin positive and CK 19 positive) but failed to distinguish primary mammary tumors from other squamous tumors of glandular origin.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

et al. 2008

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“…Cystic changes are observed in 50% of the cases [2,11,15]. In our experience, the average tumor size was 7.3 cm, with a range of 3.5 to 18 cm.…”

Section: Discussionmentioning

confidence: 70%

“…Like our patients, the tumor occurs very rarely as breast abscess. To the best of our knowledge, only six patients with these tumors, which presented clinically as breast abscess, have been reported previously [11]. There are no findings on mammography specific to this diagnosis, which may explain the more-advanced disease stage at diagnosis [12,13].…”

Section: Discussionmentioning

confidence: 92%

Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Znati

2010

J Med Cases

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Pure primary squamous cell carcinoma (PPSCC) of the breast is a rare neoplasm included in World Health Organization Classification of tumors (2003) in metaplastic breast cancer. It accounts for less than 0.1% of all breast carcinomas. We performed a retrospective review of all women diagnosed or treated as PPSCC, from January 2004 to June 2009 to assess clinical presentation, surgical and pathological findings, treatment and outcome. Eight patients were identified. The median age was 48.2 (range: 40 -57) years. The average tumor size was 7.3 cm, with a range of 3.5 to 18 cm. There were one well differentiated, three moderately differentiated and four poorly differentiated PPSCC. Two cases were stage IIA, two cases stage IIIA and three cases stage IIIB. Primary treatment was mastectomy in six patients and large local excision in one patient. There was lymph node (LN) involvement in one patient. Estrogen and progesterone receptors status and over expression of HER 2 were assessed and none tumors was positive. Cytokeratin 5/6 and/ or Cytokeratin 14 were positive in all tumors. All patients were treated by radiotherapy and chemotherapy. Though PPSCC of the breast is a very rare and aggressive disease, in our experience it's relatively frequent. Strict histologic criteria should be used to diagnose PPSCC, because they have significantly lower axillary lymph node metastasis, lower estrogen and PR positivity, and they are often treatment-refractory. The role of different new chemotherapy regimens needs to be explored.

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“…It should also be noted that a breast cancer diagnosis should always be suspected and excluded. Squamous cell carcinoma is a rare, aggressive tumor often associated to local and distant lymph node metastases; it is an exceptional finding, Moreover, as regards the tumor histological features, the acantholytic variant of squamous cell carcinoma seems to have the worst prognosis, with a risk of lymph node metastases, and a 5-year survival of about 64% (10). SCC of the breast has shown very little responsiveness to chemotherapy with cyclophosphamide, methotrexate, 5-fluorouracil and doxorubicin.…”

Section: Discussionmentioning

confidence: 99%

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

Punzo¹

2017

GHIR

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Pure primary squamous cell carcinoma of the breast: A rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast

Cited by 67 publications

References 14 publications

Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

Immunohistochemical Characterization of Mammary Squamous Cell Carcinoma of the Dog

Pure Primary Squamous Cell Carcinomas of the Breast: A Report of Eight Cases

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

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