Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra)

Gowda, Nagaraj; Goswami, U.; Khan, M. Islam

doi:10.1016/j.fsi.2008.01.002

Cited by 47 publications

(22 citation statements)

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“…It is highly stable at high temperature and under wider pH range. HSL is T-antigen specific, can distinguish a-from b-anomers (Gowda et al, 2008). In this article, we report our studies on induction of HSL upon immune challenging and its interaction with both gram-negative and gram-positive human pathogenic bacteria and demonstrate the involvement in innate immunity.…”

Section: Introductionmentioning

confidence: 88%

“…The HSL, T-antigen specific lectin was purified to homogeneity by two-consecutive hydrophobic interaction (phenyl sepharose) column chromatography (Gowda et al, 2008). Briefly, the coelomic fluid was collected from bacterial challenged sea cucumber animals on dissection, and processed immediately to separate coelom from coelomycetes.…”

Section: Purification Of the Lectinmentioning

confidence: 99%

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T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

Gowda

Goswami

Khan

2008

Journal of Invertebrate Pathology

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Section: Introductionmentioning

confidence: 88%

Section: Purification Of the Lectinmentioning

confidence: 99%

T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

Gowda

Goswami

Khan

2008

Journal of Invertebrate Pathology

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“…Sea cucumbers are also known to have impressive amounts of lectins [107,108], cerberosides [109,110], glycosaminoglycans [111–113], sterols and omega-6 sterols and omega-6 and omega-3 fatty acids (EPA and DHA) [45,114,115]. …”

Section: High-value Bioactives and Therapeuticsmentioning

confidence: 99%

High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review

2011

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Sea cucumbers, belonging to the class Holothuroidea, are marine invertebrates, habitually found in the benthic areas and deep seas across the world. They have high commercial value coupled with increasing global production and trade. Sea cucumbers, informally named as bêche-de-mer, or gamat, have long been used for food and folk medicine in the communities of Asia and Middle East. Nutritionally, sea cucumbers have an impressive profile of valuable nutrients such as Vitamin A, Vitamin B1 (thiamine), Vitamin B2 (riboflavin), Vitamin B3 (niacin), and minerals, especially calcium, magnesium, iron and zinc. A number of unique biological and pharmacological activities including anti-angiogenic, anticancer, anticoagulant, anti-hypertension, anti-inflammatory, antimicrobial, antioxidant, antithrombotic, antitumor and wound healing have been ascribed to various species of sea cucumbers. Therapeutic properties and medicinal benefits of sea cucumbers can be linked to the presence of a wide array of bioactives especially triterpene glycosides (saponins), chondroitin sulfates, glycosaminoglycan (GAGs), sulfated polysaccharides, sterols (glycosides and sulfates), phenolics, cerberosides, lectins, peptides, glycoprotein, glycosphingolipids and essential fatty acids. This review is mainly designed to cover the high-value components and bioactives as well as the multiple biological and therapeutic properties of sea cucumbers with regard to exploring their potential uses for functional foods and nutraceuticals.

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“…Sea cucumbers are rich in glycosides (2), especially triterpene glycosides, whose antifungal and antitumor activities have been demonstrated (3). These organisms also have considerable amounts of lectin (4,5), cerebroside (6), glycosaminoglycan (7,8), sterol and omega 6, fatty acids and omega 3. The natural compounds in marine organisms can be used as a source of compounds with nutritional, pharmaceutical, and medical applications (9).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Sea Cucumber (Stichopus variegatus) Body Wall Extract in Chabahar Bay, Oman Sea

Shakouri

Shoushizadeh

Nematpour

2016

Jundishapur J Nat Pharm Prod

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Purification and characterization of a T-antigen specific lectin from the coelomic fluid of a marine invertebrate, sea cucumber (Holothuria scabra)

Cited by 47 publications

References 47 publications

T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review

Antimicrobial Activity of Sea Cucumber (Stichopus variegatus) Body Wall Extract in Chabahar Bay, Oman Sea

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