Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro

Smith, Susan; Stillman, Bruce

doi:10.1016/0092-8674(89)90398-x

Cited by 656 publications

(661 citation statements)

References 27 publications

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“…They can function as molecular chaperones to promote nucleosome assembly and are involved in histone storage (Laskey et al 1978;Kleinschmidt & Franke 1982;Kleinschmidt et al 1986;Dilworth et al 1987;Dingwall et al 1987;Kleinschmidt & Seiter 1988). Chromatin assembly factor (CAF-I) binds histones and promotes chromatin assembly during DNA replication in vitro (Stillman 1986;Smith & Stillman 1989Kaufman et al 1995).…”

Section: Discussionmentioning

confidence: 99%

NAP‐I is a functional homologue of TAF‐I that is required for replication and transcription of the adenovirus genome in a chromatin‐like structure

et al. 1996

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Background: For the activation of replication and transcription from DNA in a chromatin structure, a variety of factors are thought to be needed that alter the chromatin structure. Template activating factor-I (TAF-I) has been identified as such a host factor required for replication of the adenovirus (Ad) genome complexed with viral basic core proteins (Ad core). TAF-I also stimulates transcription from the Ad core DNA.

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Section: Discussionmentioning

confidence: 99%

NAP‐I is a functional homologue of TAF‐I that is required for replication and transcription of the adenovirus genome in a chromatin‐like structure

et al. 1996

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“…Biochemical fractionation of the crude chromatin assembly extracts led to the discovery of Chromatin Assembly Factor 1 (CAF-1) and Anti-silencing function 1 (Asf1), which both mediate H3/H4 deposition during DNA replication [13,14]. Although both Asf1 and CAF-1 are by themselves histone H3/H4 chaperones, they work jointly together to deposit H3/H4 onto newly-replicated DNA in vitro [13] (Fig.…”

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confidence: 99%

Chromatin disassembly and reassembly during DNA repair

Linger

Tyler

2007

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Current research is demonstrating that the packaging of the eukaryotic genome together with histone proteins into chromatin is playing a fundamental role in DNA repair and the maintenance of genomic integrity. As is well established to be the case for transcription, the chromatin structure dynamically changes during DNA repair. Recent studies indicate that the complete removal of histones from DNA and their subsequent reassembly onto DNA accompanies DNA repair. This review will present evidence indicating that chromatin disassembly and reassembly occur during DNA repair and that these are critical processes for cell survival after DNA repair. Concomitantly, candidate proteins utilized for these processes will be highlighted.

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“…1995;Smith & Stillman 1989). CAF-1 is a histone binding protein complex conserved in various organisms from yeasts to human and higher plants (Kamakaka et al .…”

Section: Introductionmentioning

confidence: 99%

Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis

Ono¹,

Kaya²,

Takeda³

et al. 2006

Genes to Cells

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Newly synthesized DNA is rapidly assembled into mature nucleosomes by the deposition of preexisting and nascent histones, and some parts of this process are facilitated by chromatin assembly factor 1 (CAF-1). Loss-of-function mutants of CAF-1 in Arabidopsis , fasciata ( fas ), show a variety of morphological abnormalities and unique defects in gene expression in the meristems. In order to clarify the implications of CAF-1 in the maintenance of chromatin states in higher eukaryotes, we investigated transcriptional gene silencing (TGS) of various genes in fas mutants. Here, we show that TGS of endogenous CACTA transposons was released in a stochastic manner in fas . Other endogenous silent genes, a transposon AtMu1 and a hypothetical gene T5L23.26 at a heterochromatin knob, were also transcriptionally activated, and the activation of the three different silent loci at different chromosomal sites occurred non-concomitantly with each other. Furthermore, TGS of the silent β β β β -glucuronidase ( GUS ) transgene was also de-repressed randomly in fas . We conclude that CAF-1 ensures the stable inheritance of epigenetic states through growth and development in Arabidopsis .

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Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro

Cited by 656 publications

References 27 publications

NAP‐I is a functional homologue of TAF‐I that is required for replication and transcription of the adenovirus genome in a chromatin‐like structure

NAP‐I is a functional homologue of TAF‐I that is required for replication and transcription of the adenovirus genome in a chromatin‐like structure

Chromatin disassembly and reassembly during DNA repair

Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis

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