Purification process for succinic acid produced by fermentation

Glassner, David A.; Elankovan, Ponnam; Beacom, D.; Berglund, Kris A.

doi:10.1007/bf02933412

Cited by 36 publications

(29 citation statements)

References 7 publications

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“…However, demand for finding a new and cheap bio-based platform chemical to produce GBL has been continuously increased. Therefore, direct hydrogenation of succinic acid is predicted to be one of the economical chemical processes for the production of GBL, because of the increase of succinic acid production in the biorefinery process [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Hydrogenation of Succinic Acid to γ-Butyrolactone over Palladium Catalyst Supported on Mesoporous Alumina Xerogel

et al. 2010

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Mesoporous alumina xerogel (AX) was prepared by a sol-gel method for use as a support for palladium catalyst. Palladium catalyst supported on mesoporous alumina xerogel (Pd/AX) was then prepared by an impregnation method. For comparison, commercial alumina (AC) was also used to prepare Pd/AC catalyst by an impregnation method. Liquid-phase hydrogenation of succinic acid to c-butyrolactone (GBL) was carried out using supported palladium catalysts (Pd/AC and Pd/AX). The supported palladium catalysts (Pd/AC and Pd/AX) were characterized by XRD, BET, HR-TEM, and hydrogen chemisorption analyses. In the hydrogenation of succinic acid to GBL, Pd/AX catalyst showed a better catalytic performance than Pd/AC catalyst. Fine dispersion of palladium of Pd/AX catalyst was responsible for its high catalytic activity.

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Section: Introductionmentioning

confidence: 99%

Hydrogenation of Succinic Acid to γ-Butyrolactone over Palladium Catalyst Supported on Mesoporous Alumina Xerogel

et al. 2010

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“…In the calculations, this maximum thickness is assumed to be 0.001 m, such that the migration distance becomes 0.003 m. The calculation of the migration velocity is explained in our previous article on EIC. 13 Its value becomes 9.5e -5 m/s with a temperature of 35°C and a current density of 50 mA/cm 2 (corresponding to a DF of approximately 10V). Hence, the velocity ratio becomes 26.4, while the multiplication of the maximum migration distance with this ratio yields the maximum height 0.079 m. When the height of the module would be higher than this value, OH -would reach the crystalline layer and dissolve the carboxylic acid crystals.…”

Section: Experimental Results Of Eic With Fumaric Acidmentioning

confidence: 98%

“…Rather complex solutions with elevated temperatures or mixed solvents have been used to overcome this constraint. 13,14 Recently, we proposed the use of crystallization inside the electrodialysis module. Using electrochemically induced crystallization, product removal of slightly soluble carboxylic acids (cinnamic, fumaric, and p-hydroxybenzoic acid) has been demonstrated.…”

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confidence: 99%

Electrochemically Induced Crystallization as a Sustainable Method for Product Recovery of Building Block Chemicals: Techno-Economic Evaluation of Fumaric Acid Separation

Nasrollahnejad

Urbanus

Horst

et al. 2012

Industrial Biotechnology

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Carboxylic acids are key platform chemicals for use as biobased alternatives for fossil-based applications. State-of-the-art fermentations of carboxylic acids at neutral pH with downstream product recovery by pH-shift crystallization are not sustainable due to the accompanied production of waste salts. To earn the label''sustainable,'' salts should be converted into the original base and acid required for fermentation and product recovery. This paper shows that electrochemically induced crystallization (EIC) integrated with fermentation reduces both capital and operating expenditures (CAPEX and OPEX, respectively). EIC is a novel process that utilizes electrolysis of water to induce localized pH-shift crystallization of the carboxylic acid, while neutral bulk conditions are maintained.In the current study, a techno-economic evaluation of the fermentative production of fumaric acid integrated with product removal by crystallization was performed. Three cases were evaluated, two based on classical pH-shift crystallization and one based on fermentation integrated with EIC. The first so-called base case produces a solid waste, while the second employs electrodialysis at the end of downstream processing to regenerate the waste salt and re-use the base and acid. With EIC, electrochemistry obviates the use of chemicals and hence solid waste cannot be formed. Cost estimates for EIC unit operation were based on the mass and energy balances of laboratory-scale experimental work and the resultant conceptual design. Assuming return on investment (ROI) of 15%, the first base case has the lowest required sales price of e2.2/kg fumaric acid (USD2.84/kg fumaric acid). EIC eliminates the necessity of water removal, hence reduces CAPEX and OPEX by 35% and 19%, respectively. Sensitivity analysis reveals that with an augmenting penalty on solid waste disposal (greater than e128/ton; USD164/ ton), EIC is the most economical option. This paper demonstrates that the integration of fermentation with product recovery improves the overall process economics and, by applying EIC, a more sustainable process is obtained.

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“…From the difference of the loading value, the (1,1,1) succinic acid-amine-diluent complex could be predicted in the case of TPA/1-butanol extractant and (1,1), (2,2) complex could predicted in the case of TPA/1-hexanol and TPA/1-octanol. …”

Section: Resultsmentioning

confidence: 98%

“…Anaerobic fermentations offer promise for the production of large quantities of low cost chemicals. A fermentation with high succinic acid yield and concentration have been reported for the anaerobic microorganism [2].…”

Section: Introductionmentioning

confidence: 99%

Reactive extraction of succinic acid with tripropylamine (TPA) in various diluents

Hong

Wang

2000

Bioprocess Engineering

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Succinic acid is of interest as the raw material of polysuccinate which is a biodegradable polymer. The tripropylamine (TPA) was used as the extraction agent for the reactive extraction of succinic acid in various alcohol diluents. Equilibrium and loading data for various active diluents were obtained at various TPA concentrations. At the same TPA concentration the extractabilities of TPA increased as the number of carbon in alcohols decreased. It was explained by decreasing solubility of acid-amine complex due to decreasing polarity with increasing the number of carbon in alcohols. The type of succinic acidamine-diluent complex was predicted by the value of loading with various concentration of TPA/various alcohols.

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Purification process for succinic acid produced by fermentation

Cited by 36 publications

References 7 publications

Hydrogenation of Succinic Acid to γ-Butyrolactone over Palladium Catalyst Supported on Mesoporous Alumina Xerogel

Hydrogenation of Succinic Acid to γ-Butyrolactone over Palladium Catalyst Supported on Mesoporous Alumina Xerogel

Electrochemically Induced Crystallization as a Sustainable Method for Product Recovery of Building Block Chemicals: Techno-Economic Evaluation of Fumaric Acid Separation

Reactive extraction of succinic acid with tripropylamine (TPA) in various diluents

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