Purified Micronized Flavonoid Fraction Ameliorates the Injury of Spleen and Ileum Secondary to Hepatic Ischemia–Reperfusion in Rats

Abstract

The results of this study indicated that MPFF pretreatment significantly limited the injury to the small intestine and spleen induced by hepatic ischemia-reperfusion in rats.

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

“…Reactive oxygen radicals and free radicals are known to cause many pathological disorders [182526]. Therefore, removal of these free radicals from the environment plays an important role in recovery [27]. …”

Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos

“…The anti-inflammatory effect of diosmin and hesperidin is attributed to the suppression of E 2 prostaglandins synthesis and inhibition of adhesive endothelial and leukocyte molecules. These flavonoids also act by ROS scavenging and chelants free iron molecule, confirming its antioxidant effect (8)(9) . The challenge of reducing the toxicity of drugs that have no clinical substitutes has given rise to a large variety of studies to identify procedural or pharmacological solutions.…”

“…Nephrotoxicity mechanism of Amp-B leads to excessive production of ROSs and a reduction of the antioxidant capacity, leading to a predominance of free radicals that encourage lipid peroxidation in cell membrane, proteins and DNA oxidation, characterizing the process of oxidative injury and cell death (6) . Several therapeutic procedures, including drugs with low or no toxicity, are used with the objective of restoring renal blood flow, and reducing inflammation and oxidative stress in the injuries caused by nephrotoxicity (7)(8)(9) . Since the 1930s, the flavonoids diosmin and hesperidin have been used to treat for vascular insufficiency (8) .…”

“…Since the 1930s, the flavonoids diosmin and hesperidin have been used to treat for vascular insufficiency (8) . Diosmin and hesperidin are also recognized for their antioxidant and anti-inflammatory properties (8)(9) . The anti-inflammatory effect of diosmin and hesperidin is attributed to the suppression of E 2 prostaglandins synthesis and inhibition of adhesive endothelial and leukocyte molecules.…”

Efeito protetor da diosmina e hesperidina na nefrotoxidade induzida pela anfotericina B

“…-e OH .-ou induzir a formação de enzimas antioxidantes (22,23) . Estudo em ratos diabéticos demonstrou um alto consumo da reserva antioxidante endógena, como a catalase e SOD no tecido renal e hepático e a elevação de aldeídeos resultantes da peroxidação lipídica.…”