2015
DOI: 10.1113/jp271494
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Purinergic signalling mediates bidirectional crosstalk between chemoreceptor type I and glial‐like type II cells of the rat carotid body

Abstract: Key pointsr Carotid body chemoreceptors are organized in clusters containing receptor type I and contiguous glial-like type II cells.r While type I cells depolarize and release ATP during chemostimulation, the role of type II cells which express purinergic P2Y2 receptors (P2Y2Rs) and ATP-permeable pannexin-1 (Panx-1) channels, is unclear. r We propose that reciprocal crosstalk between type I and type II cells contributes to sensory processing in the carotid body via purinergic signalling pathways. AbstractThe … Show more

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Cited by 42 publications
(86 citation statements)
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References 51 publications
(198 reference statements)
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“…A direct up‐regulation of CD73 activity in the CB in chronic or chronic intermittent hypoxia remains to be confirmed. However, recent studies suggest that ATP and 5‐HT can both augment ATP release from type 2 cells, thereby amplifying the synaptic ATP concentration (Murali & Nurse, ; Murali et al . ).…”
Section: Discussionmentioning
confidence: 99%
“…A direct up‐regulation of CD73 activity in the CB in chronic or chronic intermittent hypoxia remains to be confirmed. However, recent studies suggest that ATP and 5‐HT can both augment ATP release from type 2 cells, thereby amplifying the synaptic ATP concentration (Murali & Nurse, ; Murali et al . ).…”
Section: Discussionmentioning
confidence: 99%
“…It is also possible that hM3Dq is expressed in GFAP + type II cells in the carotid bodies (86,87) and that these cells modulate the activity of type I neurons via bidirectional purinergic signaling (88). Type I neuron depolarization could lead to CNS-mediated chemoreflexes, including hyperventilation, sympathoexcitation and increases in blood pressure (89).…”
Section: Peripheral Versus Central Glial Activation In Sympathetic Acmentioning
confidence: 99%
“…It has been hypothesized that the connexin family of gap junction channels may also play a role in facilitating electrical coupling (Murali et al . ; Nurse, ; Murali & Nurse, ). VGCC, voltage‐gated calcium channel.…”
Section: Introductionmentioning
confidence: 99%
“…ATP released from type I cells during hypoxia or hypercapnia leads to a rise in intracellular Ca 2+ ([Ca 2+ ] i ), followed by a delayed, secondary [Ca 2+ ] i increase in proximal type II cells (Murali et al . ; Murali & Nurse, ). A depolarization of type I cells results in sensory output to the petrosal ganglion and on to the carotid sinus nerve, mediating the cardiorespiratory response in the NTS (Housley et al .…”
Section: Introductionmentioning
confidence: 99%