Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis

Chen, Yu Feng; Shibu, Marthandam Asokan; Fan, Ming; Chen, Ming Cheng; Viswanadha, Vijaya Padma; Yao, Lin; Lai, Chao Hung; Lin, Kuan Ho; Ho, Tsung Jung; Kuo, Wei Wen; Huang, Chih Yang

doi:10.1016/j.jnutbio.2015.12.020

Cited by 60 publications

(44 citation statements)

References 37 publications

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“…In this study, the C57/BL6 mice showed increase in the IGF‐1R survival mechanism as a compensative protective mechanism against HFD and andrographolide treatment further upregulated the IGF‐1R survival mechanism and fortified the cardio‐protection in obese mice (Figure ). Furthermore, our previous studies on obesity and diabetes in Zuker rats, SD rats, C57/BL6 mice and in hamsters showed a common set of changes in cardiac tissue morphology such as cardiac tissue disarray, increased interstitial space, and minor cardiac fibrosis, and further displayed significantly increased protein levels of Fas ligand, Fas death receptors, and FADD . In this study, HFD feeding in C57/BL6 mice triggered increase in the number of TUNEL‐positive apoptotic cells in heart and further caused minor cardiac fibrosis.…”

Section: Discussionsupporting

confidence: 58%

“…In addition, mitochondrial‐dependent intrinsic cardiac apoptosis is also observed in obese condition . Interruption of apoptosis is understood to be one of the possible strategies to reverse or attenuate cardiac disorders and in this regard, several alternative approaches are considered for their anti‐apoptotic benefits against obesity, DM and other pathological conditions . Andrographis paniculata (Burm.…”

Section: Introductionmentioning

confidence: 99%

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Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Lin

Shibu

Kuo

et al. 2020

Environmental Toxicology

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Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD-induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac-damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro-apoptotic proteins and decrease in the proteins of IGF-1R-survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Lin

Shibu

Kuo

et al. 2020

Environmental Toxicology

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“…These findings are consistent with Baş, Kalender, and Apaydın (2014). Cong et al (2015) and Chen et al (2016) who find eosinophilia in myocardial fibers and edema in connective tissue. Also, chemicals can cause histopathological changes in tissues, such as: liver (Bas, Pandır, & Kalender, 2016), kidneys (Pandir et al, 2016), and testes (Kara, Baş, & Pandır, 2016).…”

Section: Stz-caused Dm Induces Oxidative Stress and Then Hyperglycemimentioning

confidence: 99%

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Saracoğlu¹,

Baş

Pandır

2018

J Food Biochem

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The objective of this current study is to search the impacts of furan and lycopene on a diabetic rat's heart. Diabetes increases prevalence with a sedentary lifestyle and obesity. Furan, a carcinogen, was detected in foods that had undergone thermal treatment. Two groups were formed, such as: the control and diabetic groups. Diabetic groups fall into four allocated groups: control, lycopene, furan, and furan + lycopene. The changes in malondialdehide levels, antioxidant enzymes’ activities, and histopathology of the heart were pointed out. We observed that the changes in both the MDA level and the antioxidant enzymes’ activities were due to diabetes. Furan‐induced increment in MDA levels, but GST, CAT, SOD, and GPx activities showed a decrease. Lycopene influenced these changes positively. In terms of the pathological studies, changes were also observed in diabetic rats. The histological damage in the diabetic furan groups was found to be very serious. Lycopene was protective against furan that caused histopathological changes. Diabetes and furan resulted into heart damages in rats and lycopene showed preventive effects. But this was not a complete protection. Practical applications Furan by product of chlorinated chemical compounds production and chemical processes including combustion, are virtually ubiquitous in the environment. Because of this, furan occur potential risk for human health. Furan is known to exist at higher levels in fatty foods, such as full‐fat milk and dairy products, meat and eggs. They can accumulate in the fatty tissues of animals and humans. Diabetes increase in the prevalence of a sedentary lifestyle and obesity. Diabetes with furan‐induced cardiotoxicity. Foods should not be heated over and over again, especially diabetic heart patients should stay away from this situation.

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“…Ellagitannins have been shown in cell culture and animal models of chronic inflammatory diseases to reduce proinflammatory prostaglandins (53), cytokines (45, 54), and other proteins (42, 55, 56). Anthocyanins have also been shown to inhibit proinflammatory proteins (57, 58), and activate anti-inflammatory pathways in models of inflammation (59–63). It is possible that the combination of the different polyphenols in the BerriQi ® Boysenberry and apple juice concentrate act on a number of different immune pathways to regulate the immune responses to OVA.…”

Section: Discussionmentioning

confidence: 99%

Boysenberry and apple juice concentrate reduces acute lung inflammation through increased alternatively activated macrophage activity in an acute mouse model of allergic airways disease

Shaw

Hurst

Cooney

et al. 2020

Preprint

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Bioactive compounds such as anthocyanins, proanthocyanins and other polyphenols are found in a wide variety of fruits and vegetables, and consumption of these have been associated with reduced lung inflammation and improved lung function in asthma and other lung diseases. We investigated whether a combination of Boysenberry and apple juice, found in BerriQi® Boysenberry and apple juice concentrate, could reduce the allergic airways inflammation associated with asthma. We characterised the polyphenolic components in BerriQi® Boysenberry and apple juice concentrate and identified the main compounds as cyanidin glycosides, ellagitannins, and chlorogenic acid. We found that consumption of 2.5 mg/kg of total anthocyanins from the BerriQi® Boysenberry and apple juice concentrate significantly reduced eosinophil infiltration following acute ovalbumin (OVA) exposure in a mouse model of allergic airways inflammation. We found that BerriQi® Boysenberry and apple juice concentrate consumption increased M2 (CD206+) macrophages and the production of the M2-associated cytokines CXCL10 and CCL4 within the lung. These results suggest that consumption of BerriQi® Boysenberry and apple juice concentrate promotes a shift towards an anti-inflammatory environment within the lung leading to reduced immune cell infiltration and tissue damage.

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Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis

Cited by 60 publications

References 37 publications

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Boysenberry and apple juice concentrate reduces acute lung inflammation through increased alternatively activated macrophage activity in an acute mouse model of allergic airways disease

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