Pustular irritant contact dermatitis caused by dexpanthenol in a child

Abstract

Pustular irritant contact dermatitis is rare and unusual clinic form of contact dermatitis. Dexpanthenol is the stable alcoholic analogue of pantothenic acid. It is widely used in cosmetics and topical medical products for several purposes. We present the case of 8-year-old girl with pustules over erythematous and eczematous areas on the face and neck. To the best of our knowledge, this is the first case reported that is diagnosed as pustular irritant contact dermatitis caused by dexpanthenol.

Allergic contact dermatitis caused by dexpanthenol confirmed with open application test: A case report

“…10 Unusual clinical presentation of panthenol-caused dermatitis is pustular form, where pustules all over erythematous and eczematous bases can be described. 11 Phases in ACD often take turns, from latency to dermatitis, especially if patients use anti-inflammatory therapy. This means that patients' history of dermatitis are long, years or decades, where intermittent pruritic patches on face, trunk or extremities are often treated symptomatically.…”

Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

“…between 1990 and 2016, amounting to 0.7%, a frequency that is very similar to that in our study (0.89%). Two cases of ACD caused by dexpanthenol were reported in children, but all age groups seem to be affected, as in our study, with the age of cases ranging from 15 to 75 years. There is also one report of a severe systemic reaction induced by dexpanthenol in multivitamin tablets after previous use of a sunscreen cream containing dexpanthenol …”

“…Dexpanthenol is widely used in the pharmaceutical and cosmetic industries for its moisturizing and soothing properties . It improves epidermal barrier disruption, reducing transepidermal water loss and improving hydration of the stratum corneum, accelerates skin re‐epithelialization, and activates fibroblast proliferation; it is therefore used as a wound‐healing promoter for ulcers, bed sores, excoriations, burns, and sunburn . Dexpanthenol is also included in topical drugs for rhinitis and conjunctivitis …”

Oleylamine‐induced pustular irritant contact dermatitis

“…It is mainly used as a surfactant or precursor to surfactants and is known to be cytotoxic and to cause skin corrosion . Pustular contact dermatitis is a rare form of contact dermatitis, with merbromin, fluorine, dexpanthenol, croton oil, and minoxidil being reported as likely causes . However, to the best of our knowledge, there is no report of pustular contact dermatitis induced by oleylamine exposure in the literature.…”

“…1 Pustular contact dermatitis is a rare form of contact dermatitis, with merbromin, fluorine, dexpanthenol, croton oil, and minoxidil being reported as likely causes. [2][3][4][5] However, to the F I G U R E 1 Multiple, 0.3-0.5-cmsized, yellowish pustules on the face and neck (A,B: initial; C,D: 1 month later) best of our knowledge, there is no report of pustular contact dermatitis induced by oleylamine exposure in the literature.…”