Putative antioxidant property of sesame oil in an oxidative stress model of myocardial injury

Abstract

a b s t r a c tBackground: Sesame oil is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the antioxidant property of chronic oral administration of sesame oil against isoproterenol induced myocardial injury. Methods and results: Male Wistar albino rats were randomly divided into five groups (n ¼ 6) and treated as per treatment protocol with two different doses of sesame oil (5 and 10 ml/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group ISO) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Sesame oil in both the dose (group S1 and S2) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and Catalase). Sesame oil also increased the lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate transaminase (AST) as a myocardial marker enzyme in heart homogenate. As histologically evident isoproterenol induced myocardial injury was well preserved by the chronic administration of sesame oil. The protective role of sesame oil was compared with the reference standard a-tocopherol (group S3) also showing the similar effect. Conclusion: From this finding it has been concluded that chronic administration of sesame oil offers cardio protective action via putative antioxidant property.

Effects of endomorphin-1 postconditioning on myocardial ischemia/reperfusion injury and myocardial cell apoptosis in a rat model

“…Hemodynamic indexes, myocardial enzymes and myocardial infarct size all reflect the degree of I/R damage. Previous studies have demonstrated that the primary mechanisms underlying MIRI may include excessive production of free radicals, infiltration of inflammatory cells, mitochondrial dysfunction and apoptosis of myocardial cells (19,(23)(24)(25). Therefore, reducing the generation of free radicals (26), inhibiting the inflammatory response and suppressing apoptosis (27) may markedly reduce I/R injury.…”

Enduring amnesia induced by ICV scopolamine is reversed by sesame oil in male rats

“…Sesame oil is a strong antioxidant dietary source for human 11 . Previous studies have shown that sesame oil has improving effects on memory and learning.…”

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

“…Hsu & Liu, reported that the level of lipid peroxidation, hydroxyl radical, and nitrite levels reduced, whereas the antioxidant enzyme SOD and CAT increased in SO‐treated LPS‐induced oxidative stress rat models (Hsu, Chiang et al, ). In addition, parenterally SO‐treated animal groups showed attenuation of hepatic disorder, although the symptoms were different when the SO was given orally (Ahmad et al, ; Hsu & Liu, ; Saleem, Chetty, & Kavimani, ). However, superoxide anion decreased and GSH increased in the oral SO groups (Ahmad et al, ; Saleem et al, ).…”

“…In addition, parenterally SO‐treated animal groups showed attenuation of hepatic disorder, although the symptoms were different when the SO was given orally (Ahmad et al, ; Hsu & Liu, ; Saleem, Chetty, & Kavimani, ). However, superoxide anion decreased and GSH increased in the oral SO groups (Ahmad et al, ; Saleem et al, ). Ahmad et al () showing that dietary SO behaves as an antioxidant, resulting in increased enzymatic and nonenzymatic antioxidants activity in the middle cerebral artery occlusion (MCAO rat model against MCAO‐induced cerebral ischemia injury (Ahmad et al, ).…”