PVA hydrogel properties for biomedical application

Jiang, Shan; Liu, Sha; Feng, Wenhao

doi:10.1016/j.jmbbm.2011.04.005

Cited by 448 publications

(215 citation statements)

References 18 publications

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“…For both cases a degree of gelling of the discs during dissolution can be seen in Figure 11a and b. The gelation of CMV discs can be attributed to the hydrogel formation ability of PVA reported in literature [37,38]. The discs in pH 1.2 HCl show significant softening that led to the folding of the wetted discs (which appears as reduction in size), whereas there was no change in size of the discs tested in pH 6.8 PBS.…”

Section: In Vitro Disintegration and Drug Release Study Of Fdm Printementioning

confidence: 54%

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

Alhijjaj

Belton

2016

European Journal of Pharmaceutics and Biopharmaceutics

235

134

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FDM 3D printing has been recently attracted increasing research efforts towards the production of personalized solid oral formulations. However, commercially available FDM printers are extremely limited with regards to the materials that can be processed to few types of thermoplastic polymers, which often may not be pharmaceutically approved materials nor ideal for optimizing dosage form performance of poor soluble compounds. This study explored the use of polymer blends as a formulation strategy to overcome this processability issue and to provide adjustable drug release rates from the printed dispersions. Solid dispersions of felodipine, the model drug, were successfully fabricated using FDM 3D printing with polymer blends of PEG, PEO and Tween 80 with either Eudragit E PO or Soluplus. As PVA is one of most widely used polymers in FDM 3D printing, a PVA based solid dispersion was used as a benchmark to compare the polymer blend systems to in terms processability. The polymer blends exhibited excellent printability and were suitable for processing using a commercially available FDM 3D printer. With 10% drug loading, all characterization data indicated that the model drug was molecularly dispersed in the matrices.During in vitro dissolution testing, it was clear that the disintegration behavior of the formulations significantly influenced the rates of drug release. Eudragit EPO based blend dispersions showed bulk disintegration; whereas the Soluplus based blends showed the 'peeling' style disintegration of strip-by-strip. The results indicated that interplay of the miscibility between excipients in the blends, the solubility of the materials in the dissolution media and the degree of fusion between the printed strips during FDM process can be used to manipulate the drug release rate of the dispersions. This brings new insight into the design principles of controlled release formulations using FDM 3D printing.

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Section: In Vitro Disintegration and Drug Release Study Of Fdm Printementioning

confidence: 54%

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

Alhijjaj

Belton

2016

European Journal of Pharmaceutics and Biopharmaceutics

235

134

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“…It has been demonstrated that when PVA concentration is 8g/dl with a mix water/NaCl/ DMSO solvent, prepared with 7 freeze/thaw cycles, the material has similar biomechanical characterizations and morphological structure with porcine liver (Jiang and Liu 2011). The force profile acquired from linearly penetration into porcine liver and PVA hydrogel was shown in Fig.…”

Section: Experimental Materialsmentioning

confidence: 93%

Experimental study of needle–tissue interaction forces: Effect of needle geometries, insertion methods and tissue characteristics

Jiang¹,

Li²,

Yan³

et al. 2014

Journal of Biomechanics

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120

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“…15 In tissue engineering, PVAbased scaffolds have been widely studied in order to substitute the currently available artificial grafts used for cultivation of living cells, as they possess a porous structure which enables their degradation. 2,16 One of the recent applications of PVA-based materials is in sponge devices which are constructed of soft, absorbent and highly retentive polyvinyl alcohol foam with controlled porosity that makes them a good candidate for a variety of applications, including ophthalmic procedures, refractive surgeries, wound healing and tissue engineering. Unlike other materials, PVA sponges are made of inert and non-biodegradable materials and yet are soft enough to be sectioned for histological analysis.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Fabrication and mechanical characterization of a polyvinyl alcohol sponge for tissue engineering applications

2013

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Polyvinyl alcohol (PVA) sponges are widely used for clinical applications, including ophthalmic surgical treatments, wound healing and tissue engineering. There is, however, a lack of sufficient data on the mechanical properties of PVA sponges. In this study, a biomechanical method is used to characterize the elastic modulus, maximum stress and strain as well as the swelling ratio of a fabricated PVA sponge (P-sponge) and it is compared with two commercially available PVA sponges (CENEFOM and EYETEC). The results indicate that the elastic modulus of the P-sponge is 5.32% and 13.45% lower than that of the CENEFOM and EYETEC sponges, while it bears 4.11% more and 10.37% less stress compared to the CENEFOM and EYETEC sponges, respectively. The P-sponge shows a maximum strain of 32% more than the EYETEC sponge as well as a 26.78% higher swelling ratio, which is a significantly higher absorbency compared to the CENEFOM. It is believed that the results of this study would help for a better understanding of the extension, rupture and swelling mechanism of PVA sponges, which could lead to crucial improvement in the design and application of PVAbased materials in ophthalmic and plastic surgeries as well as wound healing and tissue engineering.

show abstract

PVA hydrogel properties for biomedical application

Cited by 448 publications

References 18 publications

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

Experimental study of needle–tissue interaction forces: Effect of needle geometries, insertion methods and tissue characteristics

RETRACTED: Fabrication and mechanical characterization of a polyvinyl alcohol sponge for tissue engineering applications

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