Pycnogenol, French Maritime Pine Bark Extract, Augments Endothelium-Dependent Vasodilation in Humans

Nishioka, Kenji; Hidaka, Takayuki; Nakamura, Shuji; Umemura, Takashi; Jitsuiki, Daisuke; Soga, Junko; Goto, Chikara; Chayama, Kazuaki; Yoshizumi, Masao; Higashi, Yukihito

doi:10.1291/hypres.30.775

Cited by 70 publications

(83 citation statements)

References 26 publications

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“…Pharmacologic studies have demonstrated that Mirtoselect counteracts the hyperpermeability of ciliary capillaries, initiated by paracentesis, as measured by the Evans Blue concentration in the aqueous humor. 7,14 Pycnogenol was shown to improve endothelial function 6 and to lower blood pressure in asymptomatic hypertension. 15 The improved ocular blood flow shown in this study supports the assumption that the dietary supplement may exert an action on lowering IOP by decreasing humor inflow.…”

Section: Discussionmentioning

confidence: 99%

“…Mirtogenol tablets further contain 40 mg French maritime pine bark extract, Pycnogenol (Horphag Research, London, UK), 9 which consists of flavan-3-ols standardized to 70% ± 5% procyanidins with conformance to the USP 31 on "Maritime Pine Extract". 6,7 Xalatan ® (Pharmacia, Pfizer) was taken one drop per eye daily, equivalent to 1.5 µg latanoprost, in the evening.…”

Section: Methodsmentioning

confidence: 99%

“…5 Pycnogenol was shown in human pharmacologic studies to improve endothelial function. 6 Mirtoselect was shown to counteract hyperpermeability of ciliary capillaries, initiated by paracentesis, as measured by the Evans Blue concentration in the aqueous humor. 7 The initial study on Mirtogenol suggested a significantly increased ocular blood flow and this effect was suggested to be predominantly responsible for the decreased IOP.…”

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Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Steigerwalt

Belcaro²,

Paolo³

et al. 2010

OPTH

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Purpose:The dietary supplement Mirtogenol ® was previously shown to lower elevated intraocular pressure (IOP). We here present the effects of this supplement on IOP in comparison as well as in combination with latanoprost eye drops. Methods: Seventy-nine patients with asymptomatic ocular hypertension were randomly assigned to three groups receiving either the supplement, or latanoprost eye drops, or both in combination. Intraocular pressure and retinal blood flow were investigated in monthly intervals over 24 weeks.Results: Mirtogenol alone lowered IOP from baseline 38.1 to 29.0 mmHg after 16 weeks, with little further improvement during the following eight weeks. Latanoprost rapidly lowered IOP from baseline 37.7 to 27.2 mmHg within four weeks, without further effects thereafter. The combination of the supplement and latanoprost lowered IOP from 38.0 to 27.3 mmHg after four weeks, and further decreased IOP to 24.2 mmHg after six weeks. After 24 weeks IOP with the combination treatment (23.0 mmHg) was significantly lower than with latanoprost alone (27.2 mmHg). Mirtogenol and latanoprost individually showed comparable effects for gradually increasing central artery blood flow with treatment duration. Combination treatment showed higher systolic blood flow velocity throughout the trial period. The diastolic blood flow velocity gradually increased with treatment duration in all three groups. From twelve weeks onwards, the diastolic component with combination treatment was higher than with individual treatments. Conclusions: Mirtogenol lowered elevated IOP in patients almost as effectively as latanoprost, however, it takes much longer (24 vs 4 weeks). The combination of both was more effective for lowering IOP and the combination yielded better retinal blood flow. No serious side effects occurred during the study, apart from standard side effects in patients related to Latanoprost. These promising results warrant further research of Mirtogenol with a larger patient group.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Steigerwalt

Belcaro²,

Paolo³

et al. 2010

OPTH

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“…Also, antioxidant effects have been described for extracts from Pinus maritime bark (Pycnogenol®) (Packer et al 1999) and from Pinus pinaster (Jerez et al 2007a) under diverse extraction conditions. Barks extract is a natural resource that could replace synthetic antioxidants as butylatedhydroxyanisole (BHA) and butylatedhydroxytoluene (BHT), which are suspected of being responsible for liver damage and carcinogenesis in laboratory animals (Nishioka et al 2007).…”

Section: Universidad Del Bío -Bíomentioning

confidence: 99%

Comparison of phenolic extracts obtained of Pinus radiata bark from pulp and paper industry and sawmill industry

Aspé¹,

Fernández²

2011

Maderas, Cienc. tecnol.

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Pinus radiata barks obtained from tress of different ages, as subproduct of pulp and paper (trees less than 10 years) and sawmill (trees between 20 to 25 years) industries, were used to produce extracts containing phenolic compounds. A factorial design 2 3 was used to evaluate the influence of the variables temperature (25 -35 ºC), solvent type (acetone -ethanol) and extraction time (1-12 h). The extracts were compared in their extraction yield (%), total phenols (by FolinCiocalteau), and radical scavenging activity (by DPPH). The extract obtained from old trunks presented a higher extraction yield than from young trees. The highest yield value was 2.56%, which was obtained using acetone as solvent for 12 h and 35°C. The highest concentration of phenol (5.84±0.18 g CE g extract -1 ), and scavenging activity (IP=86.1±4.4%) were also obtained for this type of extract. The extraction duration was the variable that most influenced the parameters studied. The bark's radical scavenging power was greater than BHT (40%) and slightly lower than ascorbic acid (92%), common commercial antioxidants.

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“…Pycnogenol ® , a trademark of Horphag Research, is a standardized extract of French maritime pine bark (Rohdewald, 2002;2005). Pycnogenol ® improves endothelial function and has important anti-infl ammatory, antithrombotic and venotropic properties which may be benefi cial in patients with hemorrhoids both for acute and for chronic treatment, preventing new attacks (Blazsó et al, 2004;Belcaro et al, 2005;Cesarone et al, 2006a;Nishioka et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Pycnogenol^® treatment of acute hemorrhoidal episodes

Belcaro

Cesarone

Errichi

et al. 2009

Phytotherapy Research

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We investigated the efficacy of orally and topically applied Pycnogenol for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol in addition to oral Pycnogenol the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol eases the management of acute hemorrhoidal attacks and help avoid bleedings.

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Pycnogenol, French Maritime Pine Bark Extract, Augments Endothelium-Dependent Vasodilation in Humans

Cited by 70 publications

References 26 publications

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Comparison of phenolic extracts obtained of Pinus radiata bark from pulp and paper industry and sawmill industry

Pycnogenol^® treatment of acute hemorrhoidal episodes

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Pycnogenol, French Maritime Pine Bark Extract, Augments Endothelium-Dependent Vasodilation in Humans

Cited by 70 publications

References 26 publications

Mirtogenol&reg; potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Mirtogenol&reg; potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Comparison of phenolic extracts obtained of Pinus radiata bark from pulp and paper industry and sawmill industry

Pycnogenol® treatment of acute hemorrhoidal episodes

Contact Info

Product

Resources

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Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

Pycnogenol^® treatment of acute hemorrhoidal episodes