Pyloric stenosis presenting with halitosis.

Tydd, T.; Dyer, N. H.

doi:10.1136/bmj.3.5926.321

Cited by 12 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-oral pathological halitosis can originate from the upper respiratory tract and from other sources that are carried by blood and exhaled in the lung (Delanghe et al, 1997;Tangerman &Winkel, 2007). Gastrointestinal diseases are also generally believed to cause halitosis (Adler et al, 2005;Tydd & Dyer, 1974). In this study, oral H. pylori DNA was detected in the saliva of subjects complaining of halitosis and the relationships between oral H. pylori infection and oral health and malodour were examined.…”

mentioning

confidence: 99%

Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis

Suzuki

Yoneda

Naito

et al. 2008

Journal of Medical Microbiology

View full text Add to dashboard Cite

Helicobacter pylori infection, which causes peptic ulcers and gastric cancer, is considered a possible cause of halitosis. Recently, the oral cavity was identified as a possible H. pylori reservoir, particularly in the presence of periodontal disease, which is a cause of halitosis. The purpose of this study was to evaluate by PCR the prevalence of oral H. pylori in the saliva of subjects complaining of halitosis. Samples were obtained from 326 non-dyspeptic subjects, comprising 251 subjects with actual malodour and 75 subjects without halitosis. DNA was extracted from the samples, and the presence of H. pylori and periodontopathic bacteria including Porphyromonas gingivalis, Treponema denticola and Prevotella intermedia was examined by PCR. H. pylori was detected in 21 (6.4 %) of 326 samples. The methyl mercaptan concentration and periodontal parameters including tooth mobility, periodontal pocket depth (PPD) and occult blood in the saliva were significantly greater in the H. pylori-positive subjects. Each of the periodontopathic bacteria was also detected at a significantly higher frequency in the H. pylori-positive subjects. Among those patients with a PPD of ¢5 mm and a tongue coating score of ¡2, no difference was observed in oral malodour levels between the H. pylori-positive and -negative subjects. However, the presence of occult blood in the saliva and the prevalence of Prevotella intermedia were significantly greater in the H. pylori-positive subjects. H. pylori was detected in 16 (15.7 %) of 102 subjects with periodontitis, suggesting that progression of periodontal pocket and inflammation may favour colonization by this species and that H. pylori infection may be indirectly associated with oral pathological halitosis following periodontitis. INTRODUCTIONHelicobacter pylori is a spiral, microaerophilic, Gramnegative bacterium that colonizes the human gastrointestinal tract, primarily the stomach (Covacci et al., 1999). It is also believed to be responsible for gastritis and peptic ulcers, and is a risk factor for gastric cancer (Dunn et al., 1992; Parsonnet et al., 1991;Warren & Marshall, 1983); however, the mode of transmission of H. pylori is poorly understood. Several studies have detected H. pylori in the human oral cavity, particularly in patients with gingivitis or chronic periodontitis (Anand et al., 2006; Gebara et al., 2006;Souto & Colombo, 2008), and have thus suggested that the oral cavity is the primary extragastric reservoir for H. pylori. In contrast, other studies have failed to find evidence supporting the role of the oral cavity as a major reservoir of H. pylori (Czesnikiewicz-Guzik et al., 2004;Loster et al., 2006).Halitosis is a common problem in humans, and oral malodour is largely caused by periodontitis, tongue debris, poor oral hygiene, deep caries, inadequately fitted restorations and endodontic lesions (Rosenberg et al., 1991;Tonzetich, 1977;Yoneda et al., 2006); specifically, it is primarily the result of the microbial metabolism of amino acids in local debris (Scully et al.,...

show abstract

mentioning

confidence: 99%

Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis

Suzuki

Yoneda

Naito

et al. 2008

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Obstruction of the gastric tract in infants, such as congenital pyloric stenosis, causes halitosis because of the vomited food or gastric juice 18 . Acquired pyloric stenosis is caused by tumours, scars from gastric or duodenal ulcers, as well as other mechanisms. It has been described that the malodour resulting from this condition smells like rotten eggs, and it has been reported that CO?, H 2 , CH 4 , and air were found in the gas from the stomach 7 • Foul odour caused by pyloric stenosis was improved with gastric lavage 7 , and a tetracycline regimen improved halitosis 8 A few cases of extrinsic duodenal obstruction with halitosis were reported 19 . The peritoneal bands pass across from the colon to the duodenum, gallbladder, liver, and kidney.…”

Section: Halitosis and Gastrointestinal Diseasesmentioning

confidence: 99%

Gastrointestinal diseases and halitosis: association of gastric Helicobacter pyloriinfection

Hoshi¹,

Yamano²,

Mitsunaga³

et al. 2002

International Dental Journal

View full text Add to dashboard Cite

The relationship between gastrointestinal conditions and halitosis is discussed. Few reports have suggested that gastrointestinal diseases may cause halitosis. H. pylori infection, which causes gastric ulcers, is considered as a possible cause for halitosis. Intensity of malodour of mouth air was found to be higher in H. pylori-positive patients than in negative patients. The levels of hydrogen sulphide and dimethyl sulphide in mouth air were also significantly higher in the positive patients than in the negative patients (P<0.05). When odour strength in exhaled breath was compared between the two groups, no significant difference was found. Hence, H. pylori infection might not cause a systemic condition producing breath odour. Although there were no significant differences in periodontal parameters or tongue coating between the positive and negative groups, H. pylori may be a frequent contributor to the production of malodour even though its role had not been suspected before. Further study would be necessary to clarify the reason for the increase of volatile sulphur compounds (VSCs) level in H. pylori infection.

show abstract

“…Volatile sulfur compounds (VSC; hydrogen sulfide, methyl mercaptan, and dimethyl sulfide) are identified to be the principal etiological agents. Additionally, gastrointestinal diseases are generally believed to cause halitosis 4–6 . A peculiar breath has often been noted in patients with diabetes, liver diseases, renal diseases, and malignancies 7,8 …”

Section: Introductionmentioning

confidence: 99%

“…Additionally, gastrointestinal diseases are generally believed to cause halitosis. [4][5][6] A peculiar breath has often been noted in patients with diabetes, liver diseases, renal diseases, and malignancies. 7,8 Helicobacter pylori infection is a definite cause of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Changes in halitosis value before and after Helicobacter pylori eradication: A single‐institutional prospective study

Kudo

Miyachi

et al. 2022

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim Although patients report either improved or worsened halitosis after Helicobacter pylori eradication therapy, such complaints are subjective. Only a few studies have objectively evaluated reports of changes in halitosis after H. pylori eradication; thus, this study aimed to investigate these changes after a successful H. pylori eradication. Methods Between February 2015 and October 2018, 56 347 patients visited the clinic. Informed consent for participation in this study was obtained from 164 patients scheduled to undergo upper gastrointestinal endoscopy due to halitosis. Of the 91 patients with H. pylori infection, the halitosis values were evaluated as Refres breath (RB) values using a Total Gas Detector™ System and compared before and after successful H. pylori eradication, as confirmed with urea breath testing. Results Among the 91 patients treated, 77 patients were successfully eradicated of H. pylori and had their Refres values measured (21 men and 56 women; mean age, 64.2 ± 11.5 years, including 10 smokers); among these 77 patients, 27 showed RB values of > 60. Their RB values significantly improved from 73.5 Â (95% confidence interval [CI], 64.1–82.9) to 59.4 Â (95% CI, 50.0–68.8) (P = 0.038). Of the 30 patients who could be followed up for > 2 years after successful H. pylori eradication, 8 with an RB value ≥ 60 showed significant RB value improvements from 77.9 Â (95% CI, 59.4–96.4) to 30.1 Â (95% CI, 11.6–48.6) (P = 0.0016). Conclusions Helicobacter pylori eradication therapy could improve halitosis, and such improvement could be maintained even 2 years after successful eradication.

show abstract

Pyloric stenosis presenting with halitosis.

Cited by 12 publications

References 1 publication

Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis

Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis

Gastrointestinal diseases and halitosis: association of gastric Helicobacter pyloriinfection

Changes in halitosis value before and after Helicobacter pylori eradication: A single‐institutional prospective study

Contact Info

Product

Resources

About