Pyramidal Effects on Lumbo‐Sacral Internewones Activated by Somatic Afferents

Lundberg, Arne; Norrsell, Ulf; Voorhoeve, P. E.

doi:10.1111/j.1748-1716.1962.tb02498.x

Cited by 181 publications

(32 citation statements)

References 13 publications

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“…The pyramidal effects on interneurones were studied by and Lundberg, Norrsell & Voorhoeve (1962). They found that electrical stimulation of the post cruciate cortex facilitated the segmental interneurones.…”

Section: Discussionmentioning

confidence: 99%

Projection to cerebral cortex of Group I muscle afferents from the cat's hind limb

Landgren¹,

Silfvenius²

1969

The Journal of Physiology

135

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SUMMARY1. Muscle afferent projections from the contralateral hind limb to the postsigmoid gyrus of the cerebral cortex were investigated in cats anaesthetized with chloralose. The evoked potentials were recorded from the cortical surface or from deeper layers by penetrating micro-electrodes. Graded electrical stimulation of the nerves was used.2. Group Ia as well as Ib muscle afferents from the contralateral quadriceps, posterior biceps-semitendinosus, gastrocnemius-soleus and deep peroneal muscles projected to two different loci in the postsigmoid gyrus. One of these was located on the dorsal surface of the hemisphere 4-5 mm lateral to the mid line and 1-3 mm posterior to the cruciate sulcus, thus rostro-miedial to the postcruciate dimple. The other was located on the medial surface of the hemisphere adjacent to the cruciate sulcus. There was no overlap between the two loci.3. There was no significant difference in thresholds or latencies of the Group I responses in the two loci. The latency was short and similar to that of the potential evoked by the cutaneous afferents in the somatosensory primary projection areas.4. The Group lb path was largely independent of the Ia path, because a maximal Group I volley evoked a response, when the Ia path was made refractory by simultaneous stimulation with a maximal I a volley at 20 per second.5. The cortical potentials evoked by the Group I muscle afferents from the contralateral hind limb did not change after transection of the dorsal columns at C 1-C 3 levels but disappeared after a superficial section in the dorsolateral fascicle at C 1 level. The responses were not affected by cerebellectomy. It was concluided that the path travelled with the dorsal spinocerebellar tract or utilized brain stem collaterals of this tract.6. Group II muscle afferents evoked a response near the border of the S. LANDGREN AND H. SILFVENI US Group I loci, but not in the positions where the Group I responses were maximal in amplitude.7. The receptor origin of the stimulated Group I afferents, the location of the medullary relay in the Group I path and the destination of the efferent outflow from the Group I loci were discussed.

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Section: Discussionmentioning

confidence: 99%

Projection to cerebral cortex of Group I muscle afferents from the cat's hind limb

Landgren¹,

Silfvenius²

1969

The Journal of Physiology

135

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“…For example, the rubrospinal and corticospinal tracts facilitate FRA pathways (Hongo et al, 1969(Hongo et al, , 1972Hultborn et al, 1976;Jankowska et al, 1976;Lundberg and Vooehoeve, 1962) so that these tracts can produce fine movements (see Jankowska, 1992). Signals from the midbrain locomotor region also excite group II interneurons (Edgley et al, 1988;Schefchyk et al, 1990) and induce rhythmic firing of reciprocal Ia interneurons (Carol and Jordan, 1987;Feldman and Orlovsky, 1975) and…”

Section: (3) Interaction Between the Reticulospinal System And Fra Symentioning

confidence: 99%

Medullary reticulospinal tract mediating a generalized motor inhibition in cats: iii. functional organization of spinal interneurons in the lower lumbar segments

2003

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“…Activity in the latter two pathways facilitates transmission in reflex paths to motoneurones and primary afferents by giving excitatory action to their interneurones Lundberg, Norrsell & Voorhoeve, 1962;Hongo, Jankowska & Lundberg, 1965;Lundberg, 1964Lundberg, , 1967. However, in many interneurones IPSPs are evoked from the two pathways, in fact much more frequently than from the dorsal reticulospinal system.…”

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confidence: 99%

Reticulospinal inhibition of interneurones

Engberg¹,

Lundberg²,

Ryall³

1968

The Journal of Physiology

Self Cite

136

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SUMMARY1. The effect of electrical stimulation of the brain stem on interneurones in the dorsal horn and intermediary region has been investigated in decerebrate cats after partial transection of the spinal cord.2. Stimuli that effectively depress reflex transmission without giving a primary afferent depolarization inhibit the discharge evoked from the flexor reflex afferents in interneurones.3. Brain stem stimulation did not give post-synaptic potentials in the great majority of interneurones but effectively depressed the excitatory post-synaptic potentials (EPSPs) and inhibitory post-synaptic potentials (IPSPs) evoked from the flexor reflex afferents in these interneurones.4. IPSPs were, however, evoked in five of seventy-eight intracellularly recorded interneurones. These five interneurones were monosynaptically activated from primary afferents.5. It is tentatively postulated that a dorsal reticulospinal system inhibits reflex transmission by giving post-synaptic inhibition in first order interneurones. The results are also discussed in relation to effects on interneurones from other descending pathways.

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Pyramidal Effects on Lumbo‐Sacral Internewones Activated by Somatic Afferents

Cited by 181 publications

References 13 publications

Projection to cerebral cortex of Group I muscle afferents from the cat's hind limb

Projection to cerebral cortex of Group I muscle afferents from the cat's hind limb

Medullary reticulospinal tract mediating a generalized motor inhibition in cats: iii. functional organization of spinal interneurons in the lower lumbar segments

Reticulospinal inhibition of interneurones

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