Pyranocoumarin derivatives from Seseli tortuosum

Minor Furanocoumarins and Coumarins in Grapefruit Peel Oil as Inhibitors of Human Cytochrome P450 3A4

“…The proton resonance of H-4 (δ 8.17) confirms the 5-O substitution. 19 Also similar to 1, the 13 C and 1 H NMR data are consistent with the absence of H-7′ and with the involvement of C-6′ and C-7′ in the acetal portion of 5. The neutral loss of 146 amu in the ESIMS spectrum is consistent with the loss of 1-octandiol (C 8 H 18 O 2 ), leaving the fragment ion at m/z 337 for which we propose the structure of 6′,7′-dehydrobergamottin.…”

Studies on Coumarins of a Chinese Drug „Qian-Hu”

“…According to A. G. GONZALEZ et al [3], the 2'-gem-dimethyl groups of dihydropyran gives rise to two separate singlets in 3', 4'-trans, and a broad singlet or two close singlets in 3', 4'-cis compounds (see Table I). The 'H NMR signals appearing at ö 1.52 and 1.56 (L 0.04) in compound (7) and at 1.36 and 1.48 (L5 0.12) in compound (8) indicate a cis configuration at C3-and C4-in the former and a trans configuration in the latter.…”

Acorenone in the essential oil of flowering aerial parts of Seseli tortuosum L.

“…1 There are no therapeutic uses reported in the literature for this plant, except for an uterus anticancer activity evidenced by Hartwell. 2 Previous works on this plant evidenced the presence of coumarins in roots 3 and aerial parts. 4,5 Robeva and Tchackalova, 6 studying the roots, stems, and leaves of various species of Seseli, including S. tortuosum, evidenced a positive correlation between the essential oil content and the number and dimensions of ducts. This is the first paper about the chemical composition of the essential oil of S. tortuosum.…”