Pyrene End‐Labeled Diblock Glycopolymers: Synthesis and Aggregation

Abstract

Summary: A pyrene end‐labeled amphiphilic block copolymer, poly(ε‐caprolactone)‐block‐poly[6‐O‐(4‐vinylbenzyl)‐D‐galactose] (Py‐PCL‐b‐PVBG), was synthesized by a four‐step method. The aggregation behavior of the diblock copolymer in solution was studied by monitoring the fluorescence of pyrene. TEM measurements revealed that the aggregates obtained by first dissolving the copolymer in N,N‐dimethylformamide (DMF), followed by the addition of water, were primarily spheres with the PCL blocks in the core. The PVBG corona was then crosslinked with glutaraldehyde. Final removal of the PCL core was accomplished by degradation under basic conditions, which resulted in the formation of hollow glycopolymer nanospheres.

Recent advances in the synthesis of well‐defined glycopolymers

“…Although atom transfer radical polymerization (ATRP) has been found to be a useful technique for the synthesis of glycopolymers, as with NMP, the majority of the syntheses have involved the use of protected glycomonomers 54–70. Narain and Armes successfully synthesized glycomonomers [Fig.…”

Intermolecular interaction and morphology investigation of drug loaded ABA-triblock copolymers with different hydrophilic/lipophilic ratios

“…15,16 For longer PBA chains (TC-12000), no overlapped melting endotherm was found. This might be due to a decrease in compatibility of the shorter PEG chain with dominant PBA blocks and sufficient phase separation.…”

Glyconanoparticles for Biomedical Applications

“…The galactose-pendent glycopolymer-coated micelles demonstrated strong targeting ability towards ASGP-R positive HepG2 liver cancer cells compared with ASGP-R negative HEK293 cells. Using a corona-cross-linking method, Li et al fabricated a hollow glycopolymer nanosphere by degrading the PCL core [56]. A biodegradable polylactide-b-poly(6-O-acryloyl--D-galactopyranose) block copolymer was synthesized by a RAFT process, self-assembling into the galactose-pendent glycopolymercoated micelles with a polylactide core [57].…”