Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer

Abstract

: The incidence of cancer is increasing worldwide, affecting a vast majority of the human population. As new different anticancer agents are being developed now, the requirement is to deal somehow with them and evaluate their safety. Among them, pyridine based drugs are contributing a lot, as it is one of the imperative pharmacophores occurring synthetically as well as naturally in heterocyclic compounds, and having a wide range of therapeutic applications in the area of drug discovery, thereby offering many chances for further improvement in antitumor agents via acting onto numerous receptors of extreme prominence. Many pyridine derivatives have been reported to inhibit enzymes, receptors and many other targets for controlling and curing the global health issue of cancer. Nowadays, in combination with other moieties, researchers are focusing on the development of pyridine-based new derivatives for cancer treatment. Therefore, this review sheds light on the recent therapeutic expansions of pyridine together with its molecular docking, structure-activity-relationship, availability in the market, and a summary of recently patented and published research works that shall jointly help the scientists to produce effective drugs with the desired pharmacological activity.

Computational modeling and synthesis of Pyridine variants of Benzoyl-Phenoxy-Acetamide with high glioblastoma cytotoxicity and brain tumor penetration

“…In search for more effective benzoyl-phenoxy-acetamide (BPA) derivatives, we have decided to explore pyridine variants (Figure 2). This is because the pyridine moieties are part of a diverse group of compounds with broad pharmacological applications 33,34 . In addition, it is well documented that pyridine based compounds have a high probability to penetrate the CNS 35 .…”

Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays

“…Therefore, researchers are currently focusing on the development of pyridine-based novel derivatives for cancer treatment. [4][5][6] Literature survey showed that different fused rings bearing pyridine moiety exhibited anticancer activity such as pyrano [3,2-c] pyridine, pyrido [4,3-d]-pyrimidine and pyrazolo [4,3-c] pyridine derivatives 13 (Fig. 1).…”

Design, Synthesis, Characterization, and Anti-Cancer Activity Evaluation of Novel Thiosemicarbazide Analogs

“…It is the cause of about 30 percent of immediate deaths in adults aged 30 to 69 years due to non-communicable diseases. [1][2] Skin tumor is the most frequent type of malignancy with a total of 106,110 new melanomas diagnosed this year (about 62,260 in men and 43,850 in women), and melanoma is estimated to kill about 7,180 people. It occurs globally in all races, though the risk is significantly higher in Caucasians due to the photoprotective effect of epidermal melanin.…”