Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia

Yang, Wei; Liu, Shuai; Li, Yunlei; Wang, Yujie; Deng, Yao; Sun, Weimin; Huang, Hualan; Xie, Junmou; He, Anbang; Chen, Honglv; Tao, Ailin; Yan, Jie

doi:10.1016/j.canlet.2020.08.018

Cited by 36 publications

(21 citation statements)

References 32 publications

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“…This effect could subsequently promote a wider inflammatory response for the treatment of acute myeloid leukemia (AML). 63 …”

Section: The Role Of Pyroptosis In the Association Between Cancer And The Immune Systemmentioning

confidence: 99%

“…Moreover, the results of Yang et al demonstrated that pyridoxine (vitamin B6) could selectively induce monocyte macrophages to undergo GSDME‐mediated pyroptosis. This effect could subsequently promote a wider inflammatory response for the treatment of acute myeloid leukemia (AML) 63 …”

Section: The Role Of Pyroptosis In the Association Between Cancer And The Immune Systemmentioning

confidence: 99%

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Pyroptosis, a new bridge to tumor immunity

et al. 2021

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Environmental factors and genetic mutation have caused cancer incidence and mortality to rapidly increase. Cancer has become one of the crucial causes of death worldwide, and is becoming a major public health problem. 1 The traditional core types of cancer treatment are surgery, chemo-therapy, and radiation therapy, which can reduce tumor cell proliferation by inducing cancer cell death. 2 However, accumulating evidence has shown that tumors often relapse and it has been suggested that successful oncotherapy requires prolonged antineoplastic immunity. 3 The field of cancer immunotherapy (CIT) has emerged in recent years and aims to stimulate the body's immune system to create a robust immune response that can kill cancer cells. 4 This type of treatment can induce immunogenic cell death in different ways and achieve long-term anticancer immunity. 5 Although the application of CIT has been considered for a broad range of tumors, only a minority of patients achieve a satisfactory treatment effect due to immune escape. These results indicate that the immune system is intricate and still not well managed. 6 Thus, it is necessary to explore the mechanisms involved in CIT to develop more efficient methods of treatment for better cancer prevention and treatment.

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“…This effect could subsequently promote a wider inflammatory response for the treatment of acute myeloid leukemia (AML). 63 …”

Section: The Role Of Pyroptosis In the Association Between Cancer And The Immune Systemmentioning

confidence: 99%

Section: The Role Of Pyroptosis In the Association Between Cancer And The Immune Systemmentioning

confidence: 99%

Pyroptosis, a new bridge to tumor immunity

et al. 2021

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“…Recently, it has been shown that pyridoxine, an essential nutrient for the normal functioning of many biological systems, not only functions as vitamin B6 but also induces apoptosis of U937 cells or selectively activates apoptosis of THP‐1 cells through caspase‐8/3 and GSDME‐dependent pyroptosis. Yang et al 65 found that treatment with pyridoxine in combination with a caspase inhibitor to inhibit caspase‐8 induced a switch in monocyte death from apoptosis or pyroptosis to necroptosis. Consequently, necroptosis caused severe damage to membrane permeability, resulting in a high sensitivity of monocytes to drugs and the release of many inflammatory factors involved in the antitumor immune response.…”

Section: Impact Of Caspase‐8 In Cancer “Panoptosis”mentioning

confidence: 99%

Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer

Jiang

et al. 2021

Intl Journal of Cancer

116

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Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells. With the continuous exploration of the types of programmed cell death, an increasing number of studies have confirmed that caspase‐8 plays an important role in cancer. Recently, scholars have proposed the term “PANoptosis,” which mainly includes three programmed cell death modes, namely pyroptosis, apoptosis and necroptosis. In addition to mediating endogenous apoptotic pathways, caspase‐8 can also participate in the cleavage of gasdermin (GSDM) family proteins to induce pyroptosis. Furthermore, the expression of enzymatically inactive caspase‐8 (C362S) can cause embryonic lethality and inflammatory tissue destruction in mice by inducing necroptosis and pyroptosis. Therefore, the activation and deletion of caspase‐8 enzyme activity, as well as the knockout of the coding gene, are closely related to “PANoptosis.” In addition, caspase‐8 can also improve the tumor microenvironment and enhance tumor antiimmunity. Studies have shown that caspase‐8 is also associated with tumor growth and invasion, angiogenesis and metastasis, therapeutic resistance and poor clinical outcomes. Therefore, it is very important to measure the cancer‐promoting and anticancer effects of caspase‐8 and find a balance, and to study its role in the effect of “PANoptosis” in depth. This article reviews the role of caspase‐8 in “PANoptosis” in cancer to provide new strategies and targets for cancer.

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“…In addition, TEM indicates the location of various cellular structures with nanometer range resolution 64 , 65 . The entire cell death process can also be precisely observed and significantly distinguished from other cell death processes using automated live cell imagers 66 . For example, RAW-asc cells undergo pyroptosis after LPS + nigericin treatment 21 .…”

Section: Methods For Monitoring Pyroptosismentioning

confidence: 99%

Methods for monitoring cancer cell pyroptosis

Wang¹,

Liu²,

Lu³

et al. 2021

Cancer Biol Med

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Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response. The relationship between pyroptosis and cancer has become a popular topic in immunological research. Multiple strategies for inducing pyroptosis in cancer cells have been developed for cancer therapy, including chemotherapy, small molecule drugs, and nanomedicines. In this review, we systematically discuss recent advances in research on the mechanisms of pyroptosis, and compare pyroptosis with apoptosis and necroptosis from several aspects. The development of various experimental systems has accompanied rapid progress in this field, but little consensus on monitoring pyroptosis is currently available. We focus on techniques commonly used to monitor pyroptosis, and describe future techniques that may be used to increase our knowledge in this field. Overall, the advancement of pyroptosis detection methods will help researchers to better investigate the relationships between pyroptosis and various cancers, and should provide insights into the use of these promising tools for cancer treatments.

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Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia

Cited by 36 publications

References 32 publications

Pyroptosis, a new bridge to tumor immunity

Pyroptosis, a new bridge to tumor immunity

Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer

Methods for monitoring cancer cell pyroptosis

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