Pyrostegia venusta attenuate the sickness behavior induced by lipopolysaccharide in mice

Veloso, Clarice C.; Bitencourt, Andressa D.; Cabral, Layla D.M.; Franqui, Lidiane S.; Dias, Danielle Ferreira; Santos, Marcelo H. dos; Soncini, Roseli; Giusti‐Paiva, Alexandre

doi:10.1016/j.jep.2010.07.053

Cited by 34 publications

(31 citation statements)

References 17 publications

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“…Considering the inhibitory property of PvHE on the first phase of formalin, is traditional Brazilian medicine for the treatment of various inflammatory diseases. Our previous study demonstrated that the PvHE attenuated the sickness behavior in mice, supporting the popular use of flowers of Pyrostegia venusta as treatment for the general symptoms of flu and cold (Veloso et al, 2010). However, its pharmacological actions have not been completely investigated to date.…”

Section: Discussionmentioning

confidence: 86%

“…The content of total flavonoids was 543 mg quercetin equivalent/g extract. Our previous reports showed that a principal constituent was identified as the flavonoid acacetin-7-O-glycopyranoside by HPLC/ DAD analysis (Veloso et al, 2010). Figure 1 shows that the PvHE significantly inhibited (F 4,35 =6.12; p=0.0009) the carrageenaninduced mice paw edema at doses of 30-300 mg/kg at 3 h post carrageenan, with inhibitions of 56.5%, 74.78% and 89.13%, for 30, 100 and 300 mg/kg, respectively.…”

Section: Total Phenols and Flavonoids Contentsmentioning

confidence: 99%

“…They are administered orally as a general tonic for the treatment of diarrhea, vitiligo, cough and common infections and inflammatory diseases of the respiratory system, such as bronchitis, flu and the common cold (Ferreira et al, 2000;Scalon et al, 2008;Cardozo et al, 2009). Previous studies demonstrated that the hydroethanolic extract of flowers of P. venusta attenuated the sickness behavior induced by lipopolysaccharide (LPS) in the forced swim and open field test, suggesting that the extract inhibits immune and inflammatory responses, including cytokine and prostaglandin production, supporting the popular use of P. venusta as a general tonic as well as a treatment for the general symptoms of flu and cold (Veloso et al, 2010).…”

Section: Introductionmentioning

confidence: 96%

“…The literature records the phytochemical study of the fl owers of P. venusta, from which the compounds β-sitosterol, n-hentriacontane, acacetin-7-O-β-glucopyranoside and meso-inositol have been isolated (Dubey & Misra, 1976;Veloso et al, 2010). Other studies have indicated the presence of carotenoids in the fl owers (Harborne, 1967) and rutin in the leaves (Blatt et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Veloso¹,

Cabral²,

Bitencourt³

et al. 2012

Rev. bras. farmacogn.

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Pyrostegia venusta (Ker Gawl.) Miers, Bignoniaceae, is native to the Brazilian Cerrado and popularly known as "cipó-de-são-joão". In Brazilian folk medicine, the flowers of P. venusta are used as a general tonic and a treatment for diarrhea, vitiligo, cough, and common infections and inflammatory diseases of the respiratory system. Nevertheless, there are still no studies on its possible anti-inflammatory and antinociceptive effects. The P. venusta hydroethanolic extract (PvHE) was used to evaluate the anti-inflammatory and analgesic effects in carrageenan-induced paw edema, peritonitis induced by lipopolysaccharide, acetic acid-induced writhing, and formalin-induced paw-licking tests in Swiss male mice. PvHE at doses of 30-300 mg/kg p.o. demonstrated anti-inflammatory effect. PvHE reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. The extracts showed antinociceptive activity in acetic acid-induced writhing and formalin tests. Our results showed that the PvHE demonstrated anti-inflammatory and antinociceptive action in mice. All the anti-inflammatory actions obtained are also suggested to due the presence of acacetin-7-O-β-glucopyranoside.

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Section: Discussionmentioning

confidence: 86%

Section: Total Phenols and Flavonoids Contentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Veloso¹,

Cabral²,

Bitencourt³

et al. 2012

Rev. bras. farmacogn.

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“…Além do uso ornamental, as flores e folhas dessa espécie também são utilizadas na medicina popular, como no tratamento de gripe e resfriado (MARONI et al 2006;VELOSO et al 2010).…”

Section: Introductionunclassified

Utilização de diferentes substratos na propagação de Pyrostegia venusta através de estacas

Crispim

Rêgo

et al. 2015

Revista Verde

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Este trabalho teve por objetivo avaliar o desenvolvimento de clones de Pyrostegia venusta em diferentes tipos de substratos. O experimento foi conduzido em delineamento inteiramente casualizado, com 06 tratamentos e 10 repetições, cada repetição foi constituída por um tubete de polietileno com capacidade de 103cm3. Os tratamentos testados foram: (T1) 100% de areia lavada; (T2) 50% areia lavada + 50% substrato comercial Plantmax®; (T3) 100% de substrato comercial Plantmax®; (T4) 50% areia lavada + 50% de esterco bovino; (T5) 1/3 areia lavada + 1/3 esterco bovino +1/3 de Plantmax® e (T6) 50% esterco bovino + 50% de Areia lavada. Após 30 dias foram avaliados o número de estacas sobreviventes, comprimento do broto (cm), número de folhas, comprimento da folha (cm), número de raízes e comprimento da raiz principal (cm). Os dados foram submetidos a análise de variância e as médias comparadas pelo teste de Tukey a 5% de probabilidade. Por meio da análise de variância (p<0,01), detectou-se significância estatística, para as variáveis, sobrevivência das estacas e número de brotos por estaca de P. venusta, quando cultivadas em substrato composto por 50% areia lavada + 50% substrato comercial Plantmax®. Essa mistura apresenta a vantagem de ser mais econômica quando comparado ao substrato comercial Plantmax®, sendo portanto, recomendada na produção de mudas de cipó-de-São João.Utilization of different substrates in the propagation of Pyrostegia venusta by cuttingsAbstract: The experiment was carried out in a completely randomized design with 06 treatments and 10 replicates, each replicate consisted of polyethylene plastic tube the size of 103cm3. The treatments were: (T1) 100% washed sand; (T2) 50% washed sand + 50% commercial substrate Plantmax®; (T3) 100% substrate commercial Plantmax®; (T4) 50 % washed sand + 50% cattle manure; (T5) 1/3 washed sand + 1/3 manure +1/3 Plantmax® and Plantmax (T6) 50 % cattle manure + 50% washed sand. After 30 days, were evaluated number of cutting survival, bud length in cm, number of leaves, leaf length in cm, number of roots and length of the main root. Data were submitted to analysis of variance and means were compared by Tukey test at 5% probability. By analysis of variance (p< 0.01), there was significant differences for the variables, czutting survival and number of shoots per cutting when cultured on substrate composed of 50% washed sand + 50% commercial substrate Plantmax®. Furthermore, this mixture has the advantage to be cheaper as compared to substrate Plantmax®, so we recommend the seedlings of Saint John’s vine.

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Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Shaikh

Dhadde²,

Durg

et al. 2016

Phytotherapy Research

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Sickness behaviour is a coordinated set of adaptive behavioural changes that develop in ill individuals during the course of an infection. It is relevant to understanding depression and some aspects of the suffering that in cancer. Embelin has been reported to possess antiinflammatory, neuroprotective and anxiolytic assets and has been shown to inhibit nuclear factor κB pathway and cytokine production. The present study was undertaken to investigate the effect of embelin isolated from Embelia ribes Burm in lipopolysaccharide (LPS)-induced sickness behaviour in mice. Adult male Swiss albino mice were pre-treated with embelin (10 and 20 mg/kg, p.o.) or dexamethasone (1 mg/kg, i.p.) for 3 days and then challenged with LPS (400 µg/kg, i.p.). At different time intervals of post-LPS challenge, sickness behaviour was evaluated in the animals by battery of behavioural tests (plus maze, open field, light-dark box, forced swim, social behaviour assessment, sucrose preference and food and water intake). Levels of oxidative stress makers (reduced glutathione and lipid peroxidation) in mice brain were also analysed. LPS induced behavioural alterations, anhedonia and anorexia, in mice. Pre-treatment with embelin attenuated behavioural changes induced by LPS. In addition, embelin prevented anhedonia, anorexia and ameliorated brain oxidative stress markers. The experimental outcomes of the present study demonstrated protective effect of embelin in LPS-induced sickness behaviour in mice. Copyright © 2016 John Wiley & Sons, Ltd.

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Pyrostegia venusta attenuate the sickness behavior induced by lipopolysaccharide in mice

Cited by 34 publications

References 17 publications

Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Utilização de diferentes substratos na propagação de Pyrostegia venusta através de estacas

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

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