Pyrrolomycins C,D and E,new members of pyrrolomycins.

Ezaki, Norio; Koyama, Masato; Shomura, Takashi; Tsuruoka, Takashi; Inouye, Shigeharu

doi:10.7164/antibiotics.36.1263

Cited by 59 publications

(41 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6) are produced by the actinomycete Actinosporangium vitaminophilum. These compounds are active against not only fungi but also some Gram-negative and Gram-positive bacteria (45,46).…”

Section: Naturally Occurring Nitroaromatic Compoundsmentioning

confidence: 99%

Nitroaromatic Compounds, from Synthesis to Biodegradation

Parales

2010

Microbiol Mol Biol Rev

772

470

View full text Add to dashboard Cite

SUMMARY Nitroaromatic compounds are relatively rare in nature and have been introduced into the environment mainly by human activities. This important class of industrial chemicals is widely used in the synthesis of many diverse products, including dyes, polymers, pesticides, and explosives. Unfortunately, their extensive use has led to environmental contamination of soil and groundwater. The nitro group, which provides chemical and functional diversity in these molecules, also contributes to the recalcitrance of these compounds to biodegradation. The electron-withdrawing nature of the nitro group, in concert with the stability of the benzene ring, makes nitroaromatic compounds resistant to oxidative degradation. Recalcitrance is further compounded by their acute toxicity, mutagenicity, and easy reduction into carcinogenic aromatic amines. Nitroaromatic compounds are hazardous to human health and are registered on the U.S. Environmental Protection Agency's list of priority pollutants for environmental remediation. Although the majority of these compounds are synthetic in nature, microorganisms in contaminated environments have rapidly adapted to their presence by evolving new biodegradation pathways that take advantage of them as sources of carbon, nitrogen, and energy. This review provides an overview of the synthesis of both man-made and biogenic nitroaromatic compounds, the bacteria that have been identified to grow on and completely mineralize nitroaromatic compounds, and the pathways that are present in these strains. The possible evolutionary origins of the newly evolved pathways are also discussed.

show abstract

“…6) are produced by the actinomycete Actinosporangium vitaminophilum. These compounds are active against not only fungi but also some Gram-negative and Gram-positive bacteria (45,46).…”

Section: Naturally Occurring Nitroaromatic Compoundsmentioning

confidence: 99%

Nitroaromatic Compounds, from Synthesis to Biodegradation

Parales

2010

Microbiol Mol Biol Rev

772

470

View full text Add to dashboard Cite

show abstract

“…The other natural pyrrolomycins were less toxic: pyrrolomycin A and B showed LD50 values of 21.2 and about 100 mg/kg, respectively, when administered i.p. to JCL-ICR mice [37]; pyrrolomycins C and D showed LD50 values of 50 mg/kg and 20 mg/kg, respectively [35].…”

Section: Antibacterial Activity Of Natural Pyrrolomycinsmentioning

confidence: 98%

“…Pyrrolomycins (PM) are polyhalogenated metabolites known for their potent antimicrobial properties [31], isolated from the fermentation broth of Actinosporangium and Streptomyces species [32][33][34][35][36][37]. The antibiotics of this family include pyrrolomycins A, B, C, D, E, G, H, I, J and dioxapyrrolomycin ( Figure 3).…”

Section: Natural Pyrrolomycinsmentioning

confidence: 99%

“…Pyrrolomycins (PM) are polyhalogenated metabolites known for their potent antimicrobial properties [31], isolated from the fermentation broth of Actinosporangium and Streptomyces species [32][33][34][35][36][37] Important structural features of the pyrrolomycins are: (i) their high halogenation degree, which is usually represented by chlorine substituents; and (ii) in some cases, the presence of a nitro group at the position 3 of the pyrrole ring. The antibacterial activity of these derivatives may be closely related to their halogen content, because it increases as the degree of halogenation [38,39].…”

Section: Natural Pyrrolomycinsmentioning

confidence: 99%

See 1 more Smart Citation

Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

et al. 2015

View full text Add to dashboard Cite

Abstract:The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.

show abstract

“…For example, pyrrolomycins, a family of halogenated pyrrole antibiotics, produced by Actinosporangium vitaminophilum SF-2080, was isolated in 1983 [11]. A member of above mentioned family, pyrrolomycin D, has a broad spectrum including Gram-positive, Gram-negative bacteria and fungi.…”

Section: Editorialmentioning

confidence: 99%

The Re-Discovering of Old Molecules to face the Antibiotic Crisis

Schillaci¹

2015

J Microb Biochem Technol

View full text Add to dashboard Cite

Pyrrolomycins C,D and E,new members of pyrrolomycins.

Cited by 59 publications

References 4 publications

Nitroaromatic Compounds, from Synthesis to Biodegradation

Nitroaromatic Compounds, from Synthesis to Biodegradation

Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

The Re-Discovering of Old Molecules to face the Antibiotic Crisis

Contact Info

Product

Resources

About