The study's objective was to report the nurses' self-evaluation of health and quality of life, associated with the socioeconomic characterization. Transversal study, with a sample of 190 nurses, in a state's reference general hospital. For procedures of descriptive analysis and inferences, the Statistical Package for Social Sciences 13.0 used. The comparison of averages was made, using statistical tests: Mann-Whitney, Friedman, t of Student and ANOVA. For the accomplishment of correlation analysis, the Spearman's correlation coefficient was used. The study strictly followed the regulation of national and international research. One observes a population mainly composed of women, with average age of 36.04 years old, working in nursing for 9.05 years, with family income of R$ 8,410.11 and weekly workload of 47.16 hours. The satisfaction with health had a score of 57.50 and the quality of life's self-evaluation, 61.32. Through the findings, it was possible to demonstrate the existing correlation between the workload's increase and a worst self-evaluation regarding the quality of life.