Qualitative and quantitative analysis of thermosensitive liposomes loaded with doxorubicin

Tazina, E. V.; Ignatieva, E. V.; Полозкова, А. П.; Оборотова, Н. А.

doi:10.1007/s11094-012-0733-0

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The spectra of interactions of DOX with other amino acids pointed at no interactions at the constant concentration of doxorubicin when compared different concentrations of AA ( Figures 2 and 3 ). Doxorubicin exhibited the maximum at λ = 480 nm, which corresponds to findings published in several studies [ 33 – 35 ]. Lysine ( Figure 2A ), whose amino group is highly reactive and often participates in enzymatic reactions [ 29 ], β-alanine ( Figure 2E ), serine ( Figure 3G ), valine ( Figure 3I ) and arginine ( Figure 3M ) showed significantly stronger interaction with DOX with the increasing concentration (in a concentration dependent manner; highest effects observed at the concentration of 1000 μg mL −1 ) and thus indicated the highest binding affinity for the formation of complex with DOX.…”

Section: Resultssupporting

confidence: 88%

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Heger

Cernei

Kudr

et al. 2013

IJMS

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Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.

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Section: Resultssupporting

confidence: 88%

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Heger

Cernei

Kudr

et al. 2013

IJMS

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“…Saetern et al investigated the stability of camptothecin containing liposomes by an HPTLC method [27]. In another study, the fabrication of thermosensitive liposomes used in combination with local hyperthermia (40 -43°C) was evaluated in order to increase the selectivity of doxorubicin action and a TLC method was developed for the analysis of thermosensitive liposomes loaded with doxorubicin [28]. The combination of daunorubicin and 6-mercaptopurine in liposomes was also investigated for better chemotherapy and liposome stability experiments were evaluated by using TLC method [29].…”

Section: Analysis Of Anticancer Drugs Using Tlc Methods In Bulk Drug Amentioning

confidence: 99%

Analysis of anticancer drugs using thin layer chromatography- A review

Uğur¹,

Uğur²

2018

jrp

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ABSTRACT:Cancer is a fatal disease and cancer incidence is increasing from day to day. Thus, anticancer drugs are widely used and their analysis requires simple and effective analytical procedures. Thin layer chromatography (TLC) is a promising technique for drug analysis as a simple and versatile technique with low cost of analysis, minimal sample clean-up and high sample loading capacity. An extensive literature survey has been done and TLC techniques used for the analysis of anticancer agents in different matrices have been presented.

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“…Блохина РАМН разработана лиофилизированная термочувствительная липосомальная лекарственная форма доксорубицина с размером частиц 170 ± 20 нм и эффективностью инкапсулирования препарата в везикулы 87-94% [62,63]. В доклинических испытаниях, проведенных на меланоме В16 и солидной карциноме Эрлиха линии ELD, показано, что термолипосомальный доксорубицин в комбинации с локальной гипертермией (43 °C) обладает большей избирательностью действия по сравнению со свободным доксорубицином [62,64,65].…”

Section: липосомы чувствительные к физическим и химическим стимуламunclassified

Nanostructured Liposomal Systems as Transport Agents for Anticancer Drugs

Барышников

2012

Annals RAMS

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Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.

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Qualitative and quantitative analysis of thermosensitive liposomes loaded with doxorubicin

Cited by 3 publications

References 9 publications

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Analysis of anticancer drugs using thin layer chromatography- A review

Nanostructured Liposomal Systems as Transport Agents for Anticancer Drugs

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