The results of assessing the effect of biological preparations and a seed disinfectant on the technological qualities of grain of soft spring wheat Novosibirskaya 31 are presented. The effectiveness of the use of biological plant protection products was studied in the field experiment, laid down in 2020 in the forest-steppe conditions of the Ob region. Pre-sowing seed treatment included the following options: control (without treatment); Trichodermin, P (Trichoderma viride, titer more than 6 billion spores/g), consumption rate – 15 kg/t seed; Sporobacterin, SP (Bacillus subtilis + Trichoderma viride, strain 4097), consumption rate – 0.5 kg/ton of seeds; Scarlet, ME, chemical standard (imazalil (100 g/l) + tebuconazole (60 g/l), consumption rate – 0.3 l/t of seeds. The use of the preparations contributed to an increase in yield by 0.40 and 0.52 t/ha when using Trichodermin and Sporobacterin, respectively, and by 0.08 t/ha when using fungicide Scarlet. In this case, the mass of 1000 grains increased by 0.84, 0.80 and 0.96 g, respectively, relative to the control. The preparations Trichodermin and Sporobacterin had a significant effect on the growth of grain in length and width relative to the control – by 5.4-6.9 and 9.6%, Scarlet – by 10.6 and 13.9%, respectively. Pre-sowing seed treatment contributed to the growth of such indicators of the caryopsis as volume (by 19.6–29.3%), surface area (by 12.1–19.2%), and sphericity (by 6.3–7.8%). To a greater extent, they increased with the use of fungicide Scarlet. Getting larger grain led to an increase in the endosperm content by 0.76–1.14%. A close correlation has been shown between the indicators of the mass of 1000 grains and the linear grain sizes (r = 0.92–0.98), as well as with the grain volume, sphericity and endosperm content (r = 0.98–0.99). Pre-sowing treatment of spring wheat seeds provides grain with improved technological properties.