Quality assessment of South African herbal medicines by means of HPLC fingerprinting

Springfield, E.P.; Eagles, P.; Scott, Gillian

doi:10.1016/j.jep.2005.03.012

Cited by 84 publications

(54 citation statements)

References 24 publications

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“…É reconhecido que dados de eficácia e segurança de várias plantas medicinais ainda não são suficientes para dar suporte ao seu uso, por vezes devido à falta de metodologias adequadas de avaliação dessas plantas. E, em se tratando da composição, muitas vezes não se tem estabelecido o princípio ativo ou tóxico, sua concentração e seu conhecimento farmacológico e toxicológico (Barata, 2005;Springfield et al, 2005).…”

Section: Técnicas De Controle De Qualidadeunclassified

Section: Introductionunclassified

“…Entretanto, até a metade do século XX, o uso de medicamentos de origem sintética tornou-se mais amplo que o uso de plantas medicinais, principalmente na sociedade ocidental, com destaque para os países desenvolvidos visto que os considerados países em desenvolvimento permaneceram fazendo uso das propriedades curativas das plantas, certamente devido às difíceis condições econômicas de aquisição dos medicamentos sintéticos (Korolkovas, 1996;Farnsworth, 1997;Rates, 2001;Springfield et al, 2005;Foglio et al, 2006;Gupta et al, 2008). A Organização Mundial da Saúde (OMS) estimou que 80% da população dependam da medicina tradicional (Springfield et al, 2005). A cultura do uso de plantas e de outras fontes naturais com propriedades terapêuticas vem sendo valorizada pela sociedade do mundo inteiro e retornou ao status de uma fonte de produtos medicinais devido à busca por hábitos mais saudáveis de vida e pelo difícil tratamento de certas doenças e resistência microbiana (De Smet, 2004;Giveon et al, 2004;Rocha et al, 2004;Bugno et al, 2005).…”

Section: Introductionunclassified

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O Brasil no contexto de controle de qualidade de plantas medicinais

Souza-Moreira¹,

Salgado²,

Pietro³

2010

Rev. bras. farmacogn.

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RESUMO:Atualmente, as plantas medicinais movem altos valores financeiros em todo o mundo e representam o tipo de tratamento mais acessível para cerca de 80% da população, principalmente entre os países em desenvolvimento. Entretanto, existe ainda uma falta de conhecimento sobre propriedades químicas, farmacológicas e toxicológicas a fim de assegurar a eficácia e segurança das plantas medicinais. Os critérios de eficácia e segurança de plantas medicinais estão relacionados a qualidade, isto é, as plantas necessitam ser corretamente identificadas, cultivadas e coletadas, devem estar livres de material estranho, partes de outras plantas e contaminações inorgânicas e/ ou microbianas. O objetivo deste estudo foi o de elucidar os diferentes processos e padronizações sobre o controle de drogas vegetais, principalmente no Brasil.Unitermos: Plantas medicinais, fitoquímica, controle de qualidade.ABSTRACT: "Brazil in the context of plants and derivates quality control". Nowadays medicinal plants move high financial values at the world and represent a type of treatment more accessible for about 80% of people, mainly among developing countries. However, there is a lack of knowledge about chemical, pharmacological and toxicological properties towards ensure their efficacy and safety. Efficacy and safety criteria of medicinal plants are related to quality, that is, the plants need to be correctly identified, cultivated and harvested, they must be free of strange material, part of other plants and inorganic and/or microorganisms contamination. The aim of this study was to elucidate different process and standardizations about quality control of vegetal drugs mainly in Brazil. ISSN 0102-695X Keywords INTRODUÇÃOPor longos períodos na história, o uso de plantas medicinais foi presente não só devido ao seu caráter alimentar, mas também às suas propriedades de cura, sejam elas reais ou ritualísticas. Entretanto, até a metade do século XX, o uso de medicamentos de origem sintética tornou-se mais amplo que o uso de plantas medicinais, principalmente na sociedade ocidental, com destaque para os países desenvolvidos visto que os considerados países em desenvolvimento permaneceram fazendo uso das propriedades curativas das plantas, certamente devido às difíceis condições econômicas de aquisição dos medicamentos sintéticos

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Section: Técnicas De Controle De Qualidadeunclassified

Section: Introductionunclassified

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O Brasil no contexto de controle de qualidade de plantas medicinais

Souza-Moreira¹,

Salgado²,

Pietro³

2010

Rev. bras. farmacogn.

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“…Thin layer chromatography studies indicate that benzylamine and momordicine are probably the active components in M. oleifera leaf powder and M. charantia lyophilized fruit powder, respectively. HPLC fingerprinting is the best way for chemical characterization 33 . In the present study, similar retention times were recorded for column purified M. oleifera leaf extract (2.59 min) and benzylamine (2.58 min).…”

Section: Discussionmentioning

confidence: 99%

CHARACTERIZATION OF MOLLUSCICIDAL COMPONENT OF Moringa oleifera LEAF AND Momordica charantia FRUITS AND THEIR MODES OF ACTION IN SNAIL Lymnaea acuminata

Upadhyay

Singh

2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe molluscicidal activity of the leaf powder of Moringa oleifera and lyophilized fruit powder of Momordica charantia against the snail Lymnaea acuminata was time and concentration dependent. M. oleifera leaf powder (96 h LC 50 : 197.59 ppm) was more toxic than M. charantia lyophilized fruit powder (96 h LC 50 : 318.29 ppm). The ethanolic extracts of M. oleifera leaf powder and Momordica charantia lyophilized fruit powder were more toxic than other organic solvent extracts. The 96 h LC 50 of the column purified fraction of M. oleifera leaf powder was 22.52 ppm, while that of M. charantia lyophilized fruit powder was 6.21 ppm. Column, thin layer and high performance liquid chromatography analysis show that the active molluscicidal components in M. oleifera leaf powder and lyophilized fruit of M. charantia are benzylamine (96 h LC 50 : 2.3 ppm) and momordicine (96 h LC 50 : 1.2 ppm), respectively. Benzylamine and momordicine significantly inhibited, in vivo and in vitro, the acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissues of L. acuminata. Inhibition of AChE, ACP and ALP activity in the nervous tissues of L. acuminata by benzylamine and momordicine may be responsible for the molluscicidal activity of M. oleifera and M. charantia fruits, respectively.

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“…It was observed that, in the last years, it has been an increasing interest by the large companies and some governments in such products, stimulating their standardization and the development of reliable quality control analytical methodologies to support their safety and efficacy (WHO, 1998;Calixto, 2000;Springfield et al, 2005;Ferrante et al, 2007;Migliato et al, 2007;Chaves & Costa, 2008;Engel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines

Bueno¹,

Bastos²

2009

Rev. bras. farmacogn.

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A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines ABSTRACT: This work describes a full validation of a capillary gas chromatography analytical methodology using internal standardization for the quantification of coumarin (1,2-benzopyrone) in guaco (Mikania glomerata Spreng -Asteraceae) products: syrup, plant and its extract, including the stability study of the phytomedicine. For the analysis, it was used an HP-5 capillary column (30 m x 0.32 mm x 0.25 µm), hydrogen at a flow rate of 1.8 mL/min and the increasing temperature gradient was: 100 °C to 250 °C, 15 ºC/min. The temperature of injector (split 1:20) and detector were kept at 250 °C and 270 °C, respectively. The retention times of the standards for the above conditions were 2.86 minutes for 1, 2, 3, 4-tetramethylbenzene, 4.45 min for piperonal (internal standards), and 5.36 minutes for coumarin. After extraction procedure, the recovery of coumarin determined for plant raw material was 101.6 %, while for syrup it was 100.8 %. Detection and quantification limits were 0.5 µg/mL and 1.5 µg/mL, respectively. Precision was determined for all samples and the results were lower than 2.5 %. The total amount of coumarin in plant raw material, its extract and syrup were 0.38 % w/w, 1.33 mg/mL and 0.143 mg/mL, respectively.

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Quality assessment of South African herbal medicines by means of HPLC fingerprinting

Cited by 84 publications

References 24 publications

O Brasil no contexto de controle de qualidade de plantas medicinais

O Brasil no contexto de controle de qualidade de plantas medicinais

CHARACTERIZATION OF MOLLUSCICIDAL COMPONENT OF Moringa oleifera LEAF AND Momordica charantia FRUITS AND THEIR MODES OF ACTION IN SNAIL Lymnaea acuminata

A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines

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